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学科主题基础医学
Synthesis and Anti-tumor Activity of Novel 2-Amino-1,3,4-thiadiazole Derivativers
Zou Xiajuan1; Liu Ying2; Liu Zhengming2; Gao Junwei3; Song Qianliu3; Pan Yan3; Zhang Jianchao3; Li Xuejun3; Lai Luhua2
关键词2-amino-1,3,4-thiadiazole synthesis anti-tumor activity lewis lung carcinoma mouse
刊名CHINESE JOURNAL OF ORGANIC CHEMISTRY
2011-11-01
31期:11页:1923-1929
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]PHASE-II TRIAL ; N-SUBSTITUTED 2-AMINO-5-(2,4-DIHYDROXYPHENYL)-1,3,4-THIADIAZOLES ; CARBONIC-ANHYDRASE INHIBITORS ; IN-VITRO ; AMINOTHIADIAZOLE ; CANCER ; 2-ACYLAMINO-1,3,4-THIADIAZOLES ; AGENTS ; TUMORS ; CELLS
英文摘要

A series of novel N-1-(5-substituted-1,3,4-thiadiazole-2-yl)-N-3-substituted phenyl-urea derivatives have been synthesized and evaluated for their anti-tumor activity. The effect of the title compounds on tumor metastasis was analyzed by Lewis-lung-carcinoma model. The bioassay showed that some title compounds dramatically reduced the numbers of lung metastasis and depressed the primary tumor growth. The structures of compounds were identified from the elemental analysis, IR and H-1 NMR.

语种中文
WOS记录号WOS:000297908100025
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59600
专题北京大学基础医学院
北京大学医学信息学中心
作者单位1.Peking Univ, Prote Lab, Med & Healthy Analyt Ctr, Hlth Sci Ctr, Beijing 100191, Peoples R China
2.Peking Univ, State Key Lab Struct Chem Studies Stable & Unstab, Inst Phys Chem, Coll Chem & Mol Engn, Beijing 100871, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Hlth Sci Ctr, Beijing 100191, Peoples R China
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GB/T 7714
Zou Xiajuan,Liu Ying,Liu Zhengming,et al. Synthesis and Anti-tumor Activity of Novel 2-Amino-1,3,4-thiadiazole Derivativers[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2011,31(11):1923-1929.
APA Zou Xiajuan.,Liu Ying.,Liu Zhengming.,Gao Junwei.,Song Qianliu.,...&Lai Luhua.(2011).Synthesis and Anti-tumor Activity of Novel 2-Amino-1,3,4-thiadiazole Derivativers.CHINESE JOURNAL OF ORGANIC CHEMISTRY,31(11),1923-1929.
MLA Zou Xiajuan,et al."Synthesis and Anti-tumor Activity of Novel 2-Amino-1,3,4-thiadiazole Derivativers".CHINESE JOURNAL OF ORGANIC CHEMISTRY 31.11(2011):1923-1929.
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