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学科主题: 基础医学
题名:
ADAMTS-7 promotes vascular smooth muscle cells proliferation in vitro and in vivo
作者: Zhang Lu1,2; Yu Fang1,2; Wang Li1,2; Zheng JinGang3; Du YaoYao1,2; Huang YaQian1,2; Liu Bo1,2; Wang Xian1,2; Kong Wei1,2
关键词: vascular smooth muscle cell ; ADAMTS-7 ; proliferation
刊名: SCIENCE CHINA-LIFE SCIENCES
发表日期: 2015-07-01
DOI: 10.1007/s11427-015-4843-2
卷: 58, 期:7, 页:674-681
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biology
研究领域[WOS]: Life Sciences & Biomedicine - Other Topics
关键词[WOS]: CORONARY-ARTERY-DISEASE ; GROWTH-FACTOR ; MIGRATION ; METALLOPROTEINASE ; MATRIX ; ATHEROSCLEROSIS ; INHIBITION ; INJURY ; CYCLE ; MATRIX-METALLOPROTEINASE-9
英文摘要:

Vascular smooth muscle cell (VSMC) proliferation and migration are pivotal for the pathogenesis of atherosclerosis and post-angioplasty restenosis. We have recently reported that a disintegrin and metalloproteinase with thrombospondin motifs-7 (ADAMTS-7), a novel metalloproteinase, contributes directly to neointima formation by mediating VSMC migration. However, whether ADAMTS-7 affects VSMC proliferation remains unclear. In this study, we found that luminal adenoviral delivery of ADAMTS-7 aggravated intimal hyperplasia 7 d after injury, paralleled by an increased percentage of PCNA-positive cells in both intima and media. In contrast, perivascular administration of ADAMTS-7 siRNA, but not scrambled siRNA to injured arteries attenuated intimal thickening at day 7, paralleled with reduced intimal VSMC replication, without alteration of VSMC proliferation in the media. In accordance, [H-3]-thymidine incorporation assay in primary cultured rat VSMCs revealed an enhanced replication rate (by 61%) upon ADAMTS-7 overexpression and retarded proliferation (by 23%) upon ADAMTS-7 siRNA administration. Our data demonstrates that ADAMTS-7 promotes VSMC proliferation both in vitro and in vivo. ADAMTS-7 may therefore serve as a novel therapeutic target for atherosclerosis and post-angioplasty restenosis.

语种: 英语
所属项目编号: 81220108004 ; 2012CB518002 ; 81070243 ; 81121061 ; 91339000 ; 81225002 ; B07001
项目资助者: International Cooperation and Exchanges of the National Natural Science Foundation of China ; National Basic Research Program of China ; National Natural Science Foundation of China ; National Science Fund for Distinguished Young Scholars ; Program of Introducing Talents of Discipline to Universities, Ministry of Education of China
WOS记录号: WOS:000359146700006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59560
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China
3.China Japan Friendship Hosp, Dept Cardiol, Beijing 100029, Peoples R China

Recommended Citation:
Zhang Lu,Yu Fang,Wang Li,et al. ADAMTS-7 promotes vascular smooth muscle cells proliferation in vitro and in vivo[J]. SCIENCE CHINA-LIFE SCIENCES,2015,58(7):674-681.
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