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Improved outcome with hematopoietic stem cell transplantation in a poor prognostic subgroup of patients with mixed-lineage-leukemia-rearranged acute leukemia: results from a prospective, multi-center study
Wang Yu1; Liu Qi-Fa2; Qin Ya-Zhen1; Liu Dai-Hong1; Xu Lan-Ping1; Jiang Bin1,2; Jiang Qian1,2; Dai Min2; Yu Si-Jian2; Jiang Xin-Miao1,2; Liu Yan-Rong1; Huang Xiao-Jun1
刊名AMERICAN JOURNAL OF HEMATOLOGY
2014-02-01
DOI10.1002/ajh.23595
89期:2页:130-136
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology
研究领域[WOS]Hematology
关键词[WOS]ACUTE LYMPHOBLASTIC-LEUKEMIA ; ACUTE MYELOID-LEUKEMIA ; DONOR LYMPHOCYTE INFUSION ; MLL GENE REARRANGEMENTS ; STAGE ACUTE-LEUKEMIA ; ADULT PATIENTS ; ONCOLOGY GROUP ; RELAPSE ; CLASSIFICATION ; TRIAL
英文摘要

The purpose of this study is to define the role for allogeneic hematopoietic stem cell transplantation (allo-HSCT) in mixed-lineage-leukemia (MLL)-rearranged acute leukemia, which is now poorly understood. A prospective, multi-center cohort study to determine whether allo-HSCT could decrease relapse rates and improve long-term survival of MLL+ leukemia patients was performed. Fifty-six consecutive patients diagnosed with MLL-rearranged acute leukemia undergoing allo-HSCT from two transplant centers in China were enrolled between October 2007 and October 2012. The trial was registered at as # ChiCTR-ONC-12002739. The incidences of grades II to IV acute graft versus host disease (aGVHD) and of grades III and IV aGVHD were 28.8% (CI, 16.87-40.8%), and 14.2% (CI, 5.4-23.0%), respectively. The cumulative incidences for chronic GVHD (cGVHD) at 2 years after HSCT were 35.2% (CI, 21.2-49.2%). Up to April 30, 2013, 12 patients had relapsed and 11 died from relapse, and 37 patients were still alive without disease recurrence. The relapse and NRM rates at 3 years were 25.3% (CI, 12.7-37.9%) and 18.0% (CI, 2.6-33.4%), respectively. The probalities of overall survival and leukemia free survival were 61.8% (CI, 46.0-77.6%) and 56.3% (CI, 38.1-74.5%) at 3 years, respectively. Patients transplanted during their hematological first complete remission (CR1) had a lower relapse rate (17.9% vs. 48.1%, P=0.03) compared with patients transplanted beyond CR1. The median overall survival for the 29 patients not receiving allo-HSCT during the study period was 145 days from diagnosis. This study showed that allo-HSCT could be a valuable treatment choice for MLL+ acute leukemia. Am. J. Hematol. 89:130-136, 2014. (c) 2013 Wiley Periodicals, Inc.

语种英语
WOS记录号WOS:000331334200003
项目编号81230013 ; 2011-4022-08 ; BZ0107 ; Z111107067311070 ; 11A72121174
资助机构Key Program of National Natural Science Foundation of China ; Scientific Research Foundation for Capital Medicine Development ; Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation for the Treatment of Hematological Diseases ; Beijing Municipal Science &amp ; Technology Commission ; Science and Technology Project of Guangzhou, China ; Leading Program of Clinical Faculty accredited by the Ministry of Health of China
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59547
专题北京大学第二临床医学院_血液科
北京大学药学院_药事管理与临床药学系
作者单位1.Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China
2.Nanfang Med Univ, Nanfang Hosp, Guangzhou, Guangdong, Peoples R China
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GB/T 7714
Wang Yu,Liu Qi-Fa,Qin Ya-Zhen,et al. Improved outcome with hematopoietic stem cell transplantation in a poor prognostic subgroup of patients with mixed-lineage-leukemia-rearranged acute leukemia: results from a prospective, multi-center study[J]. AMERICAN JOURNAL OF HEMATOLOGY,2014,89(2):130-136.
APA Wang Yu.,Liu Qi-Fa.,Qin Ya-Zhen.,Liu Dai-Hong.,Xu Lan-Ping.,...&Huang Xiao-Jun.(2014).Improved outcome with hematopoietic stem cell transplantation in a poor prognostic subgroup of patients with mixed-lineage-leukemia-rearranged acute leukemia: results from a prospective, multi-center study.AMERICAN JOURNAL OF HEMATOLOGY,89(2),130-136.
MLA Wang Yu,et al."Improved outcome with hematopoietic stem cell transplantation in a poor prognostic subgroup of patients with mixed-lineage-leukemia-rearranged acute leukemia: results from a prospective, multi-center study".AMERICAN JOURNAL OF HEMATOLOGY 89.2(2014):130-136.
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