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学科主题: 精神卫生
题名:
Prevalence, Distribution, and Impact of Mild Cognitive Impairment in Latin America, China, and India: A 10/66 Population-Based Study
作者: Sosa, Ana Luisa1; Albanese, Emiliano2; Stephan, Blossom C. M.3; Dewey, Michael4; Acosta, Daisy5; Ferri, Cleusa P.4; Guerra, Mariella6; Huang, Yueqin7; Jacob, K. S.8; Jimenez-Velazquez, Ivonne Z.9; Rodriguez, Juan J. Llibre10; Salas, Aquiles11; Williams, Joseph12; Acosta, Isaac1; Gonzalez-Viruet, Maribella13; Hernandez, Milagros A. Guerra14; Shuran, Li7; Prince, Martin J.4; Stewart, Robert4
刊名: PLOS MEDICINE
发表日期: 2012-02-01
DOI: 10.1371/journal.pmed.1001170
卷: 9, 期:2
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: ALZHEIMERS-DISEASE ; NEUROPSYCHIATRIC SYMPTOMS ; CARDIOVASCULAR HEALTH ; KUNGSHOLMEN PROJECT ; PREDICTIVE-VALIDITY ; GENERAL-POPULATION ; ELDERLY SUBJECTS ; CLINICAL ENTITY ; DEMENTIA ; COMMUNITY
英文摘要:

Background: Rapid demographic ageing is a growing public health issue in many low-and middle-income countries (LAMICs). Mild cognitive impairment (MCI) is a construct frequently used to define groups of people who may be at risk of developing dementia, crucial for targeting preventative interventions. However, little is known about the prevalence or impact of MCI in LAMIC settings.

Methods and Findings: Data were analysed from cross-sectional surveys established by the 10/66 Dementia Research Group and carried out in Cuba, Dominican Republic, Peru, Mexico, Venezuela, Puerto Rico, China, and India on 15,376 individuals aged 65+ without dementia. Standardised assessments of mental and physical health, and cognitive function were carried out including informant interviews. An algorithm was developed to define Mayo Clinic amnestic MCI (aMCI). Disability (12-item World Health Organization disability assessment schedule [WHODAS]) and informant-reported neuropsychiatric symptoms (neuropsychiatric inventory [NPI-Q]) were measured. After adjustment, aMCI was associated with disability, anxiety, apathy, and irritability (but not depression); between-country heterogeneity in these associations was only significant for disability. The crude prevalence of aMCI ranged from 0.8% in China to 4.3% in India. Country differences changed little (range 0.6%-4.6%) after standardization for age, gender, and education level. In pooled estimates, aMCI was modestly associated with male gender and fewer assets but was not associated with age or education. There was no significant between-country variation in these demographic associations.

Conclusions: An algorithm-derived diagnosis of aMCI showed few sociodemographic associations but was consistently associated with higher disability and neuropsychiatric symptoms in addition to showing substantial variation in prevalence across LAMIC populations. Longitudinal data are needed to confirm findings-in particular, to investigate the predictive validity of aMCI in these settings and risk/protective factors for progression to dementia; however, the large number affected has important implications in these rapidly ageing settings.

语种: 英语
所属项目编号: GR066133 ; IIRG - 04 - 1286
项目资助者: Wellcome Trust (UK) ; World Health Organization ; US Alzheimer&prime ; s Association ; Fondo Nacional de Ciencia Y Tecnologia ; Consejo de Desarrollo Cientifico Y Humanistico ; Universidad Central de Venezuela (Venezuela) ; NIHR Specialist Biomedical Research Centre for Mental Health at the South London ; Maudsley NHS Foundation Trust ; Institute of Psychiatry, King&prime ; s College London ; GlaxoSmithKline ; Novartis ; Lundbeck ; Pfizer ; Eisai ; ADI
WOS记录号: WOS:000301222600003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59553
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Univ Cambridge, Cambridge, England
2.Kings Coll London, Inst Psychiat, London, ON, Canada
3.UNPHU, Geriatr Sect, Dept Internal Med, Santo Domingo, Dominican Rep
4.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
5.Med Univ Havana, Havana, Cuba
6.Inst Community Hlth, Voluntary Hlth Serv, Madras, Tamil Nadu, India
7.Psy D Program Carlos Albizu Univ, San Juan, PR USA
8.Policlin Univ 27 Noviembre, Havana, Cuba
9.Univ Nacl Autonoma Mexico, Natl Inst Neurol & Neurosurg, Mexico City 04510, DF, Mexico
10.Natl Inst Aging, Lab Epidemiol Demog & Biometry, Bethesda, MD USA
11.Univ Peruana Cayetano Heredia, Inst Memoria & Desordenes Relacionados, Lima, Peru
12.Christian Med Coll & Hosp, Vellore, Tamil Nadu, India
13.Univ Puerto Rico, Sch Med, San Juan, PR 00936 USA
14.Cent Univ Venezuela, Caracas Univ Hosp, Fac Med, Dept Med, Caracas, Venezuela

Recommended Citation:
Sosa, Ana Luisa,Albanese, Emiliano,Stephan, Blossom C. M.,et al. Prevalence, Distribution, and Impact of Mild Cognitive Impairment in Latin America, China, and India: A 10/66 Population-Based Study[J]. PLOS MEDICINE,2012,9(2).
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