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学科主题基础医学
Subtype-specific beta-adrenoceptor signaling pathways in the heart and their potential clinical implications
Xiao, RP; Zhu, WZ; Zheng, M; Chakir, K; Bond, R; Lakatta, EG; Cheng, HP
刊名TRENDS IN PHARMACOLOGICAL SCIENCES
2004-07-01
DOI10.1016/j.tips.2004.05.007
25期:7页:358-365
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]RAT VENTRICULAR MYOCYTES ; ADRENERGIC-RECEPTOR KINASE ; CARDIAC G(S-ALPHA) OVEREXPRESSION ; HUMAN BETA(1)-ADRENERGIC RECEPTOR ; ACUTE MYOCARDIAL-INFARCTION ; FACTOR GENE-EXPRESSION ; TREATED GUINEA-PIGS ; FAILING HUMAN HEART ; BETA(2)-ADRENERGIC RECEPTOR ; G-PROTEIN
英文摘要

beta-Adrenoceptor stimulation serves as the most powerful means to increase cardiac output in response to stress or exercise. However, sustained beta(2)-adrenoceptor stimulation promotes pathological cardiac remodeling such as myocyte hypertrophy and apoptosis, thus contributing to heart failure. Coexisting cardiac beta-adrenoceptor subtypes, mainly beta(1)-adrenoceptors and beta(2)-adrenoceptors, activate different signaling cascades with beta(1)-adrenoceptors coupling to G(s) and beta(2)-adrenoceptors coupling to G(s) and G(i) pathways. As a result, sustained beta(2)-adrenoceptor stimulation protects cardiomyocytes against apoptosis via a G(1)-phosphatidylinositol 3-kinaseprotein kinase B pathway, whereas chronic beta(1)-adrenoceptor stimulation induces myocyte hypertrophy and apoptosis by protein kinase A-independent activation of calmodullin kinase II signaling. These advances in our understanding of beta-adrenoceptor subtype signaling identify the mechanisms that underlie the beneficial effects of beta-adrenoceptor antagonists and delineate the rationale for combining beta(1)-adrenoceptor blockade with beta(2)-adrenoceptor activation as a potential therapy for heart failure.

语种英语
WOS记录号WOS:000222791000008
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被引频次:107[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59563
专题北京大学基础医学院_心血管所
作者单位1.NIA, Cardiovasc Sci Lab, NIH, Baltimore, MD 21224 USA
2.Peking Univ, Minist Educ, Inst Cardiovasc Sci, Key Lab Mol & Cardiovasc Sci, Beijing, Peoples R China
3.Peking Univ, Minist Educ, Inst Mol Med, Key Lab Mol & Cardiovasc Sci, Beijing, Peoples R China
4.Univ Houston, Dept Pharmacol & Pharmaceut Sci, Houston, TX 77204 USA
5.Peking Univ, Coll Life Sci, Natl Lab Biomembrane & Membrane Biotechnol, Beijing, Peoples R China
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GB/T 7714
Xiao, RP,Zhu, WZ,Zheng, M,et al. Subtype-specific beta-adrenoceptor signaling pathways in the heart and their potential clinical implications[J]. TRENDS IN PHARMACOLOGICAL SCIENCES,2004,25(7):358-365.
APA Xiao, RP.,Zhu, WZ.,Zheng, M.,Chakir, K.,Bond, R.,...&Cheng, HP.(2004).Subtype-specific beta-adrenoceptor signaling pathways in the heart and their potential clinical implications.TRENDS IN PHARMACOLOGICAL SCIENCES,25(7),358-365.
MLA Xiao, RP,et al."Subtype-specific beta-adrenoceptor signaling pathways in the heart and their potential clinical implications".TRENDS IN PHARMACOLOGICAL SCIENCES 25.7(2004):358-365.
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