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学科主题: 临床医学
题名:
The hMLH1-93G > A Polymorphism and Risk of Ovarian Cancer in the Chinese Population
作者: Niu, Leilei1; Li, Shumin2; Liang, Huamao1; Li, Hua1,2
刊名: PLOS ONE
发表日期: 2015-08-14
DOI: 10.1371/journal.pone.0135822
卷: 10, 期:8
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: DNA MISMATCH REPAIR ; SINGLE-NUCLEOTIDE POLYMORPHISM ; UNSTABLE COLORECTAL-CANCER ; LUNG-CANCER ; NASOPHARYNGEAL CARCINOMA ; PROMOTER POLYMORPHISM ; PROSTATE-CANCER ; HMLH1 GENE ; MLH1 ; SUSCEPTIBILITY
英文摘要:

Background

As a mismatch repair (MMR) gene, hMLH1 plays an important role in the maintenance of chromosomal integrity. Several studies have investigated the associations of hMLH1 -93G>A (rs1800734) and Ile219Val (rs1799977) in diverse tumor types with discordant results, but their roles in ovarian cancer in the Chinese population remains to be elucidated.

Methods

In a case-control analysis, we assessed the association between these two polymorphisms and ovarian cancer risk in 421 ovarian cancer patients and 689 control subjects in the Chinese population using logistic regression.

Results

We found that the variant hMLH1 genotypes (-93AA and AG) are associated with risk of ovarian cancer (adjusted odds ratio [OR] = 2.02, 95% confidence interval [CI] = 1.42-2.89) compared with the -93GG genotype. The A allele increases the risk of ovarian cancer in a dose-dependent manner (P<10(-4)). Functional test showed that -93A allele increased hMLH1 promoter transcriptional activity and the luciferase activity. However, no significant difference was found in the genotype frequencies at the Ile219Val site between the cases and controls.

Conclusions

These findings indicate that the -93G>A polymorphism in hMLH1 may affect ovarian cancer susceptibility in the Chinese population.

语种: 英语
所属项目编号: 81202040 ; 7142167 ; 2009B03
项目资助者: National Natural Scientific Foundation of China ; Beijing Municipal Natural Science Foundation ; Beijing Nova Program
WOS记录号: WOS:000359493600121
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59708
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Peking Univ, Dept Obstet & Gynecol, Hosp 3, Beijing 100871, Peoples R China
2.Chinese Acad Med Sci, Dept Gynecol Oncol, Canc Hosp, Beijing 100730, Peoples R China

Recommended Citation:
Niu, Leilei,Li, Shumin,Liang, Huamao,et al. The hMLH1-93G &gt; A Polymorphism and Risk of Ovarian Cancer in the Chinese Population[J]. PLOS ONE,2015,10(8).
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