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S100A8/A9 Induces Apoptosis and Inhibits Metastasis of CasKi Human Cervical Cancer Cells
Qin, Fengjin1; Song, Yao2,3; Li, Zijian2,3; Zhao, Ling1; Zhang, Youyi2,3; Geng, Li1
关键词Apoptosis Cervical cancer Metastasis MMP-2 S100 proteins
刊名PATHOLOGY & ONCOLOGY RESEARCH
2010-09-01
DOI10.1007/s12253-009-9225-2
16期:3页:353-360
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Pathology
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Oncology ; Pathology
关键词[WOS]TUMOR DIFFERENTIATION ; S100 PROTEINS ; EXPRESSION ; ADENOCARCINOMA ; CARCINOMA ; GENE
英文摘要

S100 proteins, a family of Ca(2+)-binding proteins, have been linked to several human diseases in recent years. Deregulated expression of S100 proteins, including S100A9 and its partner S100A8, was reported to be associated with neoplastic disorders. In our previous study using serial analysis of gene expression, we identified decreased expressions of S100A9 and S100A8 in human cervical squamous cell carcinoma. To investigate the functions of S100A8 and S100A9 in cervical cancer, we purified recombinant S100A8 and S100A9 proteins and treated CaSki human cervical cancer cells with these proteins. We found that S100A8/A9 induced apoptosis and inhibited migration of CaSki cells; S100A8/A9 also reduced the expression of matrix metalloproteinase (MMP)-2 in CaSki cells. In summary, this study suggests that S100A8 and S100A9 have inhibitory effects on the proliferation of CaSki carcinoma cells by inducing cell apoptosis and on the invasiveness of CaSki cells.

语种英语
所属项目编号30571939 ; 10772007
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000282230600008
引用统计
被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59715
专题北京大学第三临床医学院
作者单位1.Peking Univ, Dept Obstet & Gynaecol, Hosp 3, Beijing 100191, Peoples R China
2.Peking Univ, Inst Vasc Med, Hosp 3, Beijing 100191, Peoples R China
3.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
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Qin, Fengjin,Song, Yao,Li, Zijian,et al. S100A8/A9 Induces Apoptosis and Inhibits Metastasis of CasKi Human Cervical Cancer Cells[J]. PATHOLOGY & ONCOLOGY RESEARCH,2010,16(3):353-360.
APA Qin, Fengjin,Song, Yao,Li, Zijian,Zhao, Ling,Zhang, Youyi,&Geng, Li.(2010).S100A8/A9 Induces Apoptosis and Inhibits Metastasis of CasKi Human Cervical Cancer Cells.PATHOLOGY & ONCOLOGY RESEARCH,16(3),353-360.
MLA Qin, Fengjin,et al."S100A8/A9 Induces Apoptosis and Inhibits Metastasis of CasKi Human Cervical Cancer Cells".PATHOLOGY & ONCOLOGY RESEARCH 16.3(2010):353-360.
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