北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学临床肿瘤学院  > 流行病学研究室  > 期刊论文
学科主题: 临床医学
题名:
Promoter methylation of p16 associated with Helicobacter pylori infection in precancerous gastric lesions: A population-based study
作者: Dong, Cai-Xuan1; Deng, Da-Jun2; Pan, Kai-Feng1; Zhang, Lian1; Zhang, Yang1; Zhou, Jing2; You, Wei-Cheng1
关键词: stomach neoplasms ; precancerous conditions ; p16 gene ; methylation ; Helicobacter pylori
刊名: INTERNATIONAL JOURNAL OF CANCER
发表日期: 2009-01-15
DOI: 10.1002/ijc.23891
卷: 124, 期:2, 页:434-439
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: CPG ISLAND METHYLATION ; ABERRANT DNA METHYLATION ; TUMOR-SUPPRESSOR GENE ; HUMAN CANCERS ; HOMOZYGOUS DELETIONS ; CHRONIC INFLAMMATION ; MTS1 GENE ; HIGH-RISK ; HYPERMETHYLATION ; ERADICATION
英文摘要:

To investigate the relationship between p16 methylation and Helicobacter pylori infection in precancerous gastric lesions, a population-based study was conducted in Linqu County, a high-risk area of gastric cancer in China. Methylation status of p16 Was evaluated by methylation-specific polymerase chain reaction in 920 subjects with precancerous gastric lesions. H. pylon status was determined by (13)C-urea breath test and the density of H. pylon in biopsy specimens used for detecting methylation status was assessed by the modified Giemsa stain. The frequency of p16 methylation was significantly higher in subjects with H. pylon positive than those with H. pylori negative in each category or gastric lesion (p < 0.001, respectively). Compared with H. pylori negative, the odds ratios (ORs) p16 methylation were markedly elevated in subjects with H. pylori positive for superficial gastritis (OR, 9.45; 95% confidence interval [CI]: 2.94-30.41), chronic atrophic gastritis (OR, 15.92; 95%CI: 7.60-33.36), intestinal metaplasia (OR, 4.46; 95%CI: 2.44-8.13), indefinite dysplasia (OR, 3.67; 95% CI: 1.90-7.10), and dysplasia (OR, 2.48; 95%CI: 1.02-5.99). Moreover, the frequencies or p16 methylation increased steadily with the severity of H. pylori density in gastric mucosa. Compared with H. pylon negative, the OR of p16 methylation was 1.02-16.13 times higher in subjects with mild H. pylori infection, and 2.69-38.73 times higher in those with moderate/severe infection, respectively. Our findings indicate that p16 methylation was significantly associated with H. pylori infection in precancerous gastric lesions, suggesting that H. pylori infection could potently induce methylation of p16 CpG island. (C) 2008 Wiley-Liss. Inc.

语种: 英语
所属项目编号: 2006AA02A402 ; 2005CB522403 ; 434
项目资助者: National High Technology RD Program (863) ; National Basic Research Program of China ; Capital Program for Development of Health Sciences
WOS记录号: WOS:000262010600024
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59618
Appears in Collections:北京大学临床肿瘤学院_流行病学研究室_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Dept Canc Epidemiol, Sch Oncol, Beijing Canc Hosp & Inst, Beijing 100036, Peoples R China
2.Peking Univ, Dept Etiol, Sch Oncol, Beijing Canc Hosp & Inst, Beijing 100036, Peoples R China

Recommended Citation:
Dong, Cai-Xuan,Deng, Da-Jun,Pan, Kai-Feng,et al. Promoter methylation of p16 associated with Helicobacter pylori infection in precancerous gastric lesions: A population-based study[J]. INTERNATIONAL JOURNAL OF CANCER,2009,124(2):434-439.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Dong, Cai-Xuan]'s Articles
[Deng, Da-Jun]'s Articles
[Pan, Kai-Feng]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Dong, Cai-Xuan]‘s Articles
[Deng, Da-Jun]‘s Articles
[Pan, Kai-Feng]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace