IR@PKUHSC  > 北京大学基础医学院  > 病理学系
学科主题基础医学
Avian influenza receptor expression in H5N1-infected and noninfected human tissues
Yao, Lu1; Korteweg, Christine1; Hsueh, Wei3; Go, Jiang1,2
关键词sialic acid human influenza virus receptors lectin
刊名FASEB JOURNAL
2008-03-01
DOI10.1096/fj.06-7880com
22期:3页:733-740
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biology ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology
关键词[WOS]HUMAN AIRWAY EPITHELIUM ; LOWER RESPIRATORY-TRACT ; A H5N1 INFECTION ; SIALIC-ACID ; BINDING SPECIFICITY ; VIRUS ; HEMAGGLUTININ ; CELL ; HOST ; TRANSMISSION
英文摘要

Avian and human influenza viruses preferentially bind to alpha-2,3-linked and alpha-2,6-linked sialic acids, respectively. Until today, the distributions of these two receptor types had never been investigated in H5N1-infected human tissue samples. Here, the expression of avian (AIV-Rs) and human influenza receptors (HuIV-Rs) is studied in various organs (upper and lower respiratory tracts, brain, placenta, liver, kidney, heart, intestines, and spleen) of two H5N1 cases and 14 control cases. Histochemical stains using biotinylated Maackia amurensis lectin 11 and Sambucus nigra agglutinin were performed to localize AIV-Rs and HuIV-Rs, respectively. Immunohistochemical stainings were performed to identify the receptor-bearing cells. AIV-Rs were detected on type II pneumocytes; a limited number of epithelial cells of the upper respiratory tract; and the bronchi, bronchioli, and trachea; as well as on Kupffer cells, glomerular cells, splenic T cells, and neurons in the brain and intestines. HuIV-Rs were abundantly present in the respiratory tract and lungs. They were also detected on Hofbauer cells, glomerular cells, splenic B cells, and in the liver. Moreover, endothelial cells of all organs examined expressed both receptor types. In conclusion, the distribution pattern of AIV-Rs is partially inconsistent with the pattern of infected cells as detected in previous studies, which suggests there may be other receptors or mechanisms involved in H5N1 infection. In addition, the diffuse presence of receptors on endothelial cells may account for the multiple organ involvement in H5N1 influenza. Finally, the relative lack of AIV-Rs in the upper airway may be a one of the factors preventing efficient human-to-human transmission of H5N1 influenza.

语种英语
WOS记录号WOS:000254143700012
Citation statistics
Cited Times:87[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59591
Collection北京大学基础医学院_病理学系
作者单位1.Peking Univ, Ctr Infect Dis, Beijing 100871, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Pathol, Beijing 100083, Peoples R China
3.Northwestern Univ, Feinberg Sch Med, Dept Pathol, Chicago, IL USA
Recommended Citation
GB/T 7714
Yao, Lu,Korteweg, Christine,Hsueh, Wei,et al. Avian influenza receptor expression in H5N1-infected and noninfected human tissues[J]. FASEB JOURNAL,2008,22(3):733-740.
APA Yao, Lu,Korteweg, Christine,Hsueh, Wei,&Go, Jiang.(2008).Avian influenza receptor expression in H5N1-infected and noninfected human tissues.FASEB JOURNAL,22(3),733-740.
MLA Yao, Lu,et al."Avian influenza receptor expression in H5N1-infected and noninfected human tissues".FASEB JOURNAL 22.3(2008):733-740.
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