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学科主题: 药学
题名:
Hypolipidemic and anti-atherogenic effects of long-term Cholestin (Monascus purpureus-fermented rice, red yeast rice) in cholesterol fed rabbits
作者: Wei, W; Li, CL; Wang, YY; Su, HD; Zhu, HS; Kritchevsky, D
关键词: atherosclerosis ; Cholestin (Monascus purpureus rice ; red yeast rice) ; HMG-CoA reductase inhibitors ; hyperlipidemia ; red yeast rice
刊名: JOURNAL OF NUTRITIONAL BIOCHEMISTRY
发表日期: 2003-06-01
DOI: 10.1016/S0955-2863(03)00051-2
卷: 14, 期:6, 页:314-318
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Nutrition & Dietetics
研究领域[WOS]: Biochemistry & Molecular Biology ; Nutrition & Dietetics
关键词[WOS]: HMG-COA REDUCTASE ; HYPOCHOLESTEROLEMIC AGENT ; LDL-CHOLESTEROL ; MONACOLIN-K ; SIMVASTATIN ; INHIBITORS ; LOVASTATIN ; COENZYME ; MEDICINE ; FOOD
英文摘要:

Long-term effects of Cholestin (Monascus purpureus rice; red yeast rice) on serum lipids and severity of atherosclerosis were examined in rabbits fed for 200 days on a semi-purified diet containing 0.25% cholesterol. Serum total cholesterol was 25 and 40% lower, respectively, in rabbits fed 0.4 or 1.35 g/kg/day of Cholestin (Monascus purpureus rice; red yeast rice) compared to controls. This treatment also lowered serum LDL cholesterol. This 200-day treatment significantly reduced serum triglycerides and atherosclerotic index (ratio of non-HDL-cholesterol to HDL-cholesterol). Although similar reductions of total, LDL-cholesterol and triglycerides were observed, a parallel group of rabbits fed lovastatin (0.0024g/kg/day) failed to reduce the index significantly. Apolipoprotein A, was increased and apolipoprotein B was reduced in all treatment groups. Severity of atherosclerosis was reduced significantly in all treatment groups. The sudanophilic area of involvement was 80.6% in controls, and reduced significantly; to 30.1% on the low dose of Cholestin (Monascus purpureus rice; red yeast rice), and 17.2% on the high dose. Lovastatin reduced severity of lesions by 89% (sudanophilia) and 84% (visual). Visual grading of lesion severity showed reduction by 38% and 68%. (C) 2003 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000184432000003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59632
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA
2.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Biochem Pharmacol, Beijing 100083, Peoples R China
3.Pharmanex Pharmacol & Clin Ctr, Beijing 100088, Peoples R China
4.Pharmanex LLC, Provo, UT 84601 USA

Recommended Citation:
Wei, W,Li, CL,Wang, YY,et al. Hypolipidemic and anti-atherogenic effects of long-term Cholestin (Monascus purpureus-fermented rice, red yeast rice) in cholesterol fed rabbits[J]. JOURNAL OF NUTRITIONAL BIOCHEMISTRY,2003,14(6):314-318.
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