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Light Deprivation Induces Depression-Like Behavior and Suppresses Neurogenesis in Diurnal Mongolian Gerbil (Meriones unguiculatus)
Lau, Benson Wui-Man1; Ren, Chaoran2; Yang, Jian1; Yan, Sylvia W. L.1; Chang, Raymond Chuen-Chung1,3; Pu, Mingliang2; So, Kwok-Fai1,4,5
关键词Seasonal affective disorder (SAD) Neurogenesis Light deprivation Hippocampus Subventricular zone Mongolian gerbil Diurnal
刊名CELL TRANSPLANTATION
2011
DOI10.3727/096368910X539065
20期:6页:871-881
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell & Tissue Engineering ; Medicine, Research & Experimental ; Transplantation
资助者National Science foundation of China ; Ministry of Science and Technology of China ; NSFC/RGC ; Fundamental Research Funds for the Central Universities ; National Basic Research Program of China (973 Program) ; National Science foundation of China ; Ministry of Science and Technology of China ; NSFC/RGC ; Fundamental Research Funds for the Central Universities ; National Basic Research Program of China (973 Program)
研究领域[WOS]Cell Biology ; Research & Experimental Medicine ; Transplantation
关键词[WOS]SEASONAL AFFECTIVE-DISORDER ; FORCED SWIMMING TEST ; ADULT HIPPOCAMPAL NEUROGENESIS ; HYPERSOMNIC WINTER DEPRESSION ; ANXIETY-LIKE BEHAVIORS ; TAIL SUSPENSION TEST ; CIRCADIAN TEMPERATURE ; CELL-PROLIFERATION ; CONSTANT ROUTINE ; MOOD DISORDERS
英文摘要

Recent evidence suggests that adult neurogenesis contributes to the pathophysiology of different psychiatric disorders, including depressive disorder, anxiety disorder, and schizophrenia. Seasonal affective disorder (SAD) is a specific form of recurrent depressive disorder that can be induced by shortened light period. It is unclear yet whether neurogenesis is affected in SAD or under altered light/dark cycle. The present study aims at examining whether neurogenesis and dendritic growth of immature neurons are affected in Mongolian gerbils, a mainly diurnal rodent, under light deprivation. Animals were divided into two groups: the control (kept in 12 h light: 12 h dark) and the light-deprived groups (kept in 24 h dark). Depression-like behaviors and neurogenesis were assessed after 2 weeks. Compared with the control group, light-deprived gerbils showed increased immobile time in the tail suspension test and forced swimming test, which indicates induction of depression-like behavior. Cell proliferation in both the hippocampal and subventricular zone were significantly decreased in the light-deprived group, which also showed a decreased neuronal differentiation. Dendritic maturation of immature neurons was suppressed by light deprivation, which is revealed by doublecortin staining and Sholl analysis. The results revealed that the light/dark cycle exerts impacts on neurogenesis and maturation of new neurons. Additionally, the current experiment may offer a model for exploring the relationship among daylight exposure, circadian cycles, depressive behavior, and the underlying mechanisms.

语种英语
所属项目编号663031 ; 2007AA02Z146 ; 2009CB320900 ; N_HKU750/08 ; 21609101 ; 2011CB707501
资助者National Science foundation of China ; Ministry of Science and Technology of China ; NSFC/RGC ; Fundamental Research Funds for the Central Universities ; National Basic Research Program of China (973 Program) ; National Science foundation of China ; Ministry of Science and Technology of China ; NSFC/RGC ; Fundamental Research Funds for the Central Universities ; National Basic Research Program of China (973 Program)
WOS记录号WOS:000294095600007
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59597
专题基础医学院
作者单位1.Univ Hong Kong, Dept Anat, Li Ka Shing Fac Med, State Key Lab Brain & Cognit Sci,Res Ctr Heart Br, Pokfulam, Hong Kong, Peoples R China
2.Peking Univ, Dept Anat & Embryol, Sch Basic Med Sci, Key Lab Machine Percept, Beijing 100871, Peoples R China
3.Univ Hong Kong, Lab Neurodegenerat Dis, Dept Anat, LKS Fac Med, Pokfulam, Hong Kong, Peoples R China
4.Jinan Univ, Joint Lab Brain Funct & Hlth BFAH, Guangzhou, Guangdong, Peoples R China
5.Univ Hong Kong, Guangzhou, Guangdong, Peoples R China
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Lau, Benson Wui-Man,Ren, Chaoran,Yang, Jian,et al. Light Deprivation Induces Depression-Like Behavior and Suppresses Neurogenesis in Diurnal Mongolian Gerbil (Meriones unguiculatus)[J]. CELL TRANSPLANTATION,2011,20(6):871-881.
APA Lau, Benson Wui-Man.,Ren, Chaoran.,Yang, Jian.,Yan, Sylvia W. L..,Chang, Raymond Chuen-Chung.,...&So, Kwok-Fai.(2011).Light Deprivation Induces Depression-Like Behavior and Suppresses Neurogenesis in Diurnal Mongolian Gerbil (Meriones unguiculatus).CELL TRANSPLANTATION,20(6),871-881.
MLA Lau, Benson Wui-Man,et al."Light Deprivation Induces Depression-Like Behavior and Suppresses Neurogenesis in Diurnal Mongolian Gerbil (Meriones unguiculatus)".CELL TRANSPLANTATION 20.6(2011):871-881.
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