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学科主题: 临床医学
题名:
Local administration of icariin contributes to peripheral nerve regeneration and functional recovery
作者: Chen, Bo1; Niu, Su-ping2; Wang, Zhi-yong3; Wang, Zhen-wei2; Deng, Jiu-xu1; Zhang, Pei-xun1; Yin, Xiao-feng1; Han, Na1; Kou, Yu-hui1; Jiang, Bao-guo1
关键词: nerve regeneration ; peripheral nerve ; sciatic nerve ; traditional Chinese medicine ; icariin ; sleeve bridging suture ; nerve growth factor ; NSFC grants ; neural regeneration
刊名: NEURAL REGENERATION RESEARCH
发表日期: 2015
DOI: 10.4103/1673-5374.150711
卷: 10, 期:1, 页:84-89
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Neurosciences
研究领域[WOS]: Cell Biology ; Neurosciences & Neurology
关键词[WOS]: SMALL-GAP TUBULIZATION ; GROWTH-FACTOR ; NEUROTROPHIC FACTOR ; SUSTAINED-RELEASE ; MICROSPHERES ; REPAIR ; INJURY ; RATS
英文摘要:

Our previous study showed that systemic administration of the traditional Chinese medicine Epimedium extract promotes peripheral nerve regeneration. Here, we sought to explore the therapeutic effects of local administration of icariin, a major component of Epimedium extract, on peripheral nerve regeneration. A poly(lactic-co-glycolic acid) biological conduit sleeve was used to bridge a 5 mm right sciatic nerve defect in rats, and physiological saline, nerve growth factor, icariin suspension, or nerve growth factor-releasing microsphere suspension was injected into the defect. Twelve weeks later, sciatic nerve conduction velocity and the number of myelinated fibers were notably greater in the rats treated with icariin suspension or nerve growth factor-releasing microspheres than those that had received nerve growth factor or physiological saline. The effects of icariin suspension were similar to those of nerve growth factor-releasing microspheres. These data suggest that icariin acts as a nerve growth factor-releasing agent, and indicate that local application of icariin after spinal injury can promote peripheral nerve regeneration.

语种: 英语
所属项目编号: 2014CB542200 ; 31271284 ; 81171146 ; 31100860 ; 7142164 ; IRT1201
项目资助者: National Program on Key Basic Research Project of China (973 Program) ; National Natural Science Foundation of China ; Natural Science Foundation of Beijing of China ; Program for Innovative Research Team in University of Ministry of Education of China
WOS记录号: WOS:000350098100022
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59649
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Capital Med Univ, Beijing Shijitan Hosp, Beijing, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Beijing 100871, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Trauma & Orthoped, Beijing 100871, Peoples R China

Recommended Citation:
Chen, Bo,Niu, Su-ping,Wang, Zhi-yong,et al. Local administration of icariin contributes to peripheral nerve regeneration and functional recovery[J]. NEURAL REGENERATION RESEARCH,2015,10(1):84-89.
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