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学科主题: 临床医学
题名:
Antibody to Hepatitis B Core Antigen Levels in the Natural History of Chronic Hepatitis B A Prospective Observational Study
作者: Jia, Wei1,2; Song, Liu-Wei3; Fang, Yu-Qing1,2; Wu, Xiao-Feng4; Liu, Dan-Yang4; Xu, Chun4; Wang, Xiao-Mei4; Wang, Wen4; Lv, Dong-Xia4; Li, Jun1,2; Deng, Yong-Qiong1,2; Wang, Yan1,2; Huo, Na1,2; Yu, Min1,2; Xi, Hong-Li1,2; Liu, Dan1,2; Zhou, Yi-Xing1,2; Wang, Gui-Qiang1,2; Xia, Ning-Shao3; Zhang, Ming-Xiang4
刊名: MEDICINE
发表日期: 2014-12-01
DOI: 10.1097/MD.0000000000000322
卷: 93, 期:29
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: VIRUS INFECTION ; POSITIVE PATIENTS ; SEROCONVERSION ; PERSPECTIVE ; HBSAG ; HELP ; HBC
英文摘要:

Previous studies have revealed antibody to hepatitis B core antigen (anti-HBc) levels as a predictor of treatment response in hepatitis B early antigen (HBeAg)-positive chronic hepatitis B (CHB) patients in both interferon and nucleos(t) ide analog therapy cohorts. However, there is no information about anti-HBc levels in the natural history of CHB.

This study aimed to define anti-HBc levels of different phases in the natural history of CHB.

Two hundred eleven treatment-naive CHB patients were included in the study. They were classified into 4 phases: immune tolerance (IT) phase (n = 39), immune clearance (IC) phase (n = 48), low or no-replicative (LR) phase (n = 55), andHBeAg-negative hepatitis(ENH, n = 69). Fifty patients who were HBsAg negative and anti-HBc positive were also recruited as past HBV infection (PBI) control group. Anti-HBc levels were measured by a newly developed double-sandwich immunoassay. Correlation of anti-HBc levels with alanine aminotransferase (ALT) and other HBV-related markers within each phase was performed.

Serum anti-HBc levels were statistically significant between patients in different phases of CHB (P < 0.001). The median anti-HBc levels were: IT (3.17 log(10) IU/mL), IC (4.39 log(10) IU/mL), LR (3.29 log(10) IU/mL), ENH (4.12 log(10) IU/mL), and PBI (0.61 log(10) IU/mL). There existed a strong correlation in IC (r = 0.489, P< 0.001), a poor correlation in ENH (r = 0.275, P = 0.042), and no correlation in patients with ALT reached 5 times upper limit of normal (r = 0.120, P = 0.616).

Anti-HBc levels show significant differences during the natural course of CHB. These results may provide some potentially useful insights into hepatitis B pathogenesis and immune activation against hepatitis B virus.

语种: 英语
项目资助者: key disciplines of Beijing ; key clinical medical disciplines of China
WOS记录号: WOS:000346985700025
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59609
Appears in Collections:北京大学第一临床医学院_感染疾病科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Ctr Liver Dis, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Dept Infect Dis, Beijing 100034, Peoples R China
3.Xiamen UniversityFujian, Natl Inst Diagnost & Vaccine Dev Infect Dis, State Key Lab Mol Vaccinol & Mol Diagnost, Xiamen, Peoples R China
4.Sixth Hosp ShenyangLiaoning, Dept Infect Dis, Shenyang, Peoples R China

Recommended Citation:
Jia, Wei,Song, Liu-Wei,Fang, Yu-Qing,et al. Antibody to Hepatitis B Core Antigen Levels in the Natural History of Chronic Hepatitis B A Prospective Observational Study[J]. MEDICINE,2014,93(29).
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