IR@PKUHSC  > 北京大学第三临床医学院  > 眼科
学科主题临床医学
Efficiency and safety of subconjunctival injection of anti-VEGF agent - bevacizumab - in treating dry eye
Jiang, Xiaodan; Lv, Huibin; Qiu, Weiqiang; Liu, Ziyuan; Li, Xuemin; Wang, Wei
关键词anti-VEGF bevacizumab dry eye ocular surface inflammation subconjunctival
刊名DRUG DESIGN DEVELOPMENT AND THERAPY
2015
DOI10.2147/DDDT.S85529
9页:3043-3050
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]DISEASE ; SURFACE ; FLUORESCEIN ; OSMOLARITY ; CYTOKINES ; CELLS ; TEARS
英文摘要

Purpose: Dry eye is a chronic inflammatory ocular surface disease with high prevalence. The current therapies for dry eye remain to be unspecific and notcomprehensive. This study aims to explore safety and efficacy of a novel treatment -subconjunctival injection of bevacizumab -in dry eye patients.

Methods: Sixty-four eyes of 32 dry eye patients received subconjunctival injection of 100 mu L 25 mg/mL bevacizumab. Dry eye symptoms, signs (corrected visual acuity, intraocular pressure, conjunctival vascularity, corneal staining, tear break-up time, Marx line score, and blood pressure), and conjunctival impression cytology were evaluated 3 days before and 1 week, 1 month, and 3 months after injection.

Results: Significant improvements were observed in dry eye symptoms, tear break-up time, and conjunctival vascularization area at all the visits after injection compared to the baseline (P<0.05). The density of the goblet cell increased significantly at 1 month and 3 months after injection (P<0.05). There was no visual and systemic threat observed in any patient.

Conclusion: Subconjunctival injection of 100 mu L 25 mg/mL bevacizumab is a safe and efficient treatment for ocular surface inflammation of dry eye disease.

语种英语
WOS记录号WOS:000356191800001
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59633
Collection北京大学第三临床医学院_眼科
作者单位Peking Univ, Hosp 3, Dept Ophthalmol, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Jiang, Xiaodan,Lv, Huibin,Qiu, Weiqiang,et al. Efficiency and safety of subconjunctival injection of anti-VEGF agent - bevacizumab - in treating dry eye[J]. DRUG DESIGN DEVELOPMENT AND THERAPY,2015,9:3043-3050.
APA Jiang, Xiaodan,Lv, Huibin,Qiu, Weiqiang,Liu, Ziyuan,Li, Xuemin,&Wang, Wei.(2015).Efficiency and safety of subconjunctival injection of anti-VEGF agent - bevacizumab - in treating dry eye.DRUG DESIGN DEVELOPMENT AND THERAPY,9,3043-3050.
MLA Jiang, Xiaodan,et al."Efficiency and safety of subconjunctival injection of anti-VEGF agent - bevacizumab - in treating dry eye".DRUG DESIGN DEVELOPMENT AND THERAPY 9(2015):3043-3050.
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