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Let-7g is involved in doxorubicin induced myocardial injury
Fu, Jun; Peng, Cike; Wang, Wanyi; Jin, Haifeng; Tang, Qiuqiong; Wei, Xuetao
关键词Doxorubicin Let-7g miRNA Cardiac injury
刊名ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
2012-03-01
DOI10.1016/j.etap.2011.12.023
33期:2页:312-317
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Environmental Sciences ; Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]Environmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology
关键词[WOS]INDUCED CARDIOTOXICITY ; CARDIAC-HYPERTROPHY ; MICRORNAS ; INHIBITION ; HEART ; RATS
英文摘要

Objectives: To investigate whether let-7g (miRNA) was involved in doxorubicin-induced cardiotoxicity.

Methods: Rats were treated with doxorubicin at increasing doses (0 mg/kg, 6 mg/kg, 12 mg/kg, 18 mg/kg). Heart rate, pulse pressure and plasma cardiac troponin T concentrations were measured. Primary cultured myocardial cells were incubated with DOX at increasing concentrations (0 mu mol/1, 0.004 mu mol/1, 0.02 mu mol/1, 0.1 mu mol/1, 0.5 mu mol/1) for 24h. Cellular viability and the beat frequency were measured. For both rats and cultured cells, miRNA content was measured by real-time reverse-transcription PCR.

Results: All DOX-treated rats had a decrease in heart rate, an increase in pulse pressure compared with control group after injections (p < 0.05). Concentration of cTnT was increased significantly in 18 mg/kg group. Content of let-7g decreased significantly (p < 0.05) in 18 mg/kg group in vivo and all the doxorubicin treated group in vitro.

Conclusions: The down regulation of let-7g in the myocardial-injury model suggests that let-7g may play an important role in the development of cardiac disease. (C) 2012 Published by Elsevier B.V.

语种英语
WOS记录号WOS:000301475000024
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59514
专题北京大学公共卫生学院_毒理学系
北京大学公共卫生学院_公共卫生学院
作者单位Peking Univ, Dept Toxicol, Hlth Sci Ctr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Fu, Jun,Peng, Cike,Wang, Wanyi,et al. Let-7g is involved in doxorubicin induced myocardial injury[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2012,33(2):312-317.
APA Fu, Jun,Peng, Cike,Wang, Wanyi,Jin, Haifeng,Tang, Qiuqiong,&Wei, Xuetao.(2012).Let-7g is involved in doxorubicin induced myocardial injury.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,33(2),312-317.
MLA Fu, Jun,et al."Let-7g is involved in doxorubicin induced myocardial injury".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 33.2(2012):312-317.
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