IR@PKUHSC  > 北京大学基础医学院  > 北京大学干细胞研究中心
学科主题基础医学
In vivo gamma imaging of the secondary tumors of transplanted human fetal striatum neural stem cells-derived primary tumor cells
He, Qihua1,2; Liu, Zhaofei4; Jia, Bing4; Li, Xiaoxia1,2; Shi, Jiyun4; Zhang, Jun1,2; Lan, Feng1,2; Yang, Zhi3; Liu, Yinan1,2; Shen, Li1,2; Wang, Fan4
关键词gamma imaging integrin alpha(v)beta(3) neural stem cell tumorigenesis technetium-99m-labeled Arg-Gly-Asp peptide
刊名NEUROREPORT
2008-07-02
19期:10页:1009-1014
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]CYCLIC RGDFK DIMER ; HUMAN BLASTOCYSTS ; LINES ; DIFFERENTIATE ; EXPRESSION ; MODEL
英文摘要

This study describes gamma-imaging of the secondary tumors from the transplanted human fetal striatum neural stem cells-derived primary tumor cells in nude mice. The subcutaneous primary tumors were detected to express integrin alpha(v)beta(3) and the corresponding cells were isolated and enriched in vitro, then transplanted to the nude mice. The technetium-99m-labeled Arg-Gly-Asp peptide, with high affinity to integrin alpha(v)beta(3), was prepared for biodistribution and gamma-imaging. The secondary tumors were readily visualized at l-h postinjection, and the tumor uptake of radiotracer was similar to that of positive control animals transplanted with U87MG human glioma cells. The tumor specificity of radiotracer was demonstrated by blocking experiment. We concluded that gamma-imaging is a promising approach in imaging the tumorigenesis of transplanted stem cells in vivo.

语种英语
WOS记录号WOS:000257488500003
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59546
Collection北京大学基础医学院_北京大学干细胞研究中心
作者单位1.Peking Univ, Hlth Sci Ctr, Stem Cell Res Ctr, Beijing 100871, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Cell Biol, Beijing 100871, Peoples R China
3.Peking Univ, Oncol Sch, Dept Nucl Med, Beijing 100871, Peoples R China
4.Peking Univ, Oncol Sch, Med Isotopes Res Ctr, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
He, Qihua,Liu, Zhaofei,Jia, Bing,et al. In vivo gamma imaging of the secondary tumors of transplanted human fetal striatum neural stem cells-derived primary tumor cells[J]. NEUROREPORT,2008,19(10):1009-1014.
APA He, Qihua.,Liu, Zhaofei.,Jia, Bing.,Li, Xiaoxia.,Shi, Jiyun.,...&Wang, Fan.(2008).In vivo gamma imaging of the secondary tumors of transplanted human fetal striatum neural stem cells-derived primary tumor cells.NEUROREPORT,19(10),1009-1014.
MLA He, Qihua,et al."In vivo gamma imaging of the secondary tumors of transplanted human fetal striatum neural stem cells-derived primary tumor cells".NEUROREPORT 19.10(2008):1009-1014.
Files in This Item: Download All
File Name/Size DocType Version Access License
In vivo gamma imagin(277KB)期刊论文出版稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[He, Qihua]'s Articles
[Liu, Zhaofei]'s Articles
[Jia, Bing]'s Articles
百度学术
百度学术Similar articles in
[He, Qihua]'s Articles
[Liu, Zhaofei]'s Articles
[Jia, Bing]'s Articles
必应学术
必应学术Similar articles in
[He, Qihua]'s Articles
[Liu, Zhaofei]'s Articles
[Jia, Bing]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: In vivo gamma imaging of the secondary tumors of transplanted human fetal striatum neural stem cells-derived primary tumor cells.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.