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Glycemic index and glycemic load are associated with some cardiovascular risk factors among the PREMIER study participants
Lin, Pao-Hwa1; Chen, Chuhe2; Young, Deborah R.3; Mitchell, Diane4; Elmer, Patricia2; Wang, Yanfang5; Batch, Bryan6; Champagne, Catherine7
关键词glycemic index glycemic load diet cardiovascular risk
刊名FOOD & NUTRITION RESEARCH
2012
DOI10.3402/fnr.v56i0.9464
56
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Food Science & Technology ; Nutrition & Dietetics
研究领域[WOS]Food Science & Technology ; Nutrition & Dietetics
关键词[WOS]CORONARY-HEART-DISEASE ; DENSITY-LIPOPROTEIN CHOLESTEROL ; RANDOMIZED CONTROLLED-TRIAL ; LIFE-STYLE MODIFICATION ; OBESE YOUNG-ADULTS ; DIETARY FIBER ; INSULIN SENSITIVITY ; BODY-COMPOSITION ; CLINICAL-TRIAL ; BLOOD-PRESSURE
英文摘要

Background: The clinical significance of glycemic index (GI) and glycemic load (GL) is inconclusive.

Objective: This study was conducted to examine the association of GI and GL with clinical cardiovascular disease (CVD) risk factors including body weight, blood pressure (BP), serum lipids, fasting glucose, insulin and homocysteine over time among the PREMIER participants.

Design: PREMIER was an 18-month randomized lifestyle intervention trial, conducted from 2000 to 2002, designed to help participants reduce BP by following the Dietary Approaches to Stop Hypertension (DASH) dietary pattern, losing weight, reducing sodium and increasing physical activity. GI and GL were estimated from 24 h diet recall data at baseline, 6 and 18 months after intervention. PROC MIXED model was used to examine the association of changes in GI or GL with changes in CVD risk factors.

Results: A total of 756 randomized participants, 62% females and 34% African Americans and who averaged 50.0 +/- 0.3 years old and 95.3 +/- 0.7 kg, were included in this report. Neither GI nor GL changes was associated with changes in any risk factors at 6 months. At 18 months, however, the GI change was significantly and positively associated with total cholesterol (TC) change only (p<0.05, beta = 23.80 +/- 12.11 mg/dL or 0.62 +/- 0.31 mmol/L) with a significant age interaction. The GL change was significantly associated with TC (p = 0.02, beta = 0.28 +/- 0.15 mg/dL or 0.01 +/- 0.00 mmol/L) positively and with low density lipoprotein cholesterol (LDL-C) changes negatively (p = 0.03, beta = -0.01 +/- 0.00 mg/dL or -0.00 +/- 0.00 mmol/L), and significant age interactions were observed for both.

Conclusion: GI and GL was associated with TC and LDL-C after controlling for energy, fat and fiber intake and other potential confounders and the associations were modified by age. Further investigation into this relationship is important because of its potential clinical impact.

语种英语
WOS记录号WOS:000317137700001
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59658
专题北京大学临床研究所
作者单位1.DUMC, Dept Med, Div Endocrinol, Durham, NC 27710 USA
2.DUMC, Dept Med, Div Nephrol, Durham, NC 27710 USA
3.Kaiser Permanente Ctr Hlth Res, Portland, OR USA
4.Univ Maryland, Sch Publ Hlth, Dept Epidemiol & Biostat, College Pk, MD 20742 USA
5.Penn State Univ, Diet Assessment Ctr, University Pk, PA 16802 USA
6.Peking Univ, Hlth Sci Ctr, Clin Res Inst, Beijing 100871, Peoples R China
7.Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA USA
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GB/T 7714
Lin, Pao-Hwa,Chen, Chuhe,Young, Deborah R.,et al. Glycemic index and glycemic load are associated with some cardiovascular risk factors among the PREMIER study participants[J]. FOOD &amp; NUTRITION RESEARCH,2012,56.
APA Lin, Pao-Hwa.,Chen, Chuhe.,Young, Deborah R..,Mitchell, Diane.,Elmer, Patricia.,...&Champagne, Catherine.(2012).Glycemic index and glycemic load are associated with some cardiovascular risk factors among the PREMIER study participants.FOOD & NUTRITION RESEARCH,56.
MLA Lin, Pao-Hwa,et al."Glycemic index and glycemic load are associated with some cardiovascular risk factors among the PREMIER study participants".FOOD & NUTRITION RESEARCH 56(2012).
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