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学科主题: 临床医学
题名:
Alleviation of hypoxic pulmonary vascular structural remodeling by L-arginine
作者: Qi, JG; Du, JB; Wang, L; Zhao, B; Tang, CS
关键词: L-arginine ; endothelin ; pulmonary artery ; hypoxia ; nitric oxide
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2001-09-01
卷: 114, 期:9, 页:933-936
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: SMOOTH-MUSCLE CELLS ; NITRIC-OXIDE ; INTRAPULMONARY ARTERIES ; HYPERTENSION ; RATS ; PROLIFERATION ; NEWBORN
英文摘要:

Objective To explore the effect of L-arginine on hypoxic pulmonary vascular structural remodeling and its possible mechanisms.

Methods Eighteen Wistar rats were randomly divided into three groups: the hypoxia group, the hypoxia with L-arginine group and the control group. Pulmonary artery mean pressure was evaluated with right cardiac catheterization. Pulmonary vascular structural changes were also observed. Plasma concentration of nitric oxide (NO) was measured via spectrophotometry, and endothelin-1 (ET-1) mRNA expression in pulmonary artery endothelial cells was detected using in situ hybridization.

Results The pulmonary artery mean pressure was significantly high in hypoxic rats than in normal controls (20.33 +/- 2.18 mm Hg vs 15.38 +/- 1.05 mm Hg, P < 0. 05). Microstructural and ultrastructural analysis revealed the development of hypoxic pulmonary vascular structural remodeling in the hypoxic rats. Meanwhile, the plasma NO concentration was markedly lower in the hypoxic rats than in controls ( P < 0. 05). The expression signals of ET-1 mRNA by pulmonary artery endothelial cells of hypoxic rats strengthened obviously. L-arginine ameliorated pulmonary hypertension (16.73 +/- 1.35 mm Hg vs 20.33 +/- 2.18 mm Hg, P < 0.05) as well as pulmonary vascular structural remodeling in the hypoxic rats in association with an increase in plasma NO concentration ( P < 0. 05) and inhibited ET-1 mRNA expression by the endothelial cells of pulmonary arteries.

Conclusion L-arginine might play an important role in the regulation of hypoxic pulmonary vascular structural remodeling and hypoxic pulmonary hypertension. The mechanism is probably related to promoting NO production and, as a result, inhibiting ET-1 mRNA expression by pulmonary artery endothelial cells in hypoxic rats.

语种: 英语
WOS记录号: WOS:000171143400010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59626
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: 1.Beijing Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
2.Beijing Univ, Hosp 1, Inst Cardiovasc Res, Beijing 100034, Peoples R China
3.Beijing Univ, Hlth Sci Ctr, Beijing 100083, Peoples R China
4.Beijing Ji Shui Tan Hosp, Dept Internal Med, Beijing 100034, Peoples R China

Recommended Citation:
Qi, JG,Du, JB,Wang, L,et al. Alleviation of hypoxic pulmonary vascular structural remodeling by L-arginine[J]. CHINESE MEDICAL JOURNAL,2001,114(9):933-936.
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