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学科主题: 药学
题名:
pH-sensitive polymeric nanoparticles to improve oral bioavailability of peptide/protein drugs and poorly water-soluble drugs
作者: Wang, Xue-Qing1; Zhang, Qiang1,2
关键词: pH-sensitive polymeric nanoparticles ; Oral bioavailability ; Absorption improvement ; Peptide and protein drugs ; Poorly water-soluble drugs
刊名: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
发表日期: 2012-10-01
DOI: 10.1016/j.ejpb.2012.07.014
卷: 82, 期:2, 页:219-229
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: CYCLOSPORINE-A ; CHITOSAN NANOPARTICLES ; PROTEIN DRUGS ; RESPONSIVE NANOPARTICLES ; INTESTINAL-ABSORPTION ; LOADED NANOPARTICLES ; RELEASE BEHAVIOR ; PERORAL DELIVERY ; INSULIN DELIVERY ; PHARMACOKINETICS
英文摘要:

pH-sensitive polymeric nanoparticles are promising for oral drug delivery, especially for peptide/protein drugs and poorly water-soluble medicines. This review describes current status of pH-sensitive polymeric nanoparticles for oral drug delivery and introduces the mechanisms of drug release from them as well as possible reasons for absorption improvement, with emphasis on our contribution to this field. pH-sensitive polymeric nanoparticles are prepared mainly with polyanions, polycations, their mixtures or cross-linked polymers. The mechanisms of drug release are the result of carriers′ dissolution, swelling or both of them at specific pH. The possible reasons for improvement of oral bioavailability include the following: improve drug stability, enhance mucoadhesion, prolong resident time in Cl tract: ameliorate intestinal permeability and increase saturation solubility and dissolution rate for poorly water-soluble drugs. As for the advantages of pH-sensitive nanoparticles over conventional nanoparticles, we conclude that (1) most carriers used are enteric-coating materials and their safety has been approved. (2) The rapid dissolution or swelling of carriers at specific pH results in quick drug release and high drug concentration gradient, which is helpful for absorption. (3) At the specific pH carriers dissolve or swell, and the bioadhesion of carriers to mucosa becomes high because nanoparticles turn from solid to gel, which can facilitate drug absorption. (C) 2012 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2009CB930300 ; 2009ZX09310-001
项目资助者: National Basic Research Program of China ; State Key Projects
WOS记录号: WOS:000312043300001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59672
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: 1.Peking Univ, Dept Pharmaceut, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Wang, Xue-Qing,Zhang, Qiang. pH-sensitive polymeric nanoparticles to improve oral bioavailability of peptide/protein drugs and poorly water-soluble drugs[J]. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS,2012,82(2):219-229.
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