IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Local administration of icariin contributes to peripheral nerve regeneration and functional recovery
Chen, Bo1; Niu, Su-ping2; Wang, Zhi-yong3; Wang, Zhen-wei2; Deng, Jiu-xu1; Zhang, Pei-xun1; Yin, Xiao-feng1; Han, Na1; Kou, Yu-hui1; Jiang, Bao-guo1
关键词nerve regeneration peripheral nerve sciatic nerve traditional Chinese medicine icariin sleeve bridging suture nerve growth factor NSFC grants neural regeneration
刊名NEURAL REGENERATION RESEARCH
2015
DOI10.4103/1673-5374.150711
10期:1页:84-89
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Neurosciences
研究领域[WOS]Cell Biology ; Neurosciences & Neurology
关键词[WOS]SMALL-GAP TUBULIZATION ; GROWTH-FACTOR ; NEUROTROPHIC FACTOR ; SUSTAINED-RELEASE ; MICROSPHERES ; REPAIR ; INJURY ; RATS
英文摘要

Our previous study showed that systemic administration of the traditional Chinese medicine Epimedium extract promotes peripheral nerve regeneration. Here, we sought to explore the therapeutic effects of local administration of icariin, a major component of Epimedium extract, on peripheral nerve regeneration. A poly(lactic-co-glycolic acid) biological conduit sleeve was used to bridge a 5 mm right sciatic nerve defect in rats, and physiological saline, nerve growth factor, icariin suspension, or nerve growth factor-releasing microsphere suspension was injected into the defect. Twelve weeks later, sciatic nerve conduction velocity and the number of myelinated fibers were notably greater in the rats treated with icariin suspension or nerve growth factor-releasing microspheres than those that had received nerve growth factor or physiological saline. The effects of icariin suspension were similar to those of nerve growth factor-releasing microspheres. These data suggest that icariin acts as a nerve growth factor-releasing agent, and indicate that local application of icariin after spinal injury can promote peripheral nerve regeneration.

语种英语
WOS记录号WOS:000350098100022
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59649
专题北京大学第二临床医学院
北京大学基础医学院
作者单位1.Capital Med Univ, Beijing Shijitan Hosp, Beijing, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Beijing 100871, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Trauma & Orthoped, Beijing 100871, Peoples R China
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GB/T 7714
Chen, Bo,Niu, Su-ping,Wang, Zhi-yong,et al. Local administration of icariin contributes to peripheral nerve regeneration and functional recovery[J]. NEURAL REGENERATION RESEARCH,2015,10(1):84-89.
APA Chen, Bo.,Niu, Su-ping.,Wang, Zhi-yong.,Wang, Zhen-wei.,Deng, Jiu-xu.,...&Jiang, Bao-guo.(2015).Local administration of icariin contributes to peripheral nerve regeneration and functional recovery.NEURAL REGENERATION RESEARCH,10(1),84-89.
MLA Chen, Bo,et al."Local administration of icariin contributes to peripheral nerve regeneration and functional recovery".NEURAL REGENERATION RESEARCH 10.1(2015):84-89.
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