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学科主题: 临床医学
题名:
Investigations on Colorectum Cancer Cell Lines and Nucleus by FTIR Spectroscopy
作者: Zhang Chao1; Sun Xue-jun1; Liu Dong1; Liu Wei3; Zheng Jian-bao1; Du Jun-kai1; Ling Xiao-feng4; Zhang Yuan-fu2; Xu Yi-zhuang2; Wu Jin-guang2
关键词: Cell line ; Cell nucleus ; Fourier transform infrared spectra
刊名: SPECTROSCOPY AND SPECTRAL ANALYSIS
发表日期: 2013-06-01
DOI: 10.3964/j.issn.1000-0593(2013)06-1496-05
卷: 33, 期:6, 页:1496-1500
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Spectroscopy
研究领域[WOS]: Spectroscopy
关键词[WOS]: TRANSFORM INFRARED-SPECTROSCOPY ; TISSUES
英文摘要:

The purpose of this study is to establish the cell and subcellular basis for the diagnosis of colorectal cancer by researching the FTIR( Fourier transform infrared spectra) of the normal tissue (30 cases) and cell line (SW 620), normal nuclei and malignant nucleus with Fourier transform infrared spectrum technology. The results of the peak position and the relative intensity obtained by statistical analysis indicate that the bands at 2 925, 1 240 and 1 085 cm(-1) shifted toward higher wavenumber (p< 0. 05) in the FTIR spectra of cell lines (SW 620) and malignant nucleus. The 1 400 cm(-1) band shifted toward lower wave number (p<0. 05). The relative intensity ratios of I-1650/I-1460, I-1400/I-1460 and I-1240/I-1460 increased in the FTIR spectra of cell lines (SW 620) compared with normal tissue (p<0. 05), but inversely, 11740/11460 decreased significantly (p<0. 01). The relative intensity ratios of I-1650/I-1460, I-1400/I-1460 and I-1240/I-1460 also increased in the FTIR spectra of the malignant nucleus. The above statistic differences are the basis for diagnosing colorectum cancer by FTIR spectroscopy.

语种: 中文
WOS记录号: WOS:000320012600012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59537
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Beijing 100191, Peoples R China
2.Xi An Jiao Tong Univ, Hosp 1, Xian 710061, Peoples R China
3.Peking Univ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China
4.Liaoning Univ Tradit Chinese Med, Coll Pharm, Dalian 116600, Peoples R China

Recommended Citation:
Zhang Chao,Sun Xue-jun,Liu Dong,et al. Investigations on Colorectum Cancer Cell Lines and Nucleus by FTIR Spectroscopy[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS,2013,33(6):1496-1500.
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