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IR@PKUHSC  > 北京大学口腔医学院  > 口腔颌面外科  > 期刊论文
学科主题: 口腔医学
题名:
Characterization, corrosion behavior, cellular response and in vivo bone tissue compatibility of titanium-niobium alloy with low Young′s modulus
作者: Bai, Yanjie1,2,3; Deng, Yi1,4; Zheng, Yunfei1; Li, Yongliang1; Zhang, Ranran5; Lv, Yalin5; Zhao, Qiang2,3; Wei, Shicheng1,4
关键词: beta-Type titanium ; Titanium-niobium alloy ; Low Young&prime ; s modulus ; Biocompatibility ; Bone tissue compatibility
刊名: MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
发表日期: 2016-02-01
DOI: 10.1016/j.msec.2015.10.062
卷: 59, 页:565-576
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Materials Science, Biomaterials
研究领域[WOS]: Materials Science
关键词[WOS]: BIOMEDICAL APPLICATIONS ; MECHANICAL-PROPERTIES ; DENTAL APPLICATIONS ; MEDICAL IMPLANTS ; CASTING ALLOYS ; TI ; BIOCOMPATIBILITY ; SURFACE ; VITRO ; METAL
英文摘要:

beta-Type titanium alloys with a low elastic modulus are a potential strategy to enhance bone remodeling and to mitigate the concern over the risks of osteanabrosis and bone resorption caused by stress shielding, when used to substitute irreversibly impaired hard tissue. Hence, in this study, a Ti-45Nb alloy with low Young′s modulus and high strength was developed, and microstructure, mechanical properties, corrosion behaviors, cytocompatibility and in vivo osteo-compatibility of the alloy were systematically investigated for the first time. The results of mechanical tests showed that Young′s modulus of the Ti-Nb alloy was reduced to about 64.3 GPa (close to human cortical bone) accompanied with higher tensile strength and hardness compared with those of pure Ti. Importantly, the Ti-Nb alloy exhibited superior corrosion resistance to Ti in different solutions including SBF, MAS and FAAS (MAS containing NaF) media. In addition, the Ti-Nb alloy produced no deleterious effect to L929 and MG-63 cells, and cells performed excellent cell attachment onto Ti-Nb surface, indicating a good in vitro cytocompatibility. In vivo evaluations indicated that Ti-Nb had comparable bone tissue compatibility to Ti determined from micro-CT and histological evaluations. The Ti-Nb alloy with an elasticity close to human bone, thus, could be suitable for orthopedic/dental applications. (C) 2015 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 30973317
项目资助者: Natural Science Foundation of China ; Peking University&prime ; s 985 Grant
WOS记录号: WOS:000367107400068
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59679
Appears in Collections:北京大学口腔医学院_口腔颌面外科_期刊论文

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作者单位: 1.Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Lab Interdisciplinary Studies, Beijing 100081, Peoples R China
2.China Med Univ, Aviat Gen Hosp, Dept Stomatol, Beijing 100012, Peoples R China
3.Chinese Acad Sci, Beijing Inst Translat Med, Beijing 100012, Peoples R China
4.Peking Univ, Acad Adv Interdisciplinary Studies, Ctr Biomed Mat & Tissue Engn, Beijing 100871, Peoples R China
5.Capital Med Univ, Beijing Anzhen Hosp, Dept Stomatol, Beijing 100029, Peoples R China

Recommended Citation:
Bai, Yanjie,Deng, Yi,Zheng, Yunfei,et al. Characterization, corrosion behavior, cellular response and in vivo bone tissue compatibility of titanium-niobium alloy with low Young′s modulus[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2016,59:565-576.
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