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学科主题: 临床医学
题名:
Prevention of relapse using DLI can increase survival following HLA-identical transplantation in patients with advanced-stage acute leukemia: a multi-center study
作者: Wang, Yu1; Liu, Dai-Hong1; Fan, Zhi-Ping2; Sun, Jing2; Wu, Xiao-Jin3; Ma, Xiao3; Xu, Lan-Ping1; Liu, Kai-Yan1; Liu, Qi-Fa2; Wu, De-Pei3; Huang, Xiao-Jun1
关键词: donor lymphocyte infusion ; relapse ; HLA matched ; Transplantation ; leukemia
刊名: CLINICAL TRANSPLANTATION
发表日期: 2012-07-01
DOI: 10.1111/j.1399-0012.2012.01626.x
卷: 26, 期:4, 页:635-643
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Surgery ; Transplantation
研究领域[WOS]: Surgery ; Transplantation
关键词[WOS]: STEM-CELL TRANSPLANTATION ; BONE-MARROW-TRANSPLANTATION ; DONOR LYMPHOCYTE INFUSION ; ACUTE MYELOID-LEUKEMIA ; PERIPHERAL-BLOOD LYMPHOCYTES ; RISK ACUTE-LEUKEMIA ; ACUTE GVHD ; THERAPY ; FEASIBILITY ; PROPHYLAXIS
英文摘要:

A total of 123 consecutive patients with advanced-stage, acute leukemia undergoing HSCT from HLA-identical sibling donors were analyzed. A G-CSF-primed DLI was planned within day 60 post-transplantation before hematologic relapse was diagnosed. Fifty of the 123 individuals received prophylactic DLI, and 73 individuals received no prophylactic treatment. The incidence of grades IIIV acute graft-versus-host disease (GVHD) was 17% for patients receiving DLI and 23% for patients not receiving DLI (p = 0.35). The incidence of chronic GVHD was 38% for patients receiving DLI and 17% for patients not receiving DLI (p = 0.021). The two-yr cumulative incidence of relapse was significantly lower in patients who received prophylactic DLI (46%) compared with patients who did not receive prophylactic DLI (66%) (p = 0.02). The three-yr probability of overall survival was higher in patients who received prophylactic DLI (36%) than in patients who did not receive prophylactic DLI (11%) (p = 0.001). The leukemia-free survival was also higher in patients who received prophylactic DLI (29%) than in patients who did not receive prophylactic DLI (9%) (p = 0.001). Our comparisons suggest that the prophylactic use of DLI can significantly increase survival of patients with advanced-stage, acute leukemia who receive HLA-identical sibling HSCT.

语种: 英语
所属项目编号: 30971292
项目资助者: National Natural Science Foundation of China ; National High-tech R&amp ; D Program of China (863 Program) ; Leading Program of Clinical Faculty
WOS记录号: WOS:000307344400035
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59576
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China
2.Nanfang Med Univ, Nanfang Hosp, Guangzhou, Guangdong, Peoples R China
3.Soochow Univ, Affiliated Hosp 1, Suzhou, Jiangsu, Peoples R China

Recommended Citation:
Wang, Yu,Liu, Dai-Hong,Fan, Zhi-Ping,et al. Prevention of relapse using DLI can increase survival following HLA-identical transplantation in patients with advanced-stage acute leukemia: a multi-center study[J]. CLINICAL TRANSPLANTATION,2012,26(4):635-643.
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