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学科主题: 临床医学
题名:
Haploidentical Hematopoietic Stem Cell Transplantation without In Vitro T Cell Depletion for the Treatment of Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia
作者: Chen, Huan; Liu, Kai-yan; Xu, Lan-ping; Chen, Yu-hong; Han, Wei; Zhang, Xiao-hui; Wang, Yu; Qin, Ya-zhen; Liu, Yan-rong; Huang, Xiao-jun
关键词: Haploidentical ; Hematopoietic stem cell transplantation ; Philadelphia chromosome ; Acute lymphoblastic leukemia ; Imatinib resistance
刊名: BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
发表日期: 2015-06-01
DOI: 10.1016/j.bbmt.2015.02.009
卷: 21, 期:6, 页:1110-1116
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Immunology ; Transplantation
研究领域[WOS]: Hematology ; Immunology ; Transplantation
关键词[WOS]: VERSUS-HOST-DISEASE ; TERM-FOLLOW-UP ; TOTAL-BODY IRRADIATION ; ACUTE MYELOID-LEUKEMIA ; ADULT PATIENTS ; MARROW-TRANSPLANTATION ; IMATINIB ; CHEMOTHERAPY ; SURVIVAL ; COMBINATION
英文摘要:

The role of haploidentical related allogeneic hematopoietic stem cell transplantation (allo-HSCT) in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) is not clear. We aimed to investigate the long-term survival of Ph+ ALL patients who underwent haploidentical donor (HID)-HSCT and to analyze the factors influencing relapse and survival after allo-HSCT. The study population included Ph+ ALL patients who underwent haploidentical related allo-HSCT. Additionally, Ph+ ALL patients who underwent HLA-matched related donor (MRD) transplants during the same period were included to compare outcomes.,BCR-ABL transcript levels were analyzed by using real-time quantitative reverse transcription PCR. Clinical data from 139 Ph+ ALL patients who received allo-HSCT in our center were analyzed. Of these patients, 101 received HID transplants and 38 received MRD transplants. At a median follow-up of 36 months, 5-year disease-free survival (DFS) and overall survival (OS) rates in the HID transplant group were 65.8% and 74.0%, respectively. The 5-year cumulative incidence of relapse (CIR) and nonrelapse mortality (NRM) rates for the HID transplant group were 20.3% and 15.6%, respectively. In addition, there were no differences in OS, DFS, CIR, and NRM between the HID and MRD groups. Multivariate analysis showed that imatinib resistance was a significant factor influencing DFS and CIR in HID transplant patients. Haploidentical HSCT for the treatment of Ph+ ALL achieves promising long-term survival, which is comparable with that of HLA-MRD HSCT. Imatinib resistance is a negative predictor of relapse and DFS after allo-HSCT. (C) 2015 Published by Elsevier Inc. on behalf of American Society for Blood and Marrow Transplantation.

语种: 英语
所属项目编号: 81230013 ; Z141100000214011 ; 81170483
项目资助者: Natural Science Foundation of China ; Beijing Science &amp ; Technology Program ; Nature Science Foundation of China
WOS记录号: WOS:000354667900019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59601
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: Peking Univ, Inst Hematol, Peoples Hosp, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing 100044, Peoples R China

Recommended Citation:
Chen, Huan,Liu, Kai-yan,Xu, Lan-ping,et al. Haploidentical Hematopoietic Stem Cell Transplantation without In Vitro T Cell Depletion for the Treatment of Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,2015,21(6):1110-1116.
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