IR@PKUHSC  > 北京大学基础医学院  > 神经生物学系
学科主题基础医学
Nocistatin potentiates electroacupuncture antinociceptive effects and reverses chronic tolerance to electroacupuncture in mice
Huang, C; Long, H; Shi, YS; Han, JS; Wan, Y
关键词nocistatin electroacupuncture analgesia nociception tolerance
刊名NEUROSCIENCE LETTERS
2003-10-23
DOI10.1016/S0304-3940(03)00863-2
350期:2页:93-96
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]ENDOGENOUS ORPHANIN FQ ; MORPHINE ANALGESIA ; RECEPTOR ; PEPTIDE ; RATS ; INVOLVEMENT ; BRAIN ; GENE
英文摘要

Nocistatin (NST) and nociception/orphanin FQ (OFQ) are peptides derived from the same precursor that play opposing roles in pain modulation. OFQ antagonizes morphine analgesia and electroacupuncture (EA)-induced antinociceptive effect. The present study investigates whether NST potentiates EA-induced antinociceptive effect and reverses chronic tolerance to EA in mice. Injection of NST (0.5, 5.0 and 50.0 ng) intracerebroventricularly had no effect on basal thermal latency, but produced a dose-dependent potentiation of EA-induced antinociceptive effect in mice with the maximum response at 5.0 ng. NST (5.0 ng) partly reversed chronic tolerance to EA. These results suggest that NST in the brain might play roles in EA-induced antinociceptive effect and the development of chronic tolerance to EA in mice. (C) 2003 Published by Elsevier Ireland Ltd.

语种英语
WOS记录号WOS:000185531700007
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59532
专题北京大学基础医学院_神经生物学系
作者单位1.Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Gannan Med Coll, Dept Physiol, Ganzhou 341000, Jiangxi, Peoples R China
推荐引用方式
GB/T 7714
Huang, C,Long, H,Shi, YS,et al. Nocistatin potentiates electroacupuncture antinociceptive effects and reverses chronic tolerance to electroacupuncture in mice[J]. NEUROSCIENCE LETTERS,2003,350(2):93-96.
APA Huang, C,Long, H,Shi, YS,Han, JS,&Wan, Y.(2003).Nocistatin potentiates electroacupuncture antinociceptive effects and reverses chronic tolerance to electroacupuncture in mice.NEUROSCIENCE LETTERS,350(2),93-96.
MLA Huang, C,et al."Nocistatin potentiates electroacupuncture antinociceptive effects and reverses chronic tolerance to electroacupuncture in mice".NEUROSCIENCE LETTERS 350.2(2003):93-96.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Nocistatin potentiat(99KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Huang, C]的文章
[Long, H]的文章
[Shi, YS]的文章
百度学术
百度学术中相似的文章
[Huang, C]的文章
[Long, H]的文章
[Shi, YS]的文章
必应学术
必应学术中相似的文章
[Huang, C]的文章
[Long, H]的文章
[Shi, YS]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Nocistatin potentiates electroacupuncture antinociceptive effects and reverses chronic tolerance to electroacupuncture in mice.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。