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学科主题: 临床医学
题名:
7-Nitroindazole and posthypoxic ventilatory behavior in the A/J and C57BL/6J mouse strains
作者: Price, ER; Han, F; Dick, TE; Strohl, KP
关键词: short-term potentiation ; nitric oxide synthase ; ventilation ; respiratory control ; genetics
刊名: JOURNAL OF APPLIED PHYSIOLOGY
发表日期: 2003-09-01
DOI: 10.1152/japplphysiol.00166.2003
卷: 95, 期:3, 页:1097-1104
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Physiology ; Sport Sciences
研究领域[WOS]: Physiology ; Sport Sciences
关键词[WOS]: NITRIC-OXIDE SYNTHASE ; MUTANT MICE DEFICIENT ; NUCLEUS-TRACTUS-SOLITARII ; RESPIRATORY RESPONSES ; OXYGEN-CONSUMPTION ; HEART-FAILURE ; CAROTID-BODY ; HYPOXIA ; RAT ; INSTABILITY
英文摘要:

Periodic breathing (PB) is a fundamental breathing pattern in many common cardiopulmonary illnesses. The finding of PB in C57BL/6J (B6) mice was previously ascribed to strain differences in posthypoxic ventilatory and frequency decline in the B6 mice (Han F, Subramanian S, Price ER, Nadeau J, and Strohl KP. J Appl Physiol 92: 1133-1140, 2002). We tested whether the induction of posthypoxic frequency decline in A/J mice, through administration of a neuronal nitric oxide synthase blocker [7-nitroindazole (7-NI); 60 mg/kg], would cause A/J mice to exhibit PB and/or alter PB expression in the B6 strain. Recordings of ventilatory behavior by the plethysmography method were made when unanesthetized B6 (n = 10) or A/J (n = 6) animals were reoxygenated with 100% O(2) or room air after exposure to 8% O(2). Before undergoing gas challenges, mice were given an intraperitoneal injection of either peanut oil alone ( vehicle) or 7-NI suspended in peanut oil. Compared with vehicle, both strains of mice exhibited posthypoxic frequency decline and the absence of short-term potentiation with 7-NI administration. B6 mice continued to exhibit posthypoxic PB; however, the PB was characterized by longer cycle and apnea length. In contrast, A/J mice did not show increased tendency toward posthypoxic PB with 7-NI. We conclude that 7-NI further differentiates the A/J and B6 strains in terms of PB and that strain-related differences in posthypoxic frequency decline are not primary determinants of this strain difference in the occurrence of PB. Metabolism was not associated with either the expression of posthypoxic ventilatory decline or PB. Furthermore, neuronal nitric oxide may be an organizing feature in the presence, length, and/or cycle length of apnea in the susceptible strain.

语种: 英语
WOS记录号: WOS:000184733800026
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59533
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Case Western Reserve Univ, Dept Med, Cleveland, OH 44106 USA
2.Beijing Univ, Peoples Hosp, Dept Med, Beijing 100044, Peoples R China

Recommended Citation:
Price, ER,Han, F,Dick, TE,et al. 7-Nitroindazole and posthypoxic ventilatory behavior in the A/J and C57BL/6J mouse strains[J]. JOURNAL OF APPLIED PHYSIOLOGY,2003,95(3):1097-1104.
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