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Comparison of MRS and DWI in the diagnosis of prostate cancer based on sextant analysis
Li, Bo1; Cai, Wenchao2; Lv, Dongjiao1; Guo, Xuemei2; Zhang, Jue1,3; Wang, Xiaoying2,3; Fang, Jing1,3
关键词prostate cancer MR spectroscopic imaging Diffusion weighted imaging fisher linear discriminant analysis
刊名JOURNAL OF MAGNETIC RESONANCE IMAGING
2013
DOI10.1002/jmri.23809
37期:1页:194-200
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]RADICAL PROSTATECTOMY ; BIOPSY ; SUPPRESSION ; GRADE ; ROC
英文摘要

Purpose: To evaluate apparent diffusion coefficient (ADC) value, metabolic ratio ((Cho + Cr)/Cit) and the combination of the two in identifying prostate malignant regions. Materials and Methods: Fifty-six consecutive patients with prostate biopsy results were retrospectively recruited in this study. Transrectal ultrasound-guided (TRUS) systemic prostate biopsies were used as a standard of reference. Mean ADC value and mean metabolic ratio (MMR) were calculated within each benign sextant region or malignant region. The efficiency of these two indices in prostate cancer (PCa) diagnosis is estimated in Fisher linear discriminant analysis (FLDA). The area under the receiver operating characteristic (ROC) curve was used to evaluate the distinguishing capacity of mean ADC, MMR, and the combination of the two in differentiating between noncancerous and cancerous cases. Results: There were significant differences for mean ADC value and MMR between malignant and benign regions. Weights of mean ADC value obtained by FLDA were much higher than those of MMR. In differentiating malignant regions, both ADC alone and combined ADC and metabolic ratio performed significantly better than MMR alone. However, accuracy improvements were not significant by using combined ADC and MMR than ADC alone. Conclusion: DWI is more efficient than MR spectroscopic (MRS) in the detection of PCa in this study. Combined ADC and MMR performed significantly better than MMR alone in distinguishing malignant from benign region in prostate peripheral zone. J. Magn. Reson. Imaging 2013;37:194200. (c) 2012 Wiley Periodicals, Inc.

语种英语
WOS记录号WOS:000312720000021
资助机构Fundamental Research Funds for the Central Universities
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59584
专题北京大学第一临床医学院_放射治疗科
北京大学第一临床医学院_医学影像科
北京大学口腔医学院_牙周科
作者单位1.Peking Univ, Coll Engn, Beijing 100871, Peoples R China
2.Peking Univ, Hosp 1, Dept Radiol, Beijing 100871, Peoples R China
3.Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China
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GB/T 7714
Li, Bo,Cai, Wenchao,Lv, Dongjiao,et al. Comparison of MRS and DWI in the diagnosis of prostate cancer based on sextant analysis[J]. JOURNAL OF MAGNETIC RESONANCE IMAGING,2013,37(1):194-200.
APA Li, Bo.,Cai, Wenchao.,Lv, Dongjiao.,Guo, Xuemei.,Zhang, Jue.,...&Fang, Jing.(2013).Comparison of MRS and DWI in the diagnosis of prostate cancer based on sextant analysis.JOURNAL OF MAGNETIC RESONANCE IMAGING,37(1),194-200.
MLA Li, Bo,et al."Comparison of MRS and DWI in the diagnosis of prostate cancer based on sextant analysis".JOURNAL OF MAGNETIC RESONANCE IMAGING 37.1(2013):194-200.
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