IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
Usefulness of complement activation products in Chinese patients with systemic lupus erythematosus
Li, J.1,2; An, L.3,4; Zhang, Z.1,3,4
关键词systemic lupus erythematosus complement C3d C4d lymphocyte biomarker
刊名CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
2014
32期:1页:48-53
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Rheumatology
研究领域[WOS]Rheumatology
关键词[WOS]DISEASE-ACTIVITY ; REVISED CRITERIA ; 4TH COMPONENT ; C4D ; MARKER ; CLASSIFICATION ; EXACERBATIONS ; BIOMARKERS ; CHIDO ; C3D
英文摘要

Objective

To evaluate the roles of complement activation products C3d and C4d binding to lymphocytes in the diagnosis of systemic lupus erythematosus (SLE) in a cohort of Chinese patients.

Methods

96 patients with SLE, 44 patients with other autoimmune disease and 40 healthy control individuals were enrolled in this study. The levels of C3d and C4d binding to peripheral CD4(+) T and CD19+ B lymphocyts (designated as T-C3d, T-C4d, B-C3d, B-C4d) was assessed by flow cytometry. The diagnostic values of these biomarkers were determined by receiver-operator characteristic analysis.

Results

The levels of T-C3d, T-C4d, B-C3d, B-C4d were significantly higher in SLE patients than patients with other disease and healthy controls (p<0.01). As diagnostic tools, T-C4d and B-C4d were 61.1% sensitive 194.3% specific and 63.9% sensitive 194.3% specific in differentiating SLE patients from patients with other disease and healthy controls, respectively. T-C4d and B-C4d were significantly associated with SLE disease activity as measured by the SLE disease activity index (SLEDAI) (p<0.001), low serum C3 (p<0.001), low serum C4 (p=0.006), anti-dsDNA (IF) (p=0.001), and anti-dsDNA (ELISA) (p=0.001).

Conclusion

Complement activation products C3d and C4d binding to lymphocytes can reflect the disease activity of SLE and can be used as biomarkers for SLE.

语种英语
WOS记录号WOS:000332682100008
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59669
专题北京大学第一临床医学院
作者单位1.Peking Univ, Hosp 1, Rheumatol & Clin Immunol Dept, Beijing 100034, Peoples R China
2.Gen Hosp Tisco, Renal Dept, Taiyuan, Shanxi, Peoples R China
3.Peking Univ, Hosp 1, Dept Rheumatol, Beijing 100034, Peoples R China
4.Peking Univ, Hosp 1, Dept Clin Immunol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Li, J.,An, L.,Zhang, Z.. Usefulness of complement activation products in Chinese patients with systemic lupus erythematosus[J]. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY,2014,32(1):48-53.
APA Li, J.,An, L.,&Zhang, Z..(2014).Usefulness of complement activation products in Chinese patients with systemic lupus erythematosus.CLINICAL AND EXPERIMENTAL RHEUMATOLOGY,32(1),48-53.
MLA Li, J.,et al."Usefulness of complement activation products in Chinese patients with systemic lupus erythematosus".CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 32.1(2014):48-53.
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