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学科主题: 临床医学
题名:
Pilot Postoperative Ileus Study of Escin in Cancer Patients After Colorectal Surgery
作者: Xie, Qiwei1; Zong, Xianglong2; Ge, Baoming3; Wang, Shan1; Ji, Jiafu2; Ye, Yingjiang1; Pan, Lili
刊名: WORLD JOURNAL OF SURGERY
发表日期: 2009-02-01
DOI: 10.1007/s00268-008-9816-1
卷: 33, 期:2, 页:348-354
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Surgery
研究领域[WOS]: Surgery
关键词[WOS]: PLACEBO-CONTROLLED TRIAL ; GASTROINTESTINAL TRANSIT ; POSSIBLE INVOLVEMENT ; MICE ; IB ; INHIBITIONS ; CISAPRIDE ; RECEPTORS ; ARTICLE ; IIB
英文摘要:

Background Postoperative ileus, a common complication in patients after abdominal surgery, brings no benefit to the recovery of postoperative patients, and treatment targeted at restoring gastrointestinal motility may shorten the hospital stay. Studies have shown that escin accelerates gastrointestinal transit in mice and improves gastrointestinal motility in patients after abdominal surgery. A pilot study of escin′s effect on the recovery of gastrointestinal motility was conducted in colorectal cancer patients in anticipation of a multiple-center randomized controlled trial.

Methods A total of 72 postoperative colorectal cancer patients were randomly assigned to four parallel groups on the basis of sealed envelopes-escin 5 mg group (E5 mg), escin 15 mg group (E15 mg), escin 25 mg group (E25 mg), and placebo group-with 18 patients in each group. Escin or placebo was diluted in 500 ml 5% dextrose injection, which was given once daily through the subclavian vein. The first injection took place 6 h after completion of the surgery. The treatment continued for 7 days or stopped at the time of the patient′s first bowel movement. Time to recovery of passage of gas (TRPG), time to recovery of gastrointestinal sounds (TRGS), and time to recovery of bowel movements (TRBM) were recorded to evaluate the efficacy of escin.

Results The TRPGs of the three escin treatment groups were 76.78 + 28.81 h (E5 mg), 72.06 + 14.65 h (E15 mg), and 65.50 + 26.70 h (E25 mg), respectively, with differences of 6.03 +/- 7.64 h (p = 0.436; E5 mg), 10.75 +/- 4.92 h (p = 0.036; E15 mg), and 17.31 +/- 7.20 h (p = 0.022; E25 mg) compared with the placebo group. The TRGSs of the three escin treatment groups were 45.28 +/- 26.15 h (E5 mg), 41.22 +/- 16.98 h (E15 mg), and 40.33 +/- 14.09 h (E25 mg), respectively, with differences of 4.33 +/- 7.12 h (p = 0.547; E5 mg), 8.39 +/- 5.36 h (p = 0.127; E15 mg), and 9.28 +/- 4.87 h (p = 0.065; E25 mg) compared with the placebo group. The TRBMs of the three escin treatment groups were 89.25 +/- 23.77 h (E5 mg), 84.83 +/- 27.91 h (E15 mg), and 84.44 +/- 19.74 h (E25 mg), respectively, with differences of 19.03 +/- 10.13 h (p = 0.069; E5 mg), 23.44 +/- 10.70 h (p = 0.035; E15 mg), and 23.83 +/- 9.63 h (p = 0.019; E25 mg) compared with the placebo group.

Conclusion The results of this pilot Postoperative Ileus Study of Escin (PISE) showed that escin can shorten the time to recovery of gastrointestinal motility in cancer patients after colorectal surgery.

语种: 英语
WOS记录号: WOS:000264997700030
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59650
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Chinese Clin Trial Coordinat Ctr, Beijing 100025, Peoples R China
2.Peking Univ, Dept Surg, Peoples Hosp, Beijing 100044, Peoples R China
3.Peking Univ, Dept Surg, Beijing Canc Hosp, Beijing 100036, Peoples R China

Recommended Citation:
Xie, Qiwei,Zong, Xianglong,Ge, Baoming,et al. Pilot Postoperative Ileus Study of Escin in Cancer Patients After Colorectal Surgery[J]. WORLD JOURNAL OF SURGERY,2009,33(2):348-354.
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