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Is the C677T polymorphism in methylenetetrahydrofolate reductase gene or plasma homocysteine a risk factor for diabetic peripheral neuropathy in Chinese individuals?
Wang, Hongli; Fan, Dongsheng; Hong, Tianpei
关键词homocysteine methylenetetrahydrofolate reductase type 2 diabetes mellitus diabetic peripheral neuropathy neural regeneration
刊名NEURAL REGENERATION RESEARCH
2012-10-25
DOI10.3969/j.issn.1673-5374.2012.30.009
7期:30页:2384-2391
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Neurosciences
资助者Natural Science Foundation of Beijing ; Natural Science Foundation of Beijing
研究领域[WOS]Cell Biology ; Neurosciences & Neurology
关键词[WOS]MTHFR C677T ; DIAGNOSTIC-CRITERIA ; ASSOCIATION ; NEPHROPATHY ; MELLITUS ; POLYNEUROPATHY ; PATHOGENESIS ; DYSFUNCTION ; RETINOPATHY ; VARIANT
英文摘要

The present study enrolled 251 diabetic patients, including 101 with neuropathy and 150 without neuropathy. Of the 150 patients, 100 had no complications, such as retinopathy, nephropathy, or neuropathy. Polymerase chain reaction-restriction fragment length polymorphism analysis was used to identify methylenetetrahydrofolate reductase gene variants. Plasma homocysteine levels were also measured. Homocysteine levels and the frequency of hyperhomocysteinemia were significantly higher in patients with diabetic peripheral neuropathy compared with diabetic patients without-neuropathy (P < 0.05). In logistic regression analysis with neuropathy as the dependent variable, the frequency of C677T in methylenetetrahydrofolate reductase was significantly higher in patients with diabetic peripheral neuropathy compared with patients without diabetic complications. Homocysteine levels were significantly higher in patients with diabetic peripheral neuropathy carrying the 677T allele and low folic acid levels. In conclusion, hyperhomocysteinemia is an independent risk factor for diabetic neuropathy in Chinese patients with diabetes. The C677T polymorphism in methylenetetrahydrofolate reductase and low folic acid levels may be risk factors for diabetic peripheral neuropathy in Chinese patients with diabetes.

语种英语
所属项目编号7102161
资助者Natural Science Foundation of Beijing ; Natural Science Foundation of Beijing
WOS记录号WOS:000310828000009
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59598
专题北京大学第三临床医学院_神经内科
作者单位Peking Univ, Dept Neurol, Hosp 3, Beijing 100191, Peoples R China
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GB/T 7714
Wang, Hongli,Fan, Dongsheng,Hong, Tianpei. Is the C677T polymorphism in methylenetetrahydrofolate reductase gene or plasma homocysteine a risk factor for diabetic peripheral neuropathy in Chinese individuals?[J]. NEURAL REGENERATION RESEARCH,2012,7(30):2384-2391.
APA Wang, Hongli,Fan, Dongsheng,&Hong, Tianpei.(2012).Is the C677T polymorphism in methylenetetrahydrofolate reductase gene or plasma homocysteine a risk factor for diabetic peripheral neuropathy in Chinese individuals?.NEURAL REGENERATION RESEARCH,7(30),2384-2391.
MLA Wang, Hongli,et al."Is the C677T polymorphism in methylenetetrahydrofolate reductase gene or plasma homocysteine a risk factor for diabetic peripheral neuropathy in Chinese individuals?".NEURAL REGENERATION RESEARCH 7.30(2012):2384-2391.
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