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学科主题: 临床医学
题名:
Effects of transcranial direct current stimulation (tDCS) on multiscale complexity of dual-task postural control in older adults
作者: Zhou, Diange1,2; Zhou, Junhong2; Chen, Hu3; Manor, Brad4,5,6; Lin, Jianhao1; Zhang, Jue2
关键词: Postural control ; Dual task ; tDCS ; Elderly ; Multiscale entropy
刊名: EXPERIMENTAL BRAIN RESEARCH
发表日期: 2015-08-01
DOI: 10.1007/s00221-015-4310-0
卷: 233, 期:8, 页:2401-2409
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: PREFRONTAL CORTEX ; ENTROPY ANALYSIS ; HEART-RATE ; PHYSIOLOGICAL COMPLEXITY ; APPROXIMATE ENTROPY ; BRAIN-STIMULATION ; WORKING-MEMORY ; DYNAMICS ; PERFORMANCE ; ATTENTION
英文摘要:

Transcranial direct current stimulation (tDCS) targeting the prefrontal cortex reduces the size and speed of standing postural sway in younger adults, particularly when performing a cognitive dual task. Here, we hypothesized that tDCS would alter the complex dynamics of postural sway as quantified by multiscale entropy (MSE). Twenty healthy older adults completed two study visits. Center-of-pressure (COP) fluctuations were recorded during single-task (i.e., quiet standing) and dual-task (i.e., standing while performing serial subtractions) conditions, both before and after a 20-min session of real or sham tDCS. MSE was used to estimate COP complexity within each condition. The percentage change in complexity from single- to dual-task conditions (i.e., dual-task cost) was also calculated. Before tDCS, COP complexity was lower (p = 0.04) in the dual-task condition as compared to the single-task condition. Neither real nor sham tDCS altered complexity in the single-task condition. As compared to sham tDCS, real tDCS increased complexity in the dual-task condition (p = 0.02) and induced a trend toward improved serial subtraction performance (p = 0.09). Moreover, those subjects with lower dual-task COP complexity at baseline exhibited greater percentage increases in complexity following real tDCS (R = -0.39, p = 0.05). Real tDCS also reduced the dual-task cost to complexity (p = 0.02), while sham stimulation had no effect. A single session of tDCS targeting the prefrontal cortex increased standing postural sway complexity with concurrent non-postural cognitive task. This form of noninvasive brain stimulation may be a safe strategy to acutely improve postural control by enhancing the system′s capacity to adapt to stressors.

语种: 英语
所属项目编号: 11372013 ; 1K01AG044543-01A1
项目资助者: National Natural Science Foundation of China ; National Institute on Aging
WOS记录号: WOS:000358322500016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59656
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Arthrit Clin & Res Ctr, Beijing 10044, Peoples R China
2.Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China
3.Peking Univ, Off Educ Adm, Beijing 100871, Peoples R China
4.Hebrew SeniorLife, Inst Aging Res, Roslindale, MA USA
5.Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA
6.Harvard Univ, Sch Med, Boston, MA USA

Recommended Citation:
Zhou, Diange,Zhou, Junhong,Chen, Hu,et al. Effects of transcranial direct current stimulation (tDCS) on multiscale complexity of dual-task postural control in older adults[J]. EXPERIMENTAL BRAIN RESEARCH,2015,233(8):2401-2409.
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