IR@PKUHSC  > 北京大学第三临床医学院  > 心血管内科
学科主题临床医学
Changes and significance of serum angiopoietin-2 levels in patients with coronary heart disease
Wang, Xin1,2,3; Yong, Huijuan1,2; Mi, Lin1,2; Bai, Yun4; Guo, Lijun1,2; Gao, Wei1,2; Cui, Ming1,2; Zhang, Yongzhen1,2
关键词Angiopoietin-2 coronary heart disease biomarker inflammation
刊名BIOMARKERS
2012-12-01
DOI10.3109/1354750X.2012.727028
17期:8页:745-749
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Toxicology
资助者National Natural Sciences Foundation of China ; Beijing Natural Sciences Foundation ; National Natural Sciences Foundation of China ; Beijing Natural Sciences Foundation
研究领域[WOS]Biotechnology & Applied Microbiology ; Toxicology
关键词[WOS]TIE-2 LIGAND ANGIOPOIETIN-2 ; ENDOTHELIAL-CELLS ; EXPRESSION ; INFLAMMATION ; ANGIOGENESIS ; MORTALITY ; SEVERITY ; ISCHEMIA ; MARKERS ; SEPSIS
英文摘要

Coronary heart disease (CHD) is characterized by inflammatory process and endothelial dysfunction. To investigate angiopoietin-2 (Ang-2) profiles, we evaluated serum Ang-2 levels in different types of CHD in 166 subjects. Ang-2 was measured by enzyme-linked immunosorbent assay. Serum Ang-2 levels were significantly elevated in patients with CHD and gradually increased with advance of CHD. Ang-2 was positively correlated with Gensini scores and hs-CRP. Ang-2 might have potential implication in detecting and monitoring the progression of CHD.

语种英语
所属项目编号81070260 ; 31070948 ; 7102099 ; 7122200
资助者National Natural Sciences Foundation of China ; Beijing Natural Sciences Foundation ; National Natural Sciences Foundation of China ; Beijing Natural Sciences Foundation
WOS记录号WOS:000311681100008
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59516
Collection北京大学第三临床医学院_心血管内科
作者单位1.Peking Univ, Hosp 3, Dept Cardiol, Beijing 100191, Peoples R China
2.Minist Hlth, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, Beijing, Peoples R China
3.Capital Med Univ, Beijing Chao Yang Hosp, Ctr Heart, Beijing, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Cell Biol, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Wang, Xin,Yong, Huijuan,Mi, Lin,et al. Changes and significance of serum angiopoietin-2 levels in patients with coronary heart disease[J]. BIOMARKERS,2012,17(8):745-749.
APA Wang, Xin.,Yong, Huijuan.,Mi, Lin.,Bai, Yun.,Guo, Lijun.,...&Zhang, Yongzhen.(2012).Changes and significance of serum angiopoietin-2 levels in patients with coronary heart disease.BIOMARKERS,17(8),745-749.
MLA Wang, Xin,et al."Changes and significance of serum angiopoietin-2 levels in patients with coronary heart disease".BIOMARKERS 17.8(2012):745-749.
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