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学科主题: 药学
题名:
Echinacoside prevents the striatal extracellular levels of monoamine neurotransmitters from diminution in 6-hydroxydopamine lesion rats
作者: Chen, Hong; Jing, Fu Chun; Li, Chang Ling; Tu, Peng Fei; Zheng, Qiu Sheng; Wang, Zheng Hua
关键词: echinacoside ; dopamine ; 3,4-dihydroxyphenylethanoid acid ; homovanillic acid ; 6-hydroxydopamine ; Parkinson&prime ; s disease ; brain microdialysis ; rats
刊名: JOURNAL OF ETHNOPHARMACOLOGY
发表日期: 2007-12-03
DOI: 10.1016/j.jep.2007.07.035
卷: 114, 期:3, 页:285-289
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
关键词[WOS]: ALPHA-INDUCED APOPTOSIS ; 1-METHYL-4-PHENYLPYRIDINIUM ION ; NEURONAL CELLS ; PHENYLETHANOID GLYCOSIDES ; INHIBITS APOPTOSIS ; CISTANCHES-SALSA ; TUBULOSIDE-B ; ACTEOSIDE ; RESCUES ; INJURY
英文摘要:

We investigated the effects of echinacoside, a phenylethanoid glycoside isolated and purified from the stems of Cistanche salsa, a Chinese herbal medicine, on the striatal extracellular levels of dopamine (DA), 3,4-dihydroxyphenyl acetic acid (DOPAC) and homovartillic acid (HVA) in 6-hydroxydopamine (6-OHDA) lesion rats. Seven days after 6-OHDA was injected into the right striatum of rats, the striatal extracellular levels of DA, DOPAC and HVA fell significantly (P < 0.01 vs. vehicle), as demonstrated by the method of cerebral microdialysis and high performance liquid chromatography with electrochemical detection. However, simultaneous treatment with echinacoside (7.0, 3.5 mg/kg) attenuated the diminution of them (P < 0.01 vs. model). The results implied that echinacoside could protect the striatal dopaminergic neurons from injury induced by 6-OHDA and may be useful in the prevention and treatment of Parkinson′s disease (PD). (c) 2007 Published by Elsevier Ireland Ltd.

语种: 英语
WOS记录号: WOS:000251404500003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59713
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Shihezi Univ, Coll Pharm, Dept Pharmacol, Shihezi 832002, Peoples R China
2.Shihezi Univ, Minist Educ, Key Lab Xinjiang Phytomed Resources, Shihezi 832002, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, Dept Mol Pharmacol, Beijing 100083, Peoples R China
4.Peking Univ, Modern Res Ctr Tradition Chinese Med, Beijing 100083, Peoples R China

Recommended Citation:
Chen, Hong,Jing, Fu Chun,Li, Chang Ling,et al. Echinacoside prevents the striatal extracellular levels of monoamine neurotransmitters from diminution in 6-hydroxydopamine lesion rats[J]. JOURNAL OF ETHNOPHARMACOLOGY,2007,114(3):285-289.
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