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学科主题: 临床医学
题名:
Recent duplications drive rapid diversification of trypsin genes in 12 Drosophila
作者: Li, Luolan1; Memon, Shabana1; Fan, Yuanchu2; Yang, Sihai1; Tan, Shengjun1,3
关键词: Trypsin ; Duplication ; Deletion ; Food resources ; Adaptive evolution
刊名: GENETICA
发表日期: 2012-09-01
DOI: 10.1007/s10709-012-9682-5
卷: 140, 期:7-9, 页:297-305
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity
研究领域[WOS]: Genetics & Heredity
关键词[WOS]: HOST SPECIALIZATION ; ADAPTIVE EVOLUTION ; SERINE-PROTEASE ; DIVERGENCE ; MELANOGASTER ; EXPRESSION ; GENOMES ; FAMILY ; CONSERVATION ; SELECTION
英文摘要:

Trypsin participates in many fundamental biological processes, the most notably in digesting food. The 12 species of Drosophila provide a great opportunity to analyze the duplication pattern of trypsins and their association with dietary changes. Here, we find that the trypsin family expands dramatically after speciation. The duplication events are strongly related to the host preferences, with significantly more copy numbers in species breeding on rotting fruits. Temporal analysis of the duplication events indicates that the occurrences of these events are not simultaneous, but rather correlate to the ecological change or host shift. Furthermore, we find that the specialists and generalists have different adaptive selections, which is revealed by dynamic duplication and/or deletion and relatively high Ka/Ks values on the duplicated events in specialists. Our findings suggest that the duplication of trypsin genes has played an important role in the adaption of Drosophila to the diverse ecosystems.

语种: 英语
所属项目编号: 30970198 ; 0930008 ; J1103512
项目资助者: National Natural Science Foundation of China ; Qing Lan Project
WOS记录号: WOS:000311392600003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59539
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Nanjing Univ, Dept Biol, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Jiangsu, Peoples R China
2.Peking Univ, Hosp 1, Beijing 100871, Peoples R China
3.Chinese Acad Sci, Key Lab Zool Systemat & Evolut, Inst Zool, Beijing 100101, Peoples R China

Recommended Citation:
Li, Luolan,Memon, Shabana,Fan, Yuanchu,et al. Recent duplications drive rapid diversification of trypsin genes in 12 Drosophila[J]. GENETICA,2012,140(7-9):297-305.
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