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学科主题: 药学
题名:
Structure characterization and immunocompetence of a glucan from the fruiting bodies of Cantharellus cibarius
作者: Han, Xiao-Qiang1,3; Li, Wei-Ji2; Ko, Chun-Hay3; Gao, Xiao-Ming2,4; Han, Chun-Xia5; Tu, Peng-Fei1
关键词: Cantharellus cibarius ; glucan ; immunocompetence ; splenocyte ; edible fungus
刊名: JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
发表日期: 2013-11-01
DOI: 10.1080/10286020.2013.810212
卷: 15, 期:11, 页:1204-1209
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: ALDITOL ACETATES ; POLYSACCHARIDES
英文摘要:

A protein-bound polysaccharide fraction (JBP-1) was obtained from the fruiting bodies of Cantharellus cibarius. Its chemical composition was studied by the cooperative usage of multiple chemical and spectral methods and characterized to be a fraction with a molecular weight of 4.8x10(5)Da and only composed of glucose. Methylation analysis revealed that the sugar residues in JBP-1 are existing as t-, 1,6-, and 1,3,6-linked Glcp sugar residues. The immunocompetence of the fraction was evaluated with the proliferation assay of mouse splenocytes, and the result revealed that JBP-1 could significantly stimulate the proliferation of mouse splenocytes in a dose-dependent manner, with p<0.001 at the concentration of 100g/ml and 30g/ml, p<0.05 at 10g/ml. These results give us a primary scientific evidence to further explore the pharmaceutical function of this mushroom.

语种: 英语
WOS记录号: WOS:000328316300010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59521
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Key Lab Infect & Immun Jiangsu Prov, Suzhou 215006, Peoples R China
2.Peking Univ Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
3.Soochow Univ, Inst Biol & Med Sci, Suzhou 215006, Peoples R China
4.Chinese Univ Hong Kong, Inst Chinese Med, State Key Lab Phytochem & Plant Resources West Ch, Shatin, Hong Kong, Peoples R China
5.Thermofisher Sci, Beijing 100085, Peoples R China

Recommended Citation:
Han, Xiao-Qiang,Li, Wei-Ji,Ko, Chun-Hay,et al. Structure characterization and immunocompetence of a glucan from the fruiting bodies of Cantharellus cibarius[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2013,15(11):1204-1209.
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