|Papaverine improves sublingual blood flow in patients with septic shock|
|Li, Hongliang; Zhu, Xi; Yao, Gaiqi; Wang, Zongyu|
|关键词||Microcirculation Papaverine Sidestream dark-field imaging Septic shock Perfused vessel Microvascular flow index|
|刊名||JOURNAL OF SURGICAL RESEARCH|
|WOS标题词||Science & Technology|
|关键词[WOS]||MICROCIRCULATORY ALTERATIONS ; SEVERE SEPSIS ; THERAPY ; FAILURE|
Background: In recent years, microcirculatory blood flow alterations have been recognized to be stronger predictors of septic shock treatment outcomes than global hemodynamic variables.
Methods: In our self-controlled, interventional pilot clinical trial study, we investigated the effects of a single papaverine injection on the microcirculation in sepsis patients undergoing fluid resuscitation combined with vasopressor treatments. Fourteen septic shock patients admitted to the Peking University Third Hospital were included in the study, and each patient received 30 mg papaverine, which is the approximate dosage used to treat a conventional arterial spasm. Papaverine was administered as an intravenous bolus injection after systemic hemodynamic stabilization had been achieved by means of fluid resuscitation combined with dopamine and/or norepinephrine vasopressor medication. Baseline characteristics, as well as global hemodynamic and blood gas parameters, before and 60 min after papaverine injection were recorded and sublingual microcirculatory data at baseline and 15, 30, and 60 min after papaverine administration obtained using side-stream dark-field video microscopy.
Results: The perfused vessel density of small vessels was significantly increased 30 and 60 min after papaverine administration (P < 0.01), and the proportion of perfused small vessels (PPV), as well as the microvascular flow index, was significantly increased 30 min after papaverine (P < 0.05). There were no visible systemic effects, arrhythmia, or hypotension during the observation period in each patient.
Conclusions: In our pilot study, papaverine transiently improved sublingual microcirculatory blood flow without influencing systemic hemodynamics in patients with septic shock, who required vasoconstrictors to maintain blood pressure during fluid resuscitation. (C) 2015 Elsevier Inc. All rights reserved.
|作者单位||Peking Univ, Hosp 3, Dept Intens Care, Beijing 100191, Peoples R China|
|Li, Hongliang,Zhu, Xi,Yao, Gaiqi,et al. Papaverine improves sublingual blood flow in patients with septic shock[J]. JOURNAL OF SURGICAL RESEARCH,2015,195(1):271-276.|
|APA||Li, Hongliang,Zhu, Xi,Yao, Gaiqi,&Wang, Zongyu.(2015).Papaverine improves sublingual blood flow in patients with septic shock.JOURNAL OF SURGICAL RESEARCH,195(1),271-276.|
|MLA||Li, Hongliang,et al."Papaverine improves sublingual blood flow in patients with septic shock".JOURNAL OF SURGICAL RESEARCH 195.1(2015):271-276.|