IR@PKUHSC  > 北京大学第一临床医学院  > 内分泌内科
学科主题临床医学
Association of Genetic Variants with Isolated Fasting Hyperglycaemia and Isolated Postprandial Hyperglycaemia in a Han Chinese Population
Kong, Xiaomu1; Hong, Jing1; Chen, Ying2; Chen, Li3; Zhao, Zhigang4; Li, Qiang5; Ge, Jiapu6; Chen, Gang7; Guo, Xiaohui8; Lu, Juming9; Weng, Jianping10; Jia, Weiping11; Ji, Linong12; Xiao, Jianzhong1; Shan, Zhongyan13; Liu, Jie14; Tian, Haoming15; Ji, Qiuhe16; Zhu, Dalong17; Zhou, Zhiguang18; Shan, Guangliang19; Yang, Wenying1
刊名PLOS ONE
2013-08-19
DOI10.1371/journal.pone.0071399
8期:8
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者Chinese Medical Association Foundation ; Chinese Diabetes Society ; National 973 Program ; China Postdoctoral Science Foundation Grant ; Chinese Medical Association Foundation ; Chinese Diabetes Society ; National 973 Program ; China Postdoctoral Science Foundation Grant
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]GENOME-WIDE ASSOCIATION ; TYPE-2 DIABETES RISK ; FTO GENE ; SUSCEPTIBILITY LOCI ; INSULIN SENSITIVITY ; TRIGLYCERIDE LEVELS ; COMMON VARIANTS ; CONFERS RISK ; FAT MASS ; OBESITY
英文摘要

Background: Though multiple single nucleotide polymorphisms (SNPs) associated with type 2 diabetes have been identified, the genetic bases of isolated fasting hyperglycaemia (IFH) and isolated postprandial hyperglycaemia (IPH) were still unclear. In present study, we aimed to investigate the association of genome-wide association study-validated genetic variants and IFH or IPH in Han Chinese.

Methods/Principal Findings: We genotyped 27 validated SNPs in 6,663 unrelated individuals comprising 341 IFH, 865 IPH, 1,203 combined fasting hyperglycaemia and postprandial hyperglycaemia, and 4,254 normal glycaemic subjects of Han ancestry. The distributions of genotype frequencies of FTO, CDKAL1 and GCKR were significant different between individuals with IFH and those with IPH (SNP(p(trend)): rs8050136(0.0024), rs9939609(0.0049), rs7756992(0.0122), rs780094(0.0037)). Risk allele of FTO specifically increased the risk of IFH (rs8050136: OR 1.403 [95% CI 1.125-1.750], p = 0.0027; rs9939609: 1.398 [1.120-1.744], p = 0.0030). G allele of CDKAL1 specifically increased the risk of IPH (1.217 [1.092-1.355], p = 0.0004). G allele of GCKR increased the risk of IFH (1.167 [0.999-1.362], p = 0.0513), but decreased the risk of IPH (0.891 [0.801-0.991], p = 0.0331). In addition, TCF7L2 and KCNQ1 increased the risk of both IFH and IPH. When combined, each additional risk allele associated with IFH increased the risk for IFH by 1.246-fold (p < 0.0001), while each additional risk allele associated with IPH increased the risk for IPH by 1.190-fold (p < 0.0001).

Conclusion/Significance: Our results indicate that genotype distributions of variants from FTO, GCKR, CDKAL1 were different between IPH and IFH in Han Chinese. Variants of genes modulating insulin sensitivity (FTO, GCKR) contributed to the risk of IFH, while variants of genes related to beta cell function (CDKAL1) increase the risk of IPH.

语种英语
所属项目编号2011CB504001 ; 2012M520200
资助者Chinese Medical Association Foundation ; Chinese Diabetes Society ; National 973 Program ; China Postdoctoral Science Foundation Grant ; Chinese Medical Association Foundation ; Chinese Diabetes Society ; National 973 Program ; China Postdoctoral Science Foundation Grant
WOS记录号WOS:000323425700047
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59545
专题北京大学第一临床医学院_内分泌内科
作者单位1.Fujian Prov Hosp, Dept Endocrinol, Fuzhou, Fujian, Peoples R China
2.Peking Univ, Peoples Hosp, Beijing 100871, Peoples R China
3.China Japan Friendship Hosp, Dept Endocrinol, Key Lab Diabet Prevent & Control, Beijing, Peoples R China
4.Beijing Genet Inst, Dept Bioinformat, Shenzhen, Guangdong, Peoples R China
5.Shandong Univ, Dept Endocrinol, Qilu Hosp, Jinan, Shandong, Peoples R China
6.Henan Prov Peoples Hosp, Dept Endocrinol, Zhengzhou, Henan, Peoples R China
7.Harbin Med Univ, Dept Endocrinol, Affiliated Hosp 2, Harbin, Heilongjiang, Peoples R China
8.Xinjiang Uygur Autonomous Reg Hosp, Dept Endocrinol, Urumqi, Xinjiang, Peoples R China
9.Peking Univ, Dept Endocrinol, Hosp 1, Beijing 100871, Peoples R China
10.Chinese Peoples Liberat Army Gen Hosp, Dept Endocrinol, Beijing, Peoples R China
11.Sun Yat Sen Univ, Dept Endocrinol, Affiliated Hosp 3, Guangzhou 510275, Guangdong, Peoples R China
12.Shanghai Jiao Tong Univ, Dept Endocrinol, Peoples Hosp 6, Shanghai 200030, Peoples R China
13.China Med Univ, Dept Endocrinol, Hosp 1, Shenyang, Liaoning, Peoples R China
14.Shanxi Prov Peoples Hosp, Dept Endocrinol, Taiyuan, Shanxi, Peoples R China
15.Sichuan Univ, Dept Endocrinol, West China Hosp, Chengdu 610064, Sichuan, Peoples R China
16.Fourth Mil Med Univ, Dept Endocrinol, Xijing Hosp, Xian 710032, Shaanxi, Peoples R China
17.Nanjing Univ, Dept Endocrinol, Drum Tower Hosp, Sch Med, Nanjing 210008, Jiangsu, Peoples R China
18.Xiangya Second Hosp, Dept Endocrinol, Changsha, Hunan, Peoples R China
19.Peking Union Med Coll, Dept Epidemiol, Beijing 100021, Peoples R China
推荐引用方式
GB/T 7714
Kong, Xiaomu,Hong, Jing,Chen, Ying,et al. Association of Genetic Variants with Isolated Fasting Hyperglycaemia and Isolated Postprandial Hyperglycaemia in a Han Chinese Population[J]. PLOS ONE,2013,8(8).
APA Kong, Xiaomu.,Hong, Jing.,Chen, Ying.,Chen, Li.,Zhao, Zhigang.,...&Yang, Wenying.(2013).Association of Genetic Variants with Isolated Fasting Hyperglycaemia and Isolated Postprandial Hyperglycaemia in a Han Chinese Population.PLOS ONE,8(8).
MLA Kong, Xiaomu,et al."Association of Genetic Variants with Isolated Fasting Hyperglycaemia and Isolated Postprandial Hyperglycaemia in a Han Chinese Population".PLOS ONE 8.8(2013).
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