北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 病理学系  > 期刊论文
学科主题: 基础医学
题名:
Cytokeratin-positive subserosal myofibroblasts in gastroduodenal ulcer; another type of myofibroblasts
作者: Guo, L; Kuroda, N; Nakayama, H; Miyazaki, E; Hayashi, Y; Toi, M; Hiroi, M; Enzan, H
关键词: myofibroblast ; subserosal cell ; cytokeratin ; peptic ulcer
刊名: HISTOLOGY AND HISTOPATHOLOGY
发表日期: 2006-07-01
卷: 21, 期:7, 页:697-704
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Pathology
研究领域[WOS]: Cell Biology ; Pathology
关键词[WOS]: PERITONEAL-DIALYSIS ; MESOTHELIAL CELLS ; SEROSAL TISSUE ; STROMAL CELLS ; CARCINOMA ; ACTIN
英文摘要:

To investigate the distribution and origin of alpha-smooth muscle actin (ASMA)-positive stromal cells in the perforation of human gastroduodenal ulcers. Perforative lesions of 24 surgically resected gastroduodenal ulcers were examined immunohistochemically for ASMA, HCD, CD34, CD31, CAM5.2 and HMW-CK, and double staining of ASMA and CAM5.2 was also performed. In addition, to determine the cell source of collagen, in situ hybridization of collagen 1 mRNA was performed. In the normal gastroduodenal wall, the reticular network of CD34-positive stromal cells was identified in the muscularis mucosa, submucosa, muscular propria, and subserosa. In the subepithelial area, many myofibroblasts were observed, whereas no CD34-positive stromal cells were seen. In areas neighboring ulcerative lesions, no CD34-positive stromal cells were observed, but a significant number of myofibroblasts were present there. In the deep layer of ulceration, numerous fusiform or stellate stromal cells strongly positive for ASMA and CAM5.2 were observed in the subserosal area around the perforation. In the same site, many cells co-expressing ASMA and CAM5.2 were identified by double staining. In contrast, in the surface layer of ulceration, stromal cells expressing only ASMA were observed. The cytokeratin-positive subserosal myofibroblastic cell in human gastroduodenal ulcer is a novel type of myofibroblast.

语种: 英语
WOS记录号: WOS:000237131300002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59512
Appears in Collections:基础医学院_病理学系_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100083, Peoples R China
2.Kochi Med Sch, Program Bioregulat & Genet, Dept Pathol, Kochi 783, Japan
3.Hiroshima Univ, Grad Sch Biomed Sci, Dept Mol Pathol, Hiroshima 730, Japan

Recommended Citation:
Guo, L,Kuroda, N,Nakayama, H,et al. Cytokeratin-positive subserosal myofibroblasts in gastroduodenal ulcer; another type of myofibroblasts[J]. HISTOLOGY AND HISTOPATHOLOGY,2006,21(7):697-704.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Guo, L]'s Articles
[Kuroda, N]'s Articles
[Nakayama, H]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Guo, L]‘s Articles
[Kuroda, N]‘s Articles
[Nakayama, H]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace