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学科主题: 基础医学
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Multiple HLA class I and II associations in classical Hodgkin lymphoma and EBV status defined subgroups (Retracted article. See vol. 118, pg. 5211, 2011)
作者: Huang, Xin1,2; Kushekhar, Kushi1; Nolte, Ilja3; Kooistra, Wierd1; Visser, Lydia1; Bouwman, Ilby4; Kouprie, Niels4; Veenstra, Rianne1; van Imhoff, Gustaaf5; Olver, Bianca6; Houlston, Richard S.6; Poppema, Sibrand1; Diepstra, Arjan1; Hepkema, Bouke4; van den Berg, Anke1
刊名: BLOOD
发表日期: 2011-11-10
DOI: 10.1182/blood-2011-04-342998
卷: 118, 期:19, 页:5211-5217
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology
研究领域[WOS]: Hematology
关键词[WOS]: EPSTEIN-BARR-VIRUS ; NASOPHARYNGEAL CARCINOMA ; T-LYMPHOCYTES ; DISEASE ; ALLELES ; EPIDEMIOLOGY ; RECOGNITION ; GENES ; TOOL
英文摘要:

The pathogenesis of classical Hodgkin lymphoma (cHL) involves environmental and genetic factors. To explore the role of the human leukocyte antigen (HLA) genes, we performed a case-control genotyping study in 338 Dutch cHL patients and more than 5000 controls using a PCR-based sequence-specific oligonucleotide probe hybridization approach. HLA-A68 and HLA-DR11 (5) were significantly increased in the cHL patient population compared with the controls. Three class II associations were observed in the EBV- cHL population with an increase of HLA-DR15 (2) and a decrease of HLA-DR4 and HLA-DR7. Allele frequencies of HLA-A1, HLA-B37, and HLA-DR10 were significantly increased in the EBV+ cHL population; these alleles are in strong linkage disequilibrium and form a common haplotype in whites. The allele frequency of HLA-A2 was significantly decreased in the EBV- cHL population. Sequence-specific oligonucleotide probe analysis revealed significant differences between EBV+ and EBV- cHL patients for 19 probes that discriminate between HLA-A*01 and HLA-A*02. In conclusion, the HLA-A1 and HLA-A2 antigens and not specific single nucleotide variants shared by multiple alleles are responsible for the association with EBV+ cHL. Furthermore, several new protective and predisposing HLA class I and II associations for the EBV+, the EBV-, and the entire cHL population were identified. (Blood. 2011;118(19):5211-5217)

语种: 英语
所属项目编号: KWF:RUG2009-4313
项目资助者: University Medical Center Groningen ; Dutch Cancer Society
WOS记录号: WOS:000296867100022
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59548
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Univ Groningen, Dept Pathol & Med Biol, Univ Med Ctr Groningen, NL-9700 RB Groningen, Netherlands
2.Peking Univ, Dept Pathol, Hlth Sci Ctr, Beijing 100871, Peoples R China
3.Univ Groningen, Unit Genet Epidemiol & Bioinformat, Univ Med Ctr Groningen, Dept Epidemiol, NL-9700 RB Groningen, Netherlands
4.Univ Groningen, Dept Lab Med, Univ Med Ctr Groningen, NL-9700 RB Groningen, Netherlands
5.Univ Groningen, Dept Hematol, Univ Med Ctr Groningen, NL-9700 RB Groningen, Netherlands
6.Inst Canc Res, Sect Canc Genet, Sutton, Surrey, England

Recommended Citation:
Huang, Xin,Kushekhar, Kushi,Nolte, Ilja,et al. Multiple HLA class I and II associations in classical Hodgkin lymphoma and EBV status defined subgroups (Retracted article. See vol. 118, pg. 5211, 2011)[J]. BLOOD,2011,118(19):5211-5217.
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