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Matrix metalloproteinase-8 levels and elastase activities in gingival crevicular fluid from chronic adult periodontitis patients
Chen, HY; Cox, SW; Eley, BM; Mantyla, P; Ronka, H; Sorsa, T
关键词gingival crevicular fluid periodontitis matrix metalloproteinase-8 collagenase elastase
刊名JOURNAL OF CLINICAL PERIODONTOLOGY
2000-05-01
27期:5页:366-369
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]CATHEPSIN-B/L-LIKE ; IV-LIKE ACTIVITIES ; COLLAGENASE ACTIVITY ; SULCULAR FLUID ; TRYPTASE-LIKE ; TRYPSIN-LIKE ; NEUTROPHIL ; INHIBITORS
英文摘要

Aim: To make an initial assessment of the periodontal diagnostic potential of immunoreactive matrix metalloproteinase-8 (MMP-8) in gingival crevicular fluid (GCF) by comparison with elastase activity which has previously been associated with disease severity and progression.

Methods: GCF was collected from molar and premolar sites of 16 chronic adult periodontitis patients before treatment and 13 of this group 2 weeks after scaling and root planing. Samples were analysed for MMP-8 by immunofluorometric assay and for elastase activity with a fluorogenic substrate.

Results: Mean patient clinical parameters and GCF enzyme totals both decreased significantly after treatment. Total MMP-8 levels and elastase activities generally correlated significantly with gingival and bleeding indices. For GCF concentrations, only MMP-8 showed a significant fall after treatment, and some significant correlations with clinical parameters. Amounts of the 2 enzymes correlated significantly with each other.

Conclusions: Similarities between MMP-8 and elastase probably reflect the fact that both enzymes are associated mainly with neutrophils: MMP-8 levels may have fallen more after treatment because the assay, unlike that for elastase, would most likely not have detected much enzyme bound to alpha(2)-macroglobulin. The immunoassay for MMP-8 is more specific and convenient than functional collagenase assays, and might be suitable for monitoring the periodontal condition.

语种英语
WOS记录号WOS:000086870800012
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被引频次:83[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59578
专题北京大学第三临床医学院_口腔科
作者单位1.Univ Helsinki, Inst Dent, Dept Periodontol, Helsinki, Finland
2.Oy Ale, Medix Biochem, Kauniainen, Finland
3.Guys Kings & St Thomas Dent Inst, Dept Periodontol, London SE5 9RW, England
4.Beijing Med Univ, Clin Sch 3, Dept Stomatol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Chen, HY,Cox, SW,Eley, BM,et al. Matrix metalloproteinase-8 levels and elastase activities in gingival crevicular fluid from chronic adult periodontitis patients[J]. JOURNAL OF CLINICAL PERIODONTOLOGY,2000,27(5):366-369.
APA Chen, HY,Cox, SW,Eley, BM,Mantyla, P,Ronka, H,&Sorsa, T.(2000).Matrix metalloproteinase-8 levels and elastase activities in gingival crevicular fluid from chronic adult periodontitis patients.JOURNAL OF CLINICAL PERIODONTOLOGY,27(5),366-369.
MLA Chen, HY,et al."Matrix metalloproteinase-8 levels and elastase activities in gingival crevicular fluid from chronic adult periodontitis patients".JOURNAL OF CLINICAL PERIODONTOLOGY 27.5(2000):366-369.
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