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The hMLH1-93G > A Polymorphism and Risk of Ovarian Cancer in the Chinese Population
Niu, Leilei1; Li, Shumin2; Liang, Huamao1; Li, Hua1,2
刊名PLOS ONE
2015-08-14
DOI10.1371/journal.pone.0135822
10期:8
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]DNA MISMATCH REPAIR ; SINGLE-NUCLEOTIDE POLYMORPHISM ; UNSTABLE COLORECTAL-CANCER ; LUNG-CANCER ; NASOPHARYNGEAL CARCINOMA ; PROMOTER POLYMORPHISM ; PROSTATE-CANCER ; HMLH1 GENE ; MLH1 ; SUSCEPTIBILITY
英文摘要

Background

As a mismatch repair (MMR) gene, hMLH1 plays an important role in the maintenance of chromosomal integrity. Several studies have investigated the associations of hMLH1 -93G>A (rs1800734) and Ile219Val (rs1799977) in diverse tumor types with discordant results, but their roles in ovarian cancer in the Chinese population remains to be elucidated.

Methods

In a case-control analysis, we assessed the association between these two polymorphisms and ovarian cancer risk in 421 ovarian cancer patients and 689 control subjects in the Chinese population using logistic regression.

Results

We found that the variant hMLH1 genotypes (-93AA and AG) are associated with risk of ovarian cancer (adjusted odds ratio [OR] = 2.02, 95% confidence interval [CI] = 1.42-2.89) compared with the -93GG genotype. The A allele increases the risk of ovarian cancer in a dose-dependent manner (P<10(-4)). Functional test showed that -93A allele increased hMLH1 promoter transcriptional activity and the luciferase activity. However, no significant difference was found in the genotype frequencies at the Ile219Val site between the cases and controls.

Conclusions

These findings indicate that the -93G>A polymorphism in hMLH1 may affect ovarian cancer susceptibility in the Chinese population.

语种英语
WOS记录号WOS:000359493600121
项目编号81202040 ; 7142167 ; 2009B03
资助机构National Natural Scientific Foundation of China ; Beijing Municipal Natural Science Foundation ; Beijing Nova Program
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59708
专题北京大学第三临床医学院
北京大学第三临床医学院_妇产科
作者单位1.Peking Univ, Dept Obstet & Gynecol, Hosp 3, Beijing 100871, Peoples R China
2.Chinese Acad Med Sci, Dept Gynecol Oncol, Canc Hosp, Beijing 100730, Peoples R China
推荐引用方式
GB/T 7714
Niu, Leilei,Li, Shumin,Liang, Huamao,et al. The hMLH1-93G > A Polymorphism and Risk of Ovarian Cancer in the Chinese Population[J]. PLOS ONE,2015,10(8).
APA Niu, Leilei,Li, Shumin,Liang, Huamao,&Li, Hua.(2015).The hMLH1-93G > A Polymorphism and Risk of Ovarian Cancer in the Chinese Population.PLOS ONE,10(8).
MLA Niu, Leilei,et al."The hMLH1-93G > A Polymorphism and Risk of Ovarian Cancer in the Chinese Population".PLOS ONE 10.8(2015).
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