学科主题临床医学
Transplanted Endothelial Progenitor Cells Ameliorate Carbon Tetrachloride-Induced Liver Cirrhosis in Rats
Liu, Feng; Liu, Zhi-Da; Wu, Nan; Cong, Xu; Fei, Ran; Chen, Hong-Song; Wei, Lai
刊名LIVER TRANSPLANTATION
2009-09-01
DOI10.1002/lt.21845
15期:9页:1092-1100
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology ; Surgery ; Transplantation
研究领域[WOS]Gastroenterology & Hepatology ; Surgery ; Transplantation
关键词[WOS]HEMATOPOIETIC STEM-CELLS ; HEPATOCYTE GROWTH-FACTOR ; HEPATIC-FIBROSIS ; GENE-THERAPY ; REGENERATION ; CONTRIBUTE ; SURVIVAL ; SCIENCE ; FUSION ; INJURY
英文摘要

Cirrhosis is the most common end stage of liver diseases, and there are no effective treatment methods. Here we evaluated the effect of endothelial progenitor cell (EPC) transplantation from rat bone marrow (BM) on the development of cirrhosis induced by carbon tetrachloride (CCl(4)). Ex vivo generated, characterized, and cultivated rat BM-derived EPCs were identified by their vasculogenic properties in vitro. EPCs from male rats were transplanted into female rats via the intraportal vein 12 weeks after they had been challenged with CCl(4), and the rats were killed 16 weeks later. The control rats received only a saline infusion. The fibrosis index and donor cell engraftment were assessed after EPC transplantation. After transplantation via the portal vein, PKH26 labeling, polymerase chain reaction, and in situ hybridization analysis revealed that the donor EPCs had adhered to the vasolateral surfaces of blood vessels and established in the liver. EPCs reduced the expression of a-smooth muscle actin, collagen III, and transforming growth factor beta (P < 0.05) as well as levels of aspartate aminotransferase, alanine aminotransferase, and total bilirubin in the serum (P < 0.05), but at the same time they increased the levels of albumin and Ki67. CCl(4) treatment increased the international prothrombin ratio (P < 0.05) and reduced albumin levels, whereas EPCs restored these parameters to normal levels. These results suggest that EPC transplantation could play a role in regulating hepatocyte regeneration and ameliorating established liver cirrhosis. Liver Transpl 15:1092-1100, 2009. (C) 2009 AASLD.

语种英语
WOS记录号WOS:000269596700014
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被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59680
专题北京大学第二临床医学院_北京大学肝病研究所
作者单位Peking Univ, Inst Hepatol, Peoples Hosp, Beijing 100044, Peoples R China
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GB/T 7714
Liu, Feng,Liu, Zhi-Da,Wu, Nan,et al. Transplanted Endothelial Progenitor Cells Ameliorate Carbon Tetrachloride-Induced Liver Cirrhosis in Rats[J]. LIVER TRANSPLANTATION,2009,15(9):1092-1100.
APA Liu, Feng.,Liu, Zhi-Da.,Wu, Nan.,Cong, Xu.,Fei, Ran.,...&Wei, Lai.(2009).Transplanted Endothelial Progenitor Cells Ameliorate Carbon Tetrachloride-Induced Liver Cirrhosis in Rats.LIVER TRANSPLANTATION,15(9),1092-1100.
MLA Liu, Feng,et al."Transplanted Endothelial Progenitor Cells Ameliorate Carbon Tetrachloride-Induced Liver Cirrhosis in Rats".LIVER TRANSPLANTATION 15.9(2009):1092-1100.
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