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Coordination of thrombolytic Pro-Ala-Lys peptides with Cu (II): Leading to nanoscale self-assembly, increase of thrombolytic activity and additional vasodilation
Ren, Xue1; Cui, Guohui2; Zhao, Ming2; Wang, Chao1; Peng, Shiqi1,2
刊名JOURNAL OF PHYSICAL CHEMISTRY B
2008-07-10
DOI10.1021/jp800645g
112期:27页:8174-8180
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Physical
研究领域[WOS]Chemistry
关键词[WOS]BLOOD-FLOW ; PENTAPEPTIDE ; FABRICATION ; COMPLEXES ; PROTEINS ; ANALOGS ; FIBRIN ; P6A
英文摘要

Vasodilation is one of the biologically important properties for thrombolytic agents because of it may help thrombolysis via dilating blood vessels. Aimed at discovering agents with the dual-action of vasodilative and thrombolytic activities, H-Pro-Ala-Lys (PAK, 3a) and five novel analogs H-Pro-Ala-AA (2b-f, AA = Val, Phe, Ser, Glu, and His) were coordinated with Cu(II) to form Cu(II)-Pro-Ala-AA [(3a-f)-Cu(II)]. The coordination chemistry was confirmed by the d-d transition occurred in their UV and circular dichroism (CD) spectra and the molecular ion in their electrospray ionization mass spectrometry (ESI-MS) spectra. The particle size tests of their solution and powders revealed that the coordination generally resulted in nanoscale self-assembly. Zeta potential and half-peak width tests indicated that the formed nanoparticles were sufficiently stable during the monitored 8 days. The bioassays implied that comparing to the PAK peptides themselves and CuCl(2) the coordination led to a 3000-fold increase of the in vitro thrombolytic activity, a 10-fold increase of the in vivo thrombolytic activity, and especially an additional vasodilation. Thus Cu(II)-peptide coordination indeed is a way for thrombolytic peptide design.

语种英语
WOS记录号WOS:000257335200029
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59627
专题北京大学药学院
作者单位1.Peking Univ, Coll Pharmaceut Sci, Beijing 100083, Peoples R China
2.Capital Med Univ, Coll Pharmaceut Sci, Beijing 100069, Peoples R China
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GB/T 7714
Ren, Xue,Cui, Guohui,Zhao, Ming,et al. Coordination of thrombolytic Pro-Ala-Lys peptides with Cu (II): Leading to nanoscale self-assembly, increase of thrombolytic activity and additional vasodilation[J]. JOURNAL OF PHYSICAL CHEMISTRY B,2008,112(27):8174-8180.
APA Ren, Xue,Cui, Guohui,Zhao, Ming,Wang, Chao,&Peng, Shiqi.(2008).Coordination of thrombolytic Pro-Ala-Lys peptides with Cu (II): Leading to nanoscale self-assembly, increase of thrombolytic activity and additional vasodilation.JOURNAL OF PHYSICAL CHEMISTRY B,112(27),8174-8180.
MLA Ren, Xue,et al."Coordination of thrombolytic Pro-Ala-Lys peptides with Cu (II): Leading to nanoscale self-assembly, increase of thrombolytic activity and additional vasodilation".JOURNAL OF PHYSICAL CHEMISTRY B 112.27(2008):8174-8180.
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