IR@PKUHSC  > 基础医学院  > 北京大学干细胞研究中心
学科主题基础医学
In vivo gamma imaging of the secondary tumors of transplanted human fetal striatum neural stem cells-derived primary tumor cells
He, Qihua1,2; Liu, Zhaofei4; Jia, Bing4; Li, Xiaoxia1,2; Shi, Jiyun4; Zhang, Jun1,2; Lan, Feng1,2; Yang, Zhi3; Liu, Yinan1,2; Shen, Li1,2; Wang, Fan4
关键词gamma imaging integrin alpha(v)beta(3) neural stem cell tumorigenesis technetium-99m-labeled Arg-Gly-Asp peptide
刊名NEUROREPORT
2008-07-02
19期:10页:1009-1014
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]CYCLIC RGDFK DIMER ; HUMAN BLASTOCYSTS ; LINES ; DIFFERENTIATE ; EXPRESSION ; MODEL
英文摘要

This study describes gamma-imaging of the secondary tumors from the transplanted human fetal striatum neural stem cells-derived primary tumor cells in nude mice. The subcutaneous primary tumors were detected to express integrin alpha(v)beta(3) and the corresponding cells were isolated and enriched in vitro, then transplanted to the nude mice. The technetium-99m-labeled Arg-Gly-Asp peptide, with high affinity to integrin alpha(v)beta(3), was prepared for biodistribution and gamma-imaging. The secondary tumors were readily visualized at l-h postinjection, and the tumor uptake of radiotracer was similar to that of positive control animals transplanted with U87MG human glioma cells. The tumor specificity of radiotracer was demonstrated by blocking experiment. We concluded that gamma-imaging is a promising approach in imaging the tumorigenesis of transplanted stem cells in vivo.

语种英语
WOS记录号WOS:000257488500003
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59546
专题基础医学院_北京大学干细胞研究中心
作者单位1.Peking Univ, Hlth Sci Ctr, Stem Cell Res Ctr, Beijing 100871, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Cell Biol, Beijing 100871, Peoples R China
3.Peking Univ, Oncol Sch, Dept Nucl Med, Beijing 100871, Peoples R China
4.Peking Univ, Oncol Sch, Med Isotopes Res Ctr, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
He, Qihua,Liu, Zhaofei,Jia, Bing,et al. In vivo gamma imaging of the secondary tumors of transplanted human fetal striatum neural stem cells-derived primary tumor cells[J]. NEUROREPORT,2008,19(10):1009-1014.
APA He, Qihua.,Liu, Zhaofei.,Jia, Bing.,Li, Xiaoxia.,Shi, Jiyun.,...&Wang, Fan.(2008).In vivo gamma imaging of the secondary tumors of transplanted human fetal striatum neural stem cells-derived primary tumor cells.NEUROREPORT,19(10),1009-1014.
MLA He, Qihua,et al."In vivo gamma imaging of the secondary tumors of transplanted human fetal striatum neural stem cells-derived primary tumor cells".NEUROREPORT 19.10(2008):1009-1014.
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