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学科主题: 临床医学
题名:
Usefulness of complement activation products in Chinese patients with systemic lupus erythematosus
作者: Li, J.1,2; An, L.3,4; Zhang, Z.1,3,4
关键词: systemic lupus erythematosus ; complement ; C3d ; C4d ; lymphocyte ; biomarker
刊名: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
发表日期: 2014
卷: 32, 期:1, 页:48-53
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Rheumatology
研究领域[WOS]: Rheumatology
关键词[WOS]: DISEASE-ACTIVITY ; REVISED CRITERIA ; 4TH COMPONENT ; C4D ; MARKER ; CLASSIFICATION ; EXACERBATIONS ; BIOMARKERS ; CHIDO ; C3D
英文摘要:

Objective

To evaluate the roles of complement activation products C3d and C4d binding to lymphocytes in the diagnosis of systemic lupus erythematosus (SLE) in a cohort of Chinese patients.

Methods

96 patients with SLE, 44 patients with other autoimmune disease and 40 healthy control individuals were enrolled in this study. The levels of C3d and C4d binding to peripheral CD4(+) T and CD19+ B lymphocyts (designated as T-C3d, T-C4d, B-C3d, B-C4d) was assessed by flow cytometry. The diagnostic values of these biomarkers were determined by receiver-operator characteristic analysis.

Results

The levels of T-C3d, T-C4d, B-C3d, B-C4d were significantly higher in SLE patients than patients with other disease and healthy controls (p<0.01). As diagnostic tools, T-C4d and B-C4d were 61.1% sensitive 194.3% specific and 63.9% sensitive 194.3% specific in differentiating SLE patients from patients with other disease and healthy controls, respectively. T-C4d and B-C4d were significantly associated with SLE disease activity as measured by the SLE disease activity index (SLEDAI) (p<0.001), low serum C3 (p<0.001), low serum C4 (p=0.006), anti-dsDNA (IF) (p=0.001), and anti-dsDNA (ELISA) (p=0.001).

Conclusion

Complement activation products C3d and C4d binding to lymphocytes can reflect the disease activity of SLE and can be used as biomarkers for SLE.

语种: 英语
WOS记录号: WOS:000332682100008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59669
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Rheumatol & Clin Immunol Dept, Beijing 100034, Peoples R China
2.Gen Hosp Tisco, Renal Dept, Taiyuan, Shanxi, Peoples R China
3.Peking Univ, Hosp 1, Dept Rheumatol, Beijing 100034, Peoples R China
4.Peking Univ, Hosp 1, Dept Clin Immunol, Beijing 100034, Peoples R China

Recommended Citation:
Li, J.,An, L.,Zhang, Z.. Usefulness of complement activation products in Chinese patients with systemic lupus erythematosus[J]. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY,2014,32(1):48-53.
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