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学科主题基础医学
Cytokeratin-positive subserosal myofibroblasts in gastroduodenal ulcer; another type of myofibroblasts
Guo, L; Kuroda, N; Nakayama, H; Miyazaki, E; Hayashi, Y; Toi, M; Hiroi, M; Enzan, H
关键词myofibroblast subserosal cell cytokeratin peptic ulcer
刊名HISTOLOGY AND HISTOPATHOLOGY
2006-07-01
21期:7页:697-704
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Pathology
研究领域[WOS]Cell Biology ; Pathology
关键词[WOS]PERITONEAL-DIALYSIS ; MESOTHELIAL CELLS ; SEROSAL TISSUE ; STROMAL CELLS ; CARCINOMA ; ACTIN
英文摘要

To investigate the distribution and origin of alpha-smooth muscle actin (ASMA)-positive stromal cells in the perforation of human gastroduodenal ulcers. Perforative lesions of 24 surgically resected gastroduodenal ulcers were examined immunohistochemically for ASMA, HCD, CD34, CD31, CAM5.2 and HMW-CK, and double staining of ASMA and CAM5.2 was also performed. In addition, to determine the cell source of collagen, in situ hybridization of collagen 1 mRNA was performed. In the normal gastroduodenal wall, the reticular network of CD34-positive stromal cells was identified in the muscularis mucosa, submucosa, muscular propria, and subserosa. In the subepithelial area, many myofibroblasts were observed, whereas no CD34-positive stromal cells were seen. In areas neighboring ulcerative lesions, no CD34-positive stromal cells were observed, but a significant number of myofibroblasts were present there. In the deep layer of ulceration, numerous fusiform or stellate stromal cells strongly positive for ASMA and CAM5.2 were observed in the subserosal area around the perforation. In the same site, many cells co-expressing ASMA and CAM5.2 were identified by double staining. In contrast, in the surface layer of ulceration, stromal cells expressing only ASMA were observed. The cytokeratin-positive subserosal myofibroblastic cell in human gastroduodenal ulcer is a novel type of myofibroblast.

语种英语
WOS记录号WOS:000237131300002
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被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59512
专题北京大学基础医学院_病理学系
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100083, Peoples R China
2.Kochi Med Sch, Program Bioregulat & Genet, Dept Pathol, Kochi 783, Japan
3.Hiroshima Univ, Grad Sch Biomed Sci, Dept Mol Pathol, Hiroshima 730, Japan
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GB/T 7714
Guo, L,Kuroda, N,Nakayama, H,et al. Cytokeratin-positive subserosal myofibroblasts in gastroduodenal ulcer; another type of myofibroblasts[J]. HISTOLOGY AND HISTOPATHOLOGY,2006,21(7):697-704.
APA Guo, L.,Kuroda, N.,Nakayama, H.,Miyazaki, E.,Hayashi, Y.,...&Enzan, H.(2006).Cytokeratin-positive subserosal myofibroblasts in gastroduodenal ulcer; another type of myofibroblasts.HISTOLOGY AND HISTOPATHOLOGY,21(7),697-704.
MLA Guo, L,et al."Cytokeratin-positive subserosal myofibroblasts in gastroduodenal ulcer; another type of myofibroblasts".HISTOLOGY AND HISTOPATHOLOGY 21.7(2006):697-704.
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