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学科主题: 基础医学
题名:
Nocistatin potentiates electroacupuncture antinociceptive effects and reverses chronic tolerance to electroacupuncture in mice
作者: Huang, C; Long, H; Shi, YS; Han, JS; Wan, Y
关键词: nocistatin ; electroacupuncture ; analgesia ; nociception ; tolerance
刊名: NEUROSCIENCE LETTERS
发表日期: 2003-10-23
DOI: 10.1016/S0304-3940(03)00863-2
卷: 350, 期:2, 页:93-96
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: ENDOGENOUS ORPHANIN FQ ; MORPHINE ANALGESIA ; RECEPTOR ; PEPTIDE ; RATS ; INVOLVEMENT ; BRAIN ; GENE
英文摘要:

Nocistatin (NST) and nociception/orphanin FQ (OFQ) are peptides derived from the same precursor that play opposing roles in pain modulation. OFQ antagonizes morphine analgesia and electroacupuncture (EA)-induced antinociceptive effect. The present study investigates whether NST potentiates EA-induced antinociceptive effect and reverses chronic tolerance to EA in mice. Injection of NST (0.5, 5.0 and 50.0 ng) intracerebroventricularly had no effect on basal thermal latency, but produced a dose-dependent potentiation of EA-induced antinociceptive effect in mice with the maximum response at 5.0 ng. NST (5.0 ng) partly reversed chronic tolerance to EA. These results suggest that NST in the brain might play roles in EA-induced antinociceptive effect and the development of chronic tolerance to EA in mice. (C) 2003 Published by Elsevier Ireland Ltd.

语种: 英语
WOS记录号: WOS:000185531700007
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59532
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Gannan Med Coll, Dept Physiol, Ganzhou 341000, Jiangxi, Peoples R China

Recommended Citation:
Huang, C,Long, H,Shi, YS,et al. Nocistatin potentiates electroacupuncture antinociceptive effects and reverses chronic tolerance to electroacupuncture in mice[J]. NEUROSCIENCE LETTERS,2003,350(2):93-96.
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