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学科主题: 临床医学
题名:
S100A8/A9 Induces Apoptosis and Inhibits Metastasis of CasKi Human Cervical Cancer Cells
作者: Qin, Fengjin1; Song, Yao2,3; Li, Zijian2,3; Zhao, Ling1; Zhang, Youyi2,3; Geng, Li1
关键词: Apoptosis ; Cervical cancer ; Metastasis ; MMP-2 ; S100 proteins
刊名: PATHOLOGY & ONCOLOGY RESEARCH
发表日期: 2010-09-01
DOI: 10.1007/s12253-009-9225-2
卷: 16, 期:3, 页:353-360
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Pathology
研究领域[WOS]: Oncology ; Pathology
关键词[WOS]: TUMOR DIFFERENTIATION ; S100 PROTEINS ; EXPRESSION ; ADENOCARCINOMA ; CARCINOMA ; GENE
英文摘要:

S100 proteins, a family of Ca(2+)-binding proteins, have been linked to several human diseases in recent years. Deregulated expression of S100 proteins, including S100A9 and its partner S100A8, was reported to be associated with neoplastic disorders. In our previous study using serial analysis of gene expression, we identified decreased expressions of S100A9 and S100A8 in human cervical squamous cell carcinoma. To investigate the functions of S100A8 and S100A9 in cervical cancer, we purified recombinant S100A8 and S100A9 proteins and treated CaSki human cervical cancer cells with these proteins. We found that S100A8/A9 induced apoptosis and inhibited migration of CaSki cells; S100A8/A9 also reduced the expression of matrix metalloproteinase (MMP)-2 in CaSki cells. In summary, this study suggests that S100A8 and S100A9 have inhibitory effects on the proliferation of CaSki carcinoma cells by inducing cell apoptosis and on the invasiveness of CaSki cells.

语种: 英语
所属项目编号: 30571939 ; 10772007
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000282230600008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59715
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Peking Univ, Dept Obstet & Gynaecol, Hosp 3, Beijing 100191, Peoples R China
2.Peking Univ, Inst Vasc Med, Hosp 3, Beijing 100191, Peoples R China
3.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China

Recommended Citation:
Qin, Fengjin,Song, Yao,Li, Zijian,et al. S100A8/A9 Induces Apoptosis and Inhibits Metastasis of CasKi Human Cervical Cancer Cells[J]. PATHOLOGY & ONCOLOGY RESEARCH,2010,16(3):353-360.
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