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学科主题口腔医学
Establishment of submandibular gland allotransplantation model in miniature swine
Ge, XY; Yu, GY; Cai, ZG; Mao, C
关键词submandibular gland transplantation miniature swine animal model
刊名CHINESE MEDICAL JOURNAL
2006-03-20
119期:6页:482-487
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]KERATOCONJUNCTIVITIS SICCA ; DRY EYE ; MICROVASCULAR TRANSPLANTATION ; XEROPHTHALMIA ; MANAGEMENT
英文摘要

Background Autologous transplantation of the submandibular gland (SMG) into the temporal fossa with microvascular anastomosis has been successfully applied in severe xerophthalmia patients as a permanent tear substitute. However, severe xerophthalmia can be accompanied by salivary gland dysfunction, making such autotransplantation unsuitable. Therefore, SMG allotransplantation might be a solution. The aim of this study was to assess the technical feasibility of submandibular gland allotransplantation.

Methods Twelve miniature swine were randomized to serve as donors or recipients. One SMG was transplanted between a donor and a recipient. The donor SMG was revascularized by microvascular anastomosis of its vascular pedicle to the recipient lingual artery and external jugular vein. The secretory duct was implanted into the vestibule of the mouth through a subcutaneous tunnel. No immunosuppressive agent was administered. The results were assessed by visual inspection of the secretion, and histopathological examination of the transplanted SMG.

Results Technically, all surgical procedures were successful. Clear secretion flowed out of the duct as soon as blood supply of the transplanted submandibular gland was reestablished. The secretion of the gland lasted for 5 days. As expected, an acute rejection reaction occurred after surgery because no immunosuppressive agents were used. Secretion from the transplanted SMG ceased within 5 days.

Conclusions A model of SMG allotransplantation can be established in miniature swine. The technique of submandibular gland allotransplantation is feasible.

语种英语
WOS记录号WOS:000236337800008
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59682
专题北京大学口腔医学院
作者单位Peking Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
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GB/T 7714
Ge, XY,Yu, GY,Cai, ZG,et al. Establishment of submandibular gland allotransplantation model in miniature swine[J]. CHINESE MEDICAL JOURNAL,2006,119(6):482-487.
APA Ge, XY,Yu, GY,Cai, ZG,&Mao, C.(2006).Establishment of submandibular gland allotransplantation model in miniature swine.CHINESE MEDICAL JOURNAL,119(6),482-487.
MLA Ge, XY,et al."Establishment of submandibular gland allotransplantation model in miniature swine".CHINESE MEDICAL JOURNAL 119.6(2006):482-487.
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