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学科主题基础医学
Detection of circulating cancer cells in lung cancer patients with a panel of marker genes
Liu, Lei1; Liao, Guo-qing2; He, Pei3; Zhu, Hong3; Liu, Peng-hui2; Qu, Yi-mei2; Song, Xiao-ming4; Xu, Qing-wen1; Gao, Qian1,3; Zhang, Yu1; Chen, Wei-feng1; Yin, Yan-hui1
关键词circulating cancer cell diagnosis BJ-TSA-9 KRT-19 lung cancer marker nested-PCR pre-proGRP prognosis
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2008-08-08
DOI10.1016/j.bbrc.2008.05.101
372期:4页:756-760
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]GASTRIN-RELEASING-PEPTIDE ; POLYMERASE-CHAIN-REACTION ; PERIPHERAL-BLOOD ; SENSITIVE DETECTION ; TUMOR-CELLS ; CARCINOMA ; SURVIVAL
英文摘要

The current study was undertaken to examine the circulating cancer cells of lung cancer patients using a panel of markers and to evaluate the clinical significance of such tests. Peripheral blood mononuclear cells (PBMCs) from 134 lung cancer patients, 106 benign pulmonary disease, and 80 healthy individuals were isolated and assessed by nested reverse transcription-PCR assay for the expression of three different tumor markers, including tumor specific antigen 9 (TSA-9), Keratin 19 (KRT-19), and Pre-progastrin. releasing peptide (Pre-proGRP). Receiver operating characteristic curve (ROC) analysis showed that the combination of these markers was highly sensitive and specific in differentiating cancer patients from healthy and benign pulmonary disease controls. Of the 134 lung cancer patient blood samples, 84.3% expressed at least one tumor marker. A significant correlation was observed between the number of positive markers and disease stage and progression. Positivity of more than one marker predicted a poor response to therapy and short survival time in non-small cell lung cancer patients. (c) 2008 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000257419500045
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被引频次:36[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
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条目标识符http://ir.bjmu.edu.cn/handle/400002259/59692
专题北京大学基础医学院_免疫学系
北京大学基础医学院
北京大学公共卫生学院_劳动卫生与环境卫生学系
作者单位1.Peking Univ, Hosp 3, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100083, Peoples R China
3.Peoples Liberat Army Gen Hosp, Affiliated Hosp 2, Dept Oncol, Beijing 100091, Peoples R China
4.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100083, Peoples R China
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GB/T 7714
Liu, Lei,Liao, Guo-qing,He, Pei,et al. Detection of circulating cancer cells in lung cancer patients with a panel of marker genes[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2008,372(4):756-760.
APA Liu, Lei.,Liao, Guo-qing.,He, Pei.,Zhu, Hong.,Liu, Peng-hui.,...&Yin, Yan-hui.(2008).Detection of circulating cancer cells in lung cancer patients with a panel of marker genes.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,372(4),756-760.
MLA Liu, Lei,et al."Detection of circulating cancer cells in lung cancer patients with a panel of marker genes".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 372.4(2008):756-760.
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