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学科主题: 临床医学
题名:
Glycemic index and glycemic load are associated with some cardiovascular risk factors among the PREMIER study participants
作者: Lin, Pao-Hwa1; Chen, Chuhe2; Young, Deborah R.3; Mitchell, Diane4; Elmer, Patricia2; Wang, Yanfang5; Batch, Bryan6; Champagne, Catherine7
关键词: glycemic index ; glycemic load ; diet ; cardiovascular risk
刊名: FOOD & NUTRITION RESEARCH
发表日期: 2012
DOI: 10.3402/fnr.v56i0.9464
卷: 56
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Food Science & Technology ; Nutrition & Dietetics
研究领域[WOS]: Food Science & Technology ; Nutrition & Dietetics
关键词[WOS]: CORONARY-HEART-DISEASE ; DENSITY-LIPOPROTEIN CHOLESTEROL ; RANDOMIZED CONTROLLED-TRIAL ; LIFE-STYLE MODIFICATION ; OBESE YOUNG-ADULTS ; DIETARY FIBER ; INSULIN SENSITIVITY ; BODY-COMPOSITION ; CLINICAL-TRIAL ; BLOOD-PRESSURE
英文摘要:

Background: The clinical significance of glycemic index (GI) and glycemic load (GL) is inconclusive.

Objective: This study was conducted to examine the association of GI and GL with clinical cardiovascular disease (CVD) risk factors including body weight, blood pressure (BP), serum lipids, fasting glucose, insulin and homocysteine over time among the PREMIER participants.

Design: PREMIER was an 18-month randomized lifestyle intervention trial, conducted from 2000 to 2002, designed to help participants reduce BP by following the Dietary Approaches to Stop Hypertension (DASH) dietary pattern, losing weight, reducing sodium and increasing physical activity. GI and GL were estimated from 24 h diet recall data at baseline, 6 and 18 months after intervention. PROC MIXED model was used to examine the association of changes in GI or GL with changes in CVD risk factors.

Results: A total of 756 randomized participants, 62% females and 34% African Americans and who averaged 50.0 +/- 0.3 years old and 95.3 +/- 0.7 kg, were included in this report. Neither GI nor GL changes was associated with changes in any risk factors at 6 months. At 18 months, however, the GI change was significantly and positively associated with total cholesterol (TC) change only (p<0.05, beta = 23.80 +/- 12.11 mg/dL or 0.62 +/- 0.31 mmol/L) with a significant age interaction. The GL change was significantly associated with TC (p = 0.02, beta = 0.28 +/- 0.15 mg/dL or 0.01 +/- 0.00 mmol/L) positively and with low density lipoprotein cholesterol (LDL-C) changes negatively (p = 0.03, beta = -0.01 +/- 0.00 mg/dL or -0.00 +/- 0.00 mmol/L), and significant age interactions were observed for both.

Conclusion: GI and GL was associated with TC and LDL-C after controlling for energy, fat and fiber intake and other potential confounders and the associations were modified by age. Further investigation into this relationship is important because of its potential clinical impact.

语种: 英语
WOS记录号: WOS:000317137700001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59658
Appears in Collections:北京大学临床研究所_期刊论文

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作者单位: 1.DUMC, Dept Med, Div Endocrinol, Durham, NC 27710 USA
2.DUMC, Dept Med, Div Nephrol, Durham, NC 27710 USA
3.Kaiser Permanente Ctr Hlth Res, Portland, OR USA
4.Univ Maryland, Sch Publ Hlth, Dept Epidemiol & Biostat, College Pk, MD 20742 USA
5.Penn State Univ, Diet Assessment Ctr, University Pk, PA 16802 USA
6.Peking Univ, Hlth Sci Ctr, Clin Res Inst, Beijing 100871, Peoples R China
7.Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA USA

Recommended Citation:
Lin, Pao-Hwa,Chen, Chuhe,Young, Deborah R.,et al. Glycemic index and glycemic load are associated with some cardiovascular risk factors among the PREMIER study participants[J]. FOOD &amp; NUTRITION RESEARCH,2012,56.
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