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学科主题: 临床医学
题名:
Upregulated PD-1 Expression Is Associated with the Development of Systemic Lupus Erythematosus, but Not the PD-1.1 Allele of the PDCD1 Gene
作者: Jiao, Qingqing1; Liu, Cuiping2; Yang, Ziliang1; Ding, Qiang1; Wang, Miaomiao1; Li, Min1; Zhu, Tingting1; Qian, Hua3; Li, Wei3; Tu, Na1; Fang, Fumin1; Ye, Licai1; Zhao, Zuotao4; Qian, Qihong1
刊名: INTERNATIONAL JOURNAL OF GENOMICS
发表日期: 2014
DOI: 10.1155/2014/950903
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Genetics & Heredity
研究领域[WOS]: Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Genetics & Heredity
关键词[WOS]: REVISED CRITERIA ; AUTOIMMUNITY ; PATHWAY ; TOLERANCE ; SUSCEPTIBILITY ; CLASSIFICATION
英文摘要:

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with complicated genetic inheritance. Programmed death 1 (PD-1), a negative T cell regulator to maintain peripheral tolerance, induces negative signals to T cells during interaction with its ligands and is therefore a candidate gene in the development of SLE. In order to examine whether expression levels of PD-1 contribute to the pathogenesis of SLE, 30 patients with SLE and 30 controls were recruited and their PD-1 expression levels in peripheral blood mononuclear cells (PBMCs) were measured via flow cytometry and quantitative real-time-reverse transcription polymerase chain reaction (RT-PCR). Also, whether PD-1 expression levels are associated with the variant of the SNP rs36084323 and the SLE Disease Activity Index (SLEDAI) was studied in this work. The PD-1 expression levels of SLE patients were significantly increased compared with those of the healthy controls. The upregulated PD-1 expression levels in SLE patients were greatly associated with SLEDAI scores. No significant difference was found between PD-1 expression levels and SNP rs36084323. The results suggest that increased expression of PD-1 may correlate with the pathogenesis of SLE, upregulated PD-1 expression may be a biomarker for SLE diagnosis, and PD-1 inhibitor may be useful to SLE treatment.

语种: 英语
所属项目编号: KJXW2013002 ; 31170834 ; SYS201331
项目资助者: Suzhou Youth Science and Technology Project ; China Postdoctoral Science Foundation Project ; National Natural Science Foundation of China ; Science and Technology Project of Suzhou
WOS记录号: WOS:000335156100001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59564
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

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作者单位: 1.Soochow Univ, Affiliated Hosp 1, Dept Dermatol, Suzhou 215006, Peoples R China
2.Soochow Univ, Affiliated Hosp 1, Clin Immunol Lab, Suzhou 215007, Peoples R China
3.Soochow Univ, Affiliated Childrens Hosp, Dept Dermatol, Suzhou 215003, Peoples R China
4.Peking Univ, Dept Dermatol, Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Jiao, Qingqing,Liu, Cuiping,Yang, Ziliang,et al. Upregulated PD-1 Expression Is Associated with the Development of Systemic Lupus Erythematosus, but Not the PD-1.1 Allele of the PDCD1 Gene[J]. INTERNATIONAL JOURNAL OF GENOMICS,2014.
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