北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科  > 期刊论文
学科主题: 临床医学
题名:
Coagulation and Fibrinolysis Index Profile in Patients with ANCA-Associated Vasculitis
作者: Ma, Tian-Tian1,2,3; Huang, Yi-Min1,2,3; Wang, Chen1,2,3; Zhao, Ming-Hui1,2,3,4; Chen, Min1,2,3
刊名: PLOS ONE
发表日期: 2014-05-19
DOI: 10.1371/journal.pone.0097843
卷: 9, 期:5
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: SYSTEMIC NECROTIZING VASCULITIS ; WEGENERS-GRANULOMATOSIS ; RISK-FACTORS ; THROMBOSIS ; COMPLEMENT ; REMISSION
英文摘要:

Background: Previous studies observed the high prevalence of venous thromboembolism in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). The current study analyzed the coagulation and fibrinolysis index profile in AAV patients.

Methods: The current study recruited 321 AAV patients in active stage and 78 AAV patients in quiescent stage. Coagulation and fibrinolysis index profiles in these AAV patients were analysed, and their associations with various clinical and pathological parameters were further investigated.

Results: The circulating levels of D-dimer, fibrin degradation products and platelet count were significantly higher in AAV patients in active stage compared with those in remission [0.8 (0.4, 1.5) mg/L vs. 0.28 (0.2, 0.55) mg/L, P<0.05; 5.6 (5.0, 10.0) mg/L vs. 1.9 (1.2, 2.8) mg/L, P<0.05; 269 +/- 127 x 10(9)/L vs. 227 +/- 80 x 10(9)/L, P<0.05, respectively]. Among the 321 AAV patients in active stage, compared with patients with normal levels of D-dimer, patients with elevated D-dimer levels had significantly higher levels of initial serum creatinine, erythrocyte sedimentation rate, C reactive protein and the Birmingham Vasculitis Activity Scores (P = 0.014, P<0.001, P<0.001, P = 0.002, respectively). Moreover, correlation analysis showed that the levels of D-dimer correlated with erythrocyte sedimentation rate and C reactive protein levels (r = 0.384, P<0.001; r = 0.380, P<0.001, respectively).

Conclusion: Patients with active AAV are in hypercoagulable states, and circulating levels of D-dimer are associated with disease activity of AAV.

语种: 英语
所属项目编号: 2012CB517702 ; 81370829 ; 81021004 ; 2011BAI10B04
项目资助者: Chinese 973 project ; National Natural Science Fund ; "National Key Technology Research and Development (R&amp ; D) Program" of the Ministry of Science and Technology of China
WOS记录号: WOS:000340948600081
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59519
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
2.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
3.Peking Univ, Hosp 1, Inst Nephrol, Dept Med,Renal Div, Beijing 100871, Peoples R China
4.Peking Univ, Key Lab Chron Kidney Dis Prevent & Treatment, Minist Educ, Beijing 100871, Peoples R China

Recommended Citation:
Ma, Tian-Tian,Huang, Yi-Min,Wang, Chen,et al. Coagulation and Fibrinolysis Index Profile in Patients with ANCA-Associated Vasculitis[J]. PLOS ONE,2014,9(5).
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Ma, Tian-Tian]'s Articles
[Huang, Yi-Min]'s Articles
[Wang, Chen]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Ma, Tian-Tian]‘s Articles
[Huang, Yi-Min]‘s Articles
[Wang, Chen]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace