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Promoter methylation of p16 associated with Helicobacter pylori infection in precancerous gastric lesions: A population-based study
Dong, Cai-Xuan1; Deng, Da-Jun2; Pan, Kai-Feng1; Zhang, Lian1; Zhang, Yang1; Zhou, Jing2; You, Wei-Cheng1
关键词stomach neoplasms precancerous conditions p16 gene methylation Helicobacter pylori
刊名INTERNATIONAL JOURNAL OF CANCER
2009-01-15
DOI10.1002/ijc.23891
124期:2页:434-439
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]CPG ISLAND METHYLATION ; ABERRANT DNA METHYLATION ; TUMOR-SUPPRESSOR GENE ; HUMAN CANCERS ; HOMOZYGOUS DELETIONS ; CHRONIC INFLAMMATION ; MTS1 GENE ; HIGH-RISK ; HYPERMETHYLATION ; ERADICATION
英文摘要

To investigate the relationship between p16 methylation and Helicobacter pylori infection in precancerous gastric lesions, a population-based study was conducted in Linqu County, a high-risk area of gastric cancer in China. Methylation status of p16 Was evaluated by methylation-specific polymerase chain reaction in 920 subjects with precancerous gastric lesions. H. pylon status was determined by (13)C-urea breath test and the density of H. pylon in biopsy specimens used for detecting methylation status was assessed by the modified Giemsa stain. The frequency of p16 methylation was significantly higher in subjects with H. pylon positive than those with H. pylori negative in each category or gastric lesion (p < 0.001, respectively). Compared with H. pylori negative, the odds ratios (ORs) p16 methylation were markedly elevated in subjects with H. pylori positive for superficial gastritis (OR, 9.45; 95% confidence interval [CI]: 2.94-30.41), chronic atrophic gastritis (OR, 15.92; 95%CI: 7.60-33.36), intestinal metaplasia (OR, 4.46; 95%CI: 2.44-8.13), indefinite dysplasia (OR, 3.67; 95% CI: 1.90-7.10), and dysplasia (OR, 2.48; 95%CI: 1.02-5.99). Moreover, the frequencies or p16 methylation increased steadily with the severity of H. pylori density in gastric mucosa. Compared with H. pylon negative, the OR of p16 methylation was 1.02-16.13 times higher in subjects with mild H. pylori infection, and 2.69-38.73 times higher in those with moderate/severe infection, respectively. Our findings indicate that p16 methylation was significantly associated with H. pylori infection in precancerous gastric lesions, suggesting that H. pylori infection could potently induce methylation of p16 CpG island. (C) 2008 Wiley-Liss. Inc.

语种英语
WOS记录号WOS:000262010600024
项目编号2006AA02A402 ; 2005CB522403 ; 434
资助机构National High Technology RD Program (863) ; National Basic Research Program of China ; Capital Program for Development of Health Sciences
引用统计
被引频次:44[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59618
专题北京大学临床肿瘤学院_流行病学研究室
北京大学临床肿瘤学院_病因学研究室
北京大学临床肿瘤学院_党院办公室
作者单位1.Peking Univ, Dept Canc Epidemiol, Sch Oncol, Beijing Canc Hosp & Inst, Beijing 100036, Peoples R China
2.Peking Univ, Dept Etiol, Sch Oncol, Beijing Canc Hosp & Inst, Beijing 100036, Peoples R China
推荐引用方式
GB/T 7714
Dong, Cai-Xuan,Deng, Da-Jun,Pan, Kai-Feng,et al. Promoter methylation of p16 associated with Helicobacter pylori infection in precancerous gastric lesions: A population-based study[J]. INTERNATIONAL JOURNAL OF CANCER,2009,124(2):434-439.
APA Dong, Cai-Xuan.,Deng, Da-Jun.,Pan, Kai-Feng.,Zhang, Lian.,Zhang, Yang.,...&You, Wei-Cheng.(2009).Promoter methylation of p16 associated with Helicobacter pylori infection in precancerous gastric lesions: A population-based study.INTERNATIONAL JOURNAL OF CANCER,124(2),434-439.
MLA Dong, Cai-Xuan,et al."Promoter methylation of p16 associated with Helicobacter pylori infection in precancerous gastric lesions: A population-based study".INTERNATIONAL JOURNAL OF CANCER 124.2(2009):434-439.
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