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学科主题: 基础医学
题名:
Synthesis and Anti-tumor Activity of Novel 2-Amino-1,3,4-thiadiazole Derivativers
作者: Zou Xiajuan1; Liu Ying2; Liu Zhengming2; Gao Junwei3; Song Qianliu3; Pan Yan3; Zhang Jianchao3; Li Xuejun3; Lai Luhua2
关键词: 2-amino-1,3,4-thiadiazole ; synthesis ; anti-tumor activity ; lewis lung carcinoma mouse
刊名: CHINESE JOURNAL OF ORGANIC CHEMISTRY
发表日期: 2011-11-01
卷: 31, 期:11, 页:1923-1929
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: PHASE-II TRIAL ; N-SUBSTITUTED 2-AMINO-5-(2,4-DIHYDROXYPHENYL)-1,3,4-THIADIAZOLES ; CARBONIC-ANHYDRASE INHIBITORS ; IN-VITRO ; AMINOTHIADIAZOLE ; CANCER ; 2-ACYLAMINO-1,3,4-THIADIAZOLES ; AGENTS ; TUMORS ; CELLS
英文摘要:

A series of novel N-1-(5-substituted-1,3,4-thiadiazole-2-yl)-N-3-substituted phenyl-urea derivatives have been synthesized and evaluated for their anti-tumor activity. The effect of the title compounds on tumor metastasis was analyzed by Lewis-lung-carcinoma model. The bioassay showed that some title compounds dramatically reduced the numbers of lung metastasis and depressed the primary tumor growth. The structures of compounds were identified from the elemental analysis, IR and H-1 NMR.

语种: 中文
WOS记录号: WOS:000297908100025
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59600
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Peking Univ, Prote Lab, Med & Healthy Analyt Ctr, Hlth Sci Ctr, Beijing 100191, Peoples R China
2.Peking Univ, State Key Lab Struct Chem Studies Stable & Unstab, Inst Phys Chem, Coll Chem & Mol Engn, Beijing 100871, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Hlth Sci Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Zou Xiajuan,Liu Ying,Liu Zhengming,et al. Synthesis and Anti-tumor Activity of Novel 2-Amino-1,3,4-thiadiazole Derivativers[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2011,31(11):1923-1929.
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