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Apoptosis and KI 67 index correlate with preoperative chemotherapy efficacy and better predict the survival of gastric cancer patients with combined therapy
Wu, Aiwen1; Jia, Yongning1,2; Dong, Bin3; Tang, Lei4; Liu, Yiqiang4; Du, Hong1; Yuan, Peng1; Dong, Peide2; Ji, Jiafu1
关键词Apoptosis index Gastrectomy Gastric cancer Ki67 index Neoadjuvant chemotherapy
刊名CANCER CHEMOTHERAPY AND PHARMACOLOGY
2014-05-01
DOI10.1007/s00280-014-2410-3
73期:5页:885-893
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Pharmacology & Pharmacy
研究领域[WOS]Oncology ; Pharmacology & Pharmacy
关键词[WOS]ESTROGEN-RECEPTOR STATUS ; CARCINOMA ; INDUCTION ; CELLS
英文摘要

The correlation of apoptotic and proliferation index with preoperative chemotherapy efficacy was investigated. Their prognostic value was also explored.

167 patients were enrolled, curative gastrectomy and D2 lymphadenectomy were performed, and a total of 12 cycles of perioperative mFOLFOX7 chemotherapy was recommended. Apoptosis index (AI) and Ki67 index (KI) in surgical specimens were detected.

Apoptosis index, KI and AI/KI were significantly different between patients received perioperative chemotherapy and surgery (CS group, n = 84) and those who received only surgery and postoperative chemotherapy (S group, n = 83). In the CS group, number of patients who received 2, 4, 6 cycles of preoperative chemotherapy were, respectively, 28, 53 and 3. AI, KI and AI/KI were closely related to pathological response. Cutoff value of AI and AI/KI for response separated CS group patients into two subgroups with significant different prognosis and picked up more potential responders than pathological evaluation, especially in pathological response evaluation grade 1a-b.

Apoptosis index, KI and AI/KI are significantly related to chemotherapy efficacy and prognosis of gastric cancer patients who received perioperative chemotherapy and radical gastrectomy. They could be used in combination with pathological response evaluation to distinguish more potential responders.

语种英语
WOS记录号WOS:000335391500002
项目编号81071983 ; 2007B-057
资助机构Natural Science Foundation of China ; Beijing Municipal Science and Technology Commission NOVA program
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59614
专题北京大学临床肿瘤学院_中心实验室
北京大学临床肿瘤学院_胃肠肿瘤中心一病区
北京大学临床肿瘤学院_医学影像科
北京大学临床肿瘤学院_病理科
北京大学临床肿瘤学院_标本库
作者单位1.Peking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ,Dept Gastrointestinal Surg, Beijing 100142, Peoples R China
2.Inner Mongolia Med Univ, Affiliated Hosp, Dept Gastrointestinal Surg, Hohhot 010050, Inner Mongolia, Peoples R China
3.Peking Univ, Canc Hosp & Inst, Dept Pathol, Beijing 100142, Peoples R China
4.Peking Univ, Canc Hosp & Inst, Dept Radiol, Beijing 100142, Peoples R China
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GB/T 7714
Wu, Aiwen,Jia, Yongning,Dong, Bin,et al. Apoptosis and KI 67 index correlate with preoperative chemotherapy efficacy and better predict the survival of gastric cancer patients with combined therapy[J]. CANCER CHEMOTHERAPY AND PHARMACOLOGY,2014,73(5):885-893.
APA Wu, Aiwen.,Jia, Yongning.,Dong, Bin.,Tang, Lei.,Liu, Yiqiang.,...&Ji, Jiafu.(2014).Apoptosis and KI 67 index correlate with preoperative chemotherapy efficacy and better predict the survival of gastric cancer patients with combined therapy.CANCER CHEMOTHERAPY AND PHARMACOLOGY,73(5),885-893.
MLA Wu, Aiwen,et al."Apoptosis and KI 67 index correlate with preoperative chemotherapy efficacy and better predict the survival of gastric cancer patients with combined therapy".CANCER CHEMOTHERAPY AND PHARMACOLOGY 73.5(2014):885-893.
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