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Recent duplications drive rapid diversification of trypsin genes in 12 Drosophila
Li, Luolan1; Memon, Shabana1; Fan, Yuanchu2; Yang, Sihai1; Tan, Shengjun1,3
关键词Trypsin Duplication Deletion Food resources Adaptive evolution
刊名GENETICA
2012-09-01
DOI10.1007/s10709-012-9682-5
140期:7-9页:297-305
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity
研究领域[WOS]Genetics & Heredity
关键词[WOS]HOST SPECIALIZATION ; ADAPTIVE EVOLUTION ; SERINE-PROTEASE ; DIVERGENCE ; MELANOGASTER ; EXPRESSION ; GENOMES ; FAMILY ; CONSERVATION ; SELECTION
英文摘要

Trypsin participates in many fundamental biological processes, the most notably in digesting food. The 12 species of Drosophila provide a great opportunity to analyze the duplication pattern of trypsins and their association with dietary changes. Here, we find that the trypsin family expands dramatically after speciation. The duplication events are strongly related to the host preferences, with significantly more copy numbers in species breeding on rotting fruits. Temporal analysis of the duplication events indicates that the occurrences of these events are not simultaneous, but rather correlate to the ecological change or host shift. Furthermore, we find that the specialists and generalists have different adaptive selections, which is revealed by dynamic duplication and/or deletion and relatively high Ka/Ks values on the duplicated events in specialists. Our findings suggest that the duplication of trypsin genes has played an important role in the adaption of Drosophila to the diverse ecosystems.

语种英语
WOS记录号WOS:000311392600003
项目编号30970198 ; 0930008 ; J1103512
资助机构National Natural Science Foundation of China ; Qing Lan Project
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59539
专题北京大学第一临床医学院
作者单位1.Nanjing Univ, Dept Biol, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Jiangsu, Peoples R China
2.Peking Univ, Hosp 1, Beijing 100871, Peoples R China
3.Chinese Acad Sci, Key Lab Zool Systemat & Evolut, Inst Zool, Beijing 100101, Peoples R China
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GB/T 7714
Li, Luolan,Memon, Shabana,Fan, Yuanchu,et al. Recent duplications drive rapid diversification of trypsin genes in 12 Drosophila[J]. GENETICA,2012,140(7-9):297-305.
APA Li, Luolan,Memon, Shabana,Fan, Yuanchu,Yang, Sihai,&Tan, Shengjun.(2012).Recent duplications drive rapid diversification of trypsin genes in 12 Drosophila.GENETICA,140(7-9),297-305.
MLA Li, Luolan,et al."Recent duplications drive rapid diversification of trypsin genes in 12 Drosophila".GENETICA 140.7-9(2012):297-305.
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