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学科主题: 临床医学
题名:
Changes and significance of serum angiopoietin-2 levels in patients with coronary heart disease
作者: Wang, Xin1,2,3; Yong, Huijuan1,2; Mi, Lin1,2; Bai, Yun4; Guo, Lijun1,2; Gao, Wei1,2; Cui, Ming1,2; Zhang, Yongzhen1,2
关键词: Angiopoietin-2 ; coronary heart disease ; biomarker ; inflammation
刊名: BIOMARKERS
发表日期: 2012-12-01
DOI: 10.3109/1354750X.2012.727028
卷: 17, 期:8, 页:745-749
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Toxicology
研究领域[WOS]: Biotechnology & Applied Microbiology ; Toxicology
关键词[WOS]: TIE-2 LIGAND ANGIOPOIETIN-2 ; ENDOTHELIAL-CELLS ; EXPRESSION ; INFLAMMATION ; ANGIOGENESIS ; MORTALITY ; SEVERITY ; ISCHEMIA ; MARKERS ; SEPSIS
英文摘要:

Coronary heart disease (CHD) is characterized by inflammatory process and endothelial dysfunction. To investigate angiopoietin-2 (Ang-2) profiles, we evaluated serum Ang-2 levels in different types of CHD in 166 subjects. Ang-2 was measured by enzyme-linked immunosorbent assay. Serum Ang-2 levels were significantly elevated in patients with CHD and gradually increased with advance of CHD. Ang-2 was positively correlated with Gensini scores and hs-CRP. Ang-2 might have potential implication in detecting and monitoring the progression of CHD.

语种: 英语
所属项目编号: 81070260 ; 31070948 ; 7102099 ; 7122200
项目资助者: National Natural Sciences Foundation of China ; Beijing Natural Sciences Foundation
WOS记录号: WOS:000311681100008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59516
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Cardiol, Beijing 100191, Peoples R China
2.Minist Hlth, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, Beijing, Peoples R China
3.Capital Med Univ, Beijing Chao Yang Hosp, Ctr Heart, Beijing, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Cell Biol, Beijing 100191, Peoples R China

Recommended Citation:
Wang, Xin,Yong, Huijuan,Mi, Lin,et al. Changes and significance of serum angiopoietin-2 levels in patients with coronary heart disease[J]. BIOMARKERS,2012,17(8):745-749.
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