北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 骨肿瘤科  > 期刊论文
学科主题: 临床医学
题名:
Outcome of Conservative Surgery for Giant Cell Tumor of the Sacrum
作者: Guo, Wei; Ji, Tao; Tang, Xiaodong; Yang, Yi
关键词: excision ; curettage ; giant cell tumor ; sacrum neoplasm ; function spare
刊名: SPINE
发表日期: 2009-05-01
DOI: 10.1097/BRS.0b013e31819d4127
卷: 34, 期:10, 页:1025-1031
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Orthopedics
研究领域[WOS]: Neurosciences & Neurology ; Orthopedics
关键词[WOS]: EN-BLOC RESECTION ; TERM-FOLLOW-UP ; TOTAL SACRECTOMY ; INITIAL-EXPERIENCE ; BLADDER FUNCTION ; BONE ; RECONSTRUCTION ; EXCISION ; METASTASES
英文摘要:

Study Design. Retrospective analysis. Objective. To estimate the clinical outcome of conservative surgery (intralesional curettage or partial excision) aided by effective intraoperative hemorrhage control in patients with giant cell tumors of the sacrum.

Summary of Background Data. Giant cell tumors of the sacrum present a challenging therapeutic problem. Wide resection is associated with higher morbidity and spinal instability. Whether conservative surgery aided by effective intraoperative hemorrhage control can achieve low recurrence rates remains uncertain.

Methods. The clinical records of 24 patients with an average age of 35 years who had undergone conservative surgery for sacral giant cell tumor between 1996 and 2005 were evaluated retrospectively. The disease onset, tumor size, operation records, complications, follow-up status, and functional outcome were analyzed.

Results. The mean duration of follow-up was 58 months (median, 50 months; range: 25-132 months). All the patients had a conservative procedure aided by intraoperative occlusion of the abdominal aorta. The mean estimated blood loss was 3217 mL. The mean length of the operation was 190 minutes. Seven (29.2%) patients developed recurrences. The mean time from the index surgical procedure to the first recurrence was 13 months (range: 8-31 months). The 5-year local recurrence-free survival rate was 69.6%. Seventeen (70.8%) patients retained normal urinary function and 16 (66.7%) patients preserved normal bowel function. No patients had urinary or bowel dysfunction when both S3 nerves were preserved. Ten (41.7%) patients had complications perioperatively or during the follow-up. Seven (29.2%) patients had wound complications.

Conclusion. Considering the acceptable local recurrence rate, conservative surgery aided by effective control of intraoperative hemorrhage should be considered as an alternative procedure for patients with giant cell tumors of the sacrum. The advantages include lower morbidity, reduced neurologic deficits, speed and ease of the surgical procedure, reduced blood loss, preservation of spinal and pelvic continuity, and a low recurrence rate.

语种: 英语
WOS记录号: WOS:000265677900007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59585
Appears in Collections:北京大学第二临床医学院_骨肿瘤科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Peoples Hosp, Musculoskeletal Tumor Ctr, Beijing 100083, Peoples R China

Recommended Citation:
Guo, Wei,Ji, Tao,Tang, Xiaodong,et al. Outcome of Conservative Surgery for Giant Cell Tumor of the Sacrum[J]. SPINE,2009,34(10):1025-1031.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Guo, Wei]'s Articles
[Ji, Tao]'s Articles
[Tang, Xiaodong]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Guo, Wei]‘s Articles
[Ji, Tao]‘s Articles
[Tang, Xiaodong]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace