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A pegylated liposomal platform: Pharmacokinetics, pharmacodynamics, and toxicity in mice using doxorubicin as a model drug
Lu, WL; Qi, XR; Zhang, Q; Li, RY; Wang, GL; Zhang, RJ; Wei, SL
关键词pegylated liposomal platform doxorubicin pharmacokinetics pharmacodynamics toxicity
刊名JOURNAL OF PHARMACOLOGICAL SCIENCES
2004-07-01
95期:3页:381-389
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]SOLID TUMORS ; CARCINOMA ; EFFICACY ; METABOLITES ; MURINE
英文摘要

Aims were to observe pharmacokinetics, pharmacodynamics, and toxicity for constructing a Sino-pegylated liposomal platform. Human hepatocarcinoma cells (Bel7402) and murine hepatocarcinoma cells (H-22) were used for the cytotoxicity assay and the in vivo solid xenograft tumor model in mice, respectively. Pharmacokinetic results in mice showed that the pegylated liposomal doxorubicin markedly prolonged the blood circulation of doxorubicin. Elimination half-time (T-1/2,T-gamma) of pegylated, regular liposomal doxorubicin and free doxorubicin were 46.09 +/- 14.44, 26.04 +/- 3.34, and 23.72 +/- 5.13 h, respectively. The area under the concentration-time curves (AUC(0-infinity)) (h(.)mug/g) of the pegylated and regular liposomal doxorubicin were 6.8- and 2.6-fold higher than that of free doxorubicin, respectively. Cytotoxicity and antitumor activity in vivo indicated that activity of the pegylated liposomal doxorubicin was higher than that of the regular or the free one, respectively. After two weeks of tail intravenous injection of the pegylated liposomal doxorubicin at a single dose of 10 mg/kg, no significant damage was observed in gastric, intestinal mucosa, and heart muscle, but pronounced damages were found in the control group after dosing free doxorubicin. The results demonstrate that the pegylated liposomes improve the efficacy of toxics and reduce the toxicity, therefore providing favorable evidence for building a pegylated liposomal platform.

语种英语
WOS记录号WOS:000222877100012
引用统计
被引频次:47[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59660
专题北京大学药学院_药剂学系
作者单位Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100083, Peoples R China
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GB/T 7714
Lu, WL,Qi, XR,Zhang, Q,et al. A pegylated liposomal platform: Pharmacokinetics, pharmacodynamics, and toxicity in mice using doxorubicin as a model drug[J]. JOURNAL OF PHARMACOLOGICAL SCIENCES,2004,95(3):381-389.
APA Lu, WL.,Qi, XR.,Zhang, Q.,Li, RY.,Wang, GL.,...&Wei, SL.(2004).A pegylated liposomal platform: Pharmacokinetics, pharmacodynamics, and toxicity in mice using doxorubicin as a model drug.JOURNAL OF PHARMACOLOGICAL SCIENCES,95(3),381-389.
MLA Lu, WL,et al."A pegylated liposomal platform: Pharmacokinetics, pharmacodynamics, and toxicity in mice using doxorubicin as a model drug".JOURNAL OF PHARMACOLOGICAL SCIENCES 95.3(2004):381-389.
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