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学科主题临床医学
Coagulation and Fibrinolysis Index Profile in Patients with ANCA-Associated Vasculitis
Ma, Tian-Tian1,2,3; Huang, Yi-Min1,2,3; Wang, Chen1,2,3; Zhao, Ming-Hui1,2,3,4; Chen, Min1,2,3
刊名PLOS ONE
2014-05-19
DOI10.1371/journal.pone.0097843
9期:5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]SYSTEMIC NECROTIZING VASCULITIS ; WEGENERS-GRANULOMATOSIS ; RISK-FACTORS ; THROMBOSIS ; COMPLEMENT ; REMISSION
英文摘要

Background: Previous studies observed the high prevalence of venous thromboembolism in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). The current study analyzed the coagulation and fibrinolysis index profile in AAV patients.

Methods: The current study recruited 321 AAV patients in active stage and 78 AAV patients in quiescent stage. Coagulation and fibrinolysis index profiles in these AAV patients were analysed, and their associations with various clinical and pathological parameters were further investigated.

Results: The circulating levels of D-dimer, fibrin degradation products and platelet count were significantly higher in AAV patients in active stage compared with those in remission [0.8 (0.4, 1.5) mg/L vs. 0.28 (0.2, 0.55) mg/L, P<0.05; 5.6 (5.0, 10.0) mg/L vs. 1.9 (1.2, 2.8) mg/L, P<0.05; 269 +/- 127 x 10(9)/L vs. 227 +/- 80 x 10(9)/L, P<0.05, respectively]. Among the 321 AAV patients in active stage, compared with patients with normal levels of D-dimer, patients with elevated D-dimer levels had significantly higher levels of initial serum creatinine, erythrocyte sedimentation rate, C reactive protein and the Birmingham Vasculitis Activity Scores (P = 0.014, P<0.001, P<0.001, P = 0.002, respectively). Moreover, correlation analysis showed that the levels of D-dimer correlated with erythrocyte sedimentation rate and C reactive protein levels (r = 0.384, P<0.001; r = 0.380, P<0.001, respectively).

Conclusion: Patients with active AAV are in hypercoagulable states, and circulating levels of D-dimer are associated with disease activity of AAV.

语种英语
WOS记录号WOS:000340948600081
项目编号2012CB517702 ; 81370829 ; 81021004 ; 2011BAI10B04
资助机构Chinese 973 project ; National Natural Science Fund ; "National Key Technology Research and Development (R&amp ; D) Program" of the Ministry of Science and Technology of China
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59519
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
2.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
3.Peking Univ, Hosp 1, Inst Nephrol, Dept Med,Renal Div, Beijing 100871, Peoples R China
4.Peking Univ, Key Lab Chron Kidney Dis Prevent & Treatment, Minist Educ, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Ma, Tian-Tian,Huang, Yi-Min,Wang, Chen,et al. Coagulation and Fibrinolysis Index Profile in Patients with ANCA-Associated Vasculitis[J]. PLOS ONE,2014,9(5).
APA Ma, Tian-Tian,Huang, Yi-Min,Wang, Chen,Zhao, Ming-Hui,&Chen, Min.(2014).Coagulation and Fibrinolysis Index Profile in Patients with ANCA-Associated Vasculitis.PLOS ONE,9(5).
MLA Ma, Tian-Tian,et al."Coagulation and Fibrinolysis Index Profile in Patients with ANCA-Associated Vasculitis".PLOS ONE 9.5(2014).
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