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The Diterpenes Ovoideal A-G from Tirpitzia ovoidea
Su, Dan; Yang, Xue-Yan; Feng, Xu; Shang, Ming-Ying; Cai, Shao-Qing
关键词Tirpitzia ovoidea Linaceae diterpene cytotoxic activity
刊名MOLECULES
2014-11-01
DOI10.3390/molecules191118966
19期:11页:18966-18979
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]CISTUS-CRETICUS ; RESIN LADANO ; METABOLITES ; CHEMISTRY ; OXIDES ; ROOTS ; NMR
英文摘要

Seven new diterpenes, named ovoideal A (1), B (2), C (3), D (4), E (5), F (6) and G (7), have been isolated along with eleven known diterpenes 8-18 from the petroleum ether soluble fraction of an ethanol extract of the aerial parts of Tirpitzia ovoidea. The structures of the new compounds were elucidated primarily by 1D and 2D NMR spectroscopy, as well as by the HR-ESI-MS spectrometry. All compounds were isolated from the Linaceae family for the first time. The in vitro cytotoxic activity of compounds 1, 3-5, 8-18 was evaluated against the Hela, HepG2 and K562 cell lines. Among them, compounds 3, 9, 11, 12, 13, 14, 15, 17, 18 showed moderate inhibitory activities.

语种英语
WOS记录号WOS:000345564300111
项目编号2013ZX09103002-006 ; 2013ZX09508104
资助机构National Key Technology R&amp ; D Program "New Drug Innovation" of China
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59595
专题北京大学药学院_天然药物学系
作者单位Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Su, Dan,Yang, Xue-Yan,Feng, Xu,et al. The Diterpenes Ovoideal A-G from Tirpitzia ovoidea[J]. MOLECULES,2014,19(11):18966-18979.
APA Su, Dan,Yang, Xue-Yan,Feng, Xu,Shang, Ming-Ying,&Cai, Shao-Qing.(2014).The Diterpenes Ovoideal A-G from Tirpitzia ovoidea.MOLECULES,19(11),18966-18979.
MLA Su, Dan,et al."The Diterpenes Ovoideal A-G from Tirpitzia ovoidea".MOLECULES 19.11(2014):18966-18979.
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