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Patients with risk factors have higher plasma levels of lysophosphatidic acid: a promising surrogate marker for blood platelet activation
Yao, Cun-Shan1; Yan, Shu-Gui2; Gao, Lian-Sheng3; Sun, Zhen-Rong2; Liu, Feng4; Jiang, Bo1; Wang, Hai-Bin1; Wu, Qi-Zhuan5
关键词risk factor aspirin lysophosphatidic acid biomarker
刊名BLOOD COAGULATION & FIBRINOLYSIS
2014-06-01
DOI10.1097/MBC.0000000000000034
25期:4页:322-325
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology
研究领域[WOS]Hematology
关键词[WOS]RECEPTORS ; ASPIRIN ; DISEASE ; CELLS
英文摘要

Although basic medical studies have shown that lysophosphatidic acid (LPA) has an important relationship to activated blood platelets, we know little about this from clinical experience. This pilot study examined plasma LPA levels in patients with a risk of thrombotic events and evaluated the effects of aspirin on plasma LPA levels. In this basically cross-sectional study, we recruited 1352 patients with either hypertension or hyperlipidemia and 670 controls without any risk factors. Patients with risk factors had significantly higher plasma LPA levels than controls, the mean of LPA = 3.12 +/- 2.24 vs. 2.57 +/- 1.96 mu mol/l, P < 0.001. The patients who had been taking aspirin had relatively lower plasma LPA levels compared with those who did not take aspirin, chi(2) = 43.8, odds ratio (OR) [95% confidence interval (CI)] = 2.76 (2.03-3.75). For the hypertension group, chi(2) = 23.1, OR (95% CI) = 3.44 (2.03-5.82), P < 0.001; for the hyperlipidemia group, chi(2) = 22.9, OR (95% CI) = 2.53 (1.72-3.74), P < 0.001. Patients with a risk factor had higher plasma LPA levels compared with controls. Administration of aspirin may decrease elevated plasma LPA levels. This pilot clinical observation indicates that plasma LPA is worth to be studied further.

语种英语
WOS记录号WOS:000335956900006
项目编号YJ2009330
资助机构First Affiliated Hospital of Chinese Army General Hospital
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59529
专题北京大学第一临床医学院_神经内科
作者单位1.Chinese Army Gen Hosp, Dept Neurol, Affiliated Hosp 1, Beijing 100048, Peoples R China
2.Peoples Hosp DongChang Dist, Dept Internal Med, Tonghua City, Jilin Province, Peoples R China
3.8th Hosp Shijiazhuang, Dept Internal Med, Shijiazhuang, Hebei Province, Peoples R China
4.Peoples Hosp Rui Cheng Cty, Dept Neurol, Ruicheng Cty, Shanxi Province, Peoples R China
5.Peking Univ, Dept Neurol, Hosp 1, Beijing 100871, Peoples R China
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GB/T 7714
Yao, Cun-Shan,Yan, Shu-Gui,Gao, Lian-Sheng,et al. Patients with risk factors have higher plasma levels of lysophosphatidic acid: a promising surrogate marker for blood platelet activation[J]. BLOOD COAGULATION &amp; FIBRINOLYSIS,2014,25(4):322-325.
APA Yao, Cun-Shan.,Yan, Shu-Gui.,Gao, Lian-Sheng.,Sun, Zhen-Rong.,Liu, Feng.,...&Wu, Qi-Zhuan.(2014).Patients with risk factors have higher plasma levels of lysophosphatidic acid: a promising surrogate marker for blood platelet activation.BLOOD COAGULATION & FIBRINOLYSIS,25(4),322-325.
MLA Yao, Cun-Shan,et al."Patients with risk factors have higher plasma levels of lysophosphatidic acid: a promising surrogate marker for blood platelet activation".BLOOD COAGULATION & FIBRINOLYSIS 25.4(2014):322-325.
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