北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 免疫学系  > 期刊论文
学科主题: 基础医学
题名:
Detection of circulating cancer cells in lung cancer patients with a panel of marker genes
作者: Liu, Lei1; Liao, Guo-qing2; He, Pei3; Zhu, Hong3; Liu, Peng-hui2; Qu, Yi-mei2; Song, Xiao-ming4; Xu, Qing-wen1; Gao, Qian1,3; Zhang, Yu1; Chen, Wei-feng1; Yin, Yan-hui1
关键词: circulating cancer cell ; diagnosis ; BJ-TSA-9 ; KRT-19 ; lung cancer ; marker ; nested-PCR ; pre-proGRP ; prognosis
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2008-08-08
DOI: 10.1016/j.bbrc.2008.05.101
卷: 372, 期:4, 页:756-760
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: GASTRIN-RELEASING-PEPTIDE ; POLYMERASE-CHAIN-REACTION ; PERIPHERAL-BLOOD ; SENSITIVE DETECTION ; TUMOR-CELLS ; CARCINOMA ; SURVIVAL
英文摘要:

The current study was undertaken to examine the circulating cancer cells of lung cancer patients using a panel of markers and to evaluate the clinical significance of such tests. Peripheral blood mononuclear cells (PBMCs) from 134 lung cancer patients, 106 benign pulmonary disease, and 80 healthy individuals were isolated and assessed by nested reverse transcription-PCR assay for the expression of three different tumor markers, including tumor specific antigen 9 (TSA-9), Keratin 19 (KRT-19), and Pre-progastrin. releasing peptide (Pre-proGRP). Receiver operating characteristic curve (ROC) analysis showed that the combination of these markers was highly sensitive and specific in differentiating cancer patients from healthy and benign pulmonary disease controls. Of the 134 lung cancer patient blood samples, 84.3% expressed at least one tumor marker. A significant correlation was observed between the number of positive markers and disease stage and progression. Positivity of more than one marker predicted a poor response to therapy and short survival time in non-small cell lung cancer patients. (c) 2008 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000257419500045
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59692
Appears in Collections:基础医学院_免疫学系_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
1-s2.0-S0006291X08010322-main.pdf(482KB)期刊论文出版稿限制开放 联系获取全文

作者单位: 1.Peking Univ, Hosp 3, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100083, Peoples R China
3.Peoples Liberat Army Gen Hosp, Affiliated Hosp 2, Dept Oncol, Beijing 100091, Peoples R China
4.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100083, Peoples R China

Recommended Citation:
Liu, Lei,Liao, Guo-qing,He, Pei,et al. Detection of circulating cancer cells in lung cancer patients with a panel of marker genes[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2008,372(4):756-760.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Liu, Lei]'s Articles
[Liao, Guo-qing]'s Articles
[He, Pei]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Liu, Lei]‘s Articles
[Liao, Guo-qing]‘s Articles
[He, Pei]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace