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学科主题: 基础医学
题名:
Subtype-specific beta-adrenoceptor signaling pathways in the heart and their potential clinical implications
作者: Xiao, RP; Zhu, WZ; Zheng, M; Chakir, K; Bond, R; Lakatta, EG; Cheng, HP
刊名: TRENDS IN PHARMACOLOGICAL SCIENCES
发表日期: 2004-07-01
DOI: 10.1016/j.tips.2004.05.007
卷: 25, 期:7, 页:358-365
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: RAT VENTRICULAR MYOCYTES ; ADRENERGIC-RECEPTOR KINASE ; CARDIAC G(S-ALPHA) OVEREXPRESSION ; HUMAN BETA(1)-ADRENERGIC RECEPTOR ; ACUTE MYOCARDIAL-INFARCTION ; FACTOR GENE-EXPRESSION ; TREATED GUINEA-PIGS ; FAILING HUMAN HEART ; BETA(2)-ADRENERGIC RECEPTOR ; G-PROTEIN
英文摘要:

beta-Adrenoceptor stimulation serves as the most powerful means to increase cardiac output in response to stress or exercise. However, sustained beta(2)-adrenoceptor stimulation promotes pathological cardiac remodeling such as myocyte hypertrophy and apoptosis, thus contributing to heart failure. Coexisting cardiac beta-adrenoceptor subtypes, mainly beta(1)-adrenoceptors and beta(2)-adrenoceptors, activate different signaling cascades with beta(1)-adrenoceptors coupling to G(s) and beta(2)-adrenoceptors coupling to G(s) and G(i) pathways. As a result, sustained beta(2)-adrenoceptor stimulation protects cardiomyocytes against apoptosis via a G(1)-phosphatidylinositol 3-kinaseprotein kinase B pathway, whereas chronic beta(1)-adrenoceptor stimulation induces myocyte hypertrophy and apoptosis by protein kinase A-independent activation of calmodullin kinase II signaling. These advances in our understanding of beta-adrenoceptor subtype signaling identify the mechanisms that underlie the beneficial effects of beta-adrenoceptor antagonists and delineate the rationale for combining beta(1)-adrenoceptor blockade with beta(2)-adrenoceptor activation as a potential therapy for heart failure.

语种: 英语
WOS记录号: WOS:000222791000008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59563
Appears in Collections:基础医学院_心血管所_期刊论文

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作者单位: 1.NIA, Cardiovasc Sci Lab, NIH, Baltimore, MD 21224 USA
2.Peking Univ, Minist Educ, Inst Cardiovasc Sci, Key Lab Mol & Cardiovasc Sci, Beijing, Peoples R China
3.Peking Univ, Minist Educ, Inst Mol Med, Key Lab Mol & Cardiovasc Sci, Beijing, Peoples R China
4.Univ Houston, Dept Pharmacol & Pharmaceut Sci, Houston, TX 77204 USA
5.Peking Univ, Coll Life Sci, Natl Lab Biomembrane & Membrane Biotechnol, Beijing, Peoples R China

Recommended Citation:
Xiao, RP,Zhu, WZ,Zheng, M,et al. Subtype-specific beta-adrenoceptor signaling pathways in the heart and their potential clinical implications[J]. TRENDS IN PHARMACOLOGICAL SCIENCES,2004,25(7):358-365.
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